The language profile of formal thought disorder

Formal thought disorder (FTD) is clinically manifested as disorganized speech, but there have been only few investigations of its linguistic properties. We examined how disturbance of thought may relate to the referential function of language as expressed in the use of noun phrases (NPs) and the com...

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Autores: Hinzen, Wolfram, Çokal, Derya, Sevilla, Gabriel, Jones, William Stephen, Zimmerer, Vitor C., Deamer, Felicity, Douglas, Maggie, Spencer, Helen, Turkington, Douglas, Ferrier, I. