Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.

Ajnakina, Olesya; Rodriguez, Victoria; Quattrone, Diego; di Forti, Marta; Vassos, Evangelos; Arango, Celso; Berardi, Domenico; Bernardo, Miguel; Bobes, Julio; de Haan, Lieuwe; Del-Ben, Cristina Marta; Gayer-Anderson, Charlotte; Jongsma, Hannah E; Lasalvia, Antonio; Tosato, Sarah; Llorca, Pierre-Michel; Menezes, Paulo Rossi; Rutten, Bart P; Santos, Jose Luis; Sanjuan, Julio; Selten, Jean-Paul; Szoke, Andrei; Tarricone, Ilaria; D'Andrea, Giuseppe; Richards, Alexander; Tortelli, Andrea; Velthorst, Eva; Jones, Peter B; Arrojo Romero, Manuel; La Cascia, Caterina; Kirkbride, James B; van Os, Jim; O'Donovan, Mick; Murray, Robin M; EU-GEI WP2 Group

Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.

Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analy...

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Autores:	Ajnakina, Olesya, Rodriguez, Victoria, Quattrone, Diego, di Forti, Marta, Vassos, Evangelos, Arango, Celso, Berardi, Domenico, Bernardo, Miguel, Bobes, Julio, de Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Rutten, Bart P, Santos, Jose Luis, Sanjuan, Julio, Selten, Jean-Paul, Szoke, Andrei, Tarricone, Ilaria, D'Andrea, Giuseppe, Richards, Alexander, Tortelli, Andrea, Velthorst, Eva, Jones, Peter B, Arrojo Romero, Manuel, La Cascia, Caterina, Kirkbride, James B, van Os, Jim, O'Donovan, Mick, Murray, Robin M, EU-GEI WP2 Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	INCLIVA
Repositorio:	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:	oai:incliva.fundanetsuite.com:p15716
Acceso en línea:	https://incliva.portalinvestigacion.com/publicaciones/15716
Access Level:	acceso abierto
Palabra clave:	duration of untreated psychosis genome-wide association studies polygenic scores psychosis schizophrenia

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spelling	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.Ajnakina, OlesyaRodriguez, VictoriaQuattrone, Diegodi Forti, MartaVassos, EvangelosArango, CelsoBerardi, DomenicoBernardo, MiguelBobes, Juliode Haan, LieuweDel-Ben, Cristina MartaGayer-Anderson, CharlotteJongsma, Hannah ELasalvia, AntonioTosato, SarahLlorca, Pierre-MichelMenezes, Paulo RossiRutten, Bart PSantos, Jose LuisSanjuan, JulioSelten, Jean-PaulSzoke, AndreiTarricone, IlariaD'Andrea, GiuseppeRichards, AlexanderTortelli, AndreaVelthorst, EvaJones, Peter BArrojo Romero, ManuelLa Cascia, CaterinaKirkbride, James Bvan Os, JimO'Donovan, MickMurray, Robin MEU-GEI WP2 Groupduration of untreated psychosisgenome-wide association studiespolygenic scorespsychosisschizophreniaDuration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analyses of a large multi-center phenotypically well-defined sample encompassing individuals with a diagnosis of FEP recruited from 6 countries spanning 17 research sites, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. Genetic propensity was measured using polygenic scores for schizophrenia (SZ-PGS), bipolar disorder (BD-PGS), major depressive disorder (MDD-PGS), and intelligence (IQ-PGS), which were calculated based on the results from the most recent genome-wide association meta-analyses. Following imputation for missing data and log transformation of DUP to handle skewedness, the association between DUP and polygenic scores (PGS), adjusting for important confounders, was investigated with multivariable linear regression models. The sample comprised 619 individuals with a diagnosis of FEP disorders with a median age at first contact of 29.0 years (interquartile range [IQR] = 22.0-38.0). The median length of DUP in the sample was 10.1 weeks (IQR = 3.8-30.8). One SD increases in SZ-PGS, BD-PGS, MDD-PGS or IQ-PGS were not significantly associated with the length of DUP. Our results suggest that genetic variation does not contribute to the DUP in patients with a diagnosis of FEP disorders.OXFORD UNIV PRESS2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15716SCHIZOPHRENIA BULLETINISSN: 05867614ISSNe: 17451701reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p157162026-06-07T16:35:31Z
dc.title.none.fl_str_mv	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.
title	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.
spellingShingle	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study. Ajnakina, Olesya duration of untreated psychosis genome-wide association studies polygenic scores psychosis schizophrenia
title_short	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.
title_full	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.
title_fullStr	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.
title_full_unstemmed	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.
title_sort	Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.
dc.creator.none.fl_str_mv	Ajnakina, Olesya Rodriguez, Victoria Quattrone, Diego di Forti, Marta Vassos, Evangelos Arango, Celso Berardi, Domenico Bernardo, Miguel Bobes, Julio de Haan, Lieuwe Del-Ben, Cristina Marta Gayer-Anderson, Charlotte Jongsma, Hannah E Lasalvia, Antonio Tosato, Sarah Llorca, Pierre-Michel Menezes, Paulo Rossi Rutten, Bart P Santos, Jose Luis Sanjuan, Julio Selten, Jean-Paul Szoke, Andrei Tarricone, Ilaria D'Andrea, Giuseppe Richards, Alexander Tortelli, Andrea Velthorst, Eva Jones, Peter B Arrojo Romero, Manuel La Cascia, Caterina Kirkbride, James B van Os, Jim O'Donovan, Mick Murray, Robin M EU-GEI WP2 Group
author	Ajnakina, Olesya
author_facet	Ajnakina, Olesya Rodriguez, Victoria Quattrone, Diego di Forti, Marta Vassos, Evangelos Arango, Celso Berardi, Domenico Bernardo, Miguel Bobes, Julio de Haan, Lieuwe Del-Ben, Cristina Marta Gayer-Anderson, Charlotte Jongsma, Hannah E Lasalvia, Antonio Tosato, Sarah Llorca, Pierre-Michel Menezes, Paulo Rossi Rutten, Bart P Santos, Jose Luis Sanjuan, Julio Selten, Jean-Paul Szoke, Andrei Tarricone, Ilaria D'Andrea, Giuseppe Richards, Alexander Tortelli, Andrea Velthorst, Eva Jones, Peter B Arrojo Romero, Manuel La Cascia, Caterina Kirkbride, James B van Os, Jim O'Donovan, Mick Murray, Robin M EU-GEI WP2 Group
author_role	author
author2	Rodriguez, Victoria Quattrone, Diego di Forti, Marta Vassos, Evangelos Arango, Celso Berardi, Domenico Bernardo, Miguel Bobes, Julio de Haan, Lieuwe Del-Ben, Cristina Marta Gayer-Anderson, Charlotte Jongsma, Hannah E Lasalvia, Antonio Tosato, Sarah Llorca, Pierre-Michel Menezes, Paulo Rossi Rutten, Bart P Santos, Jose Luis Sanjuan, Julio Selten, Jean-Paul Szoke, Andrei Tarricone, Ilaria D'Andrea, Giuseppe Richards, Alexander Tortelli, Andrea Velthorst, Eva Jones, Peter B Arrojo Romero, Manuel La Cascia, Caterina Kirkbride, James B van Os, Jim O'Donovan, Mick Murray, Robin M EU-GEI WP2 Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	duration of untreated psychosis genome-wide association studies polygenic scores psychosis schizophrenia
topic	duration of untreated psychosis genome-wide association studies polygenic scores psychosis schizophrenia
description	Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analyses of a large multi-center phenotypically well-defined sample encompassing individuals with a diagnosis of FEP recruited from 6 countries spanning 17 research sites, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. Genetic propensity was measured using polygenic scores for schizophrenia (SZ-PGS), bipolar disorder (BD-PGS), major depressive disorder (MDD-PGS), and intelligence (IQ-PGS), which were calculated based on the results from the most recent genome-wide association meta-analyses. Following imputation for missing data and log transformation of DUP to handle skewedness, the association between DUP and polygenic scores (PGS), adjusting for important confounders, was investigated with multivariable linear regression models. The sample comprised 619 individuals with a diagnosis of FEP disorders with a median age at first contact of 29.0 years (interquartile range [IQR] = 22.0-38.0). The median length of DUP in the sample was 10.1 weeks (IQR = 3.8-30.8). One SD increases in SZ-PGS, BD-PGS, MDD-PGS or IQ-PGS were not significantly associated with the length of DUP. Our results suggest that genetic variation does not contribute to the DUP in patients with a diagnosis of FEP disorders.
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://incliva.portalinvestigacion.com/publicaciones/15716
url	https://incliva.portalinvestigacion.com/publicaciones/15716
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	OXFORD UNIV PRESS
publisher.none.fl_str_mv	OXFORD UNIV PRESS
dc.source.none.fl_str_mv	SCHIZOPHRENIA BULLETIN ISSN: 05867614 ISSNe: 17451701 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA
instname_str	INCLIVA
reponame_str	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.

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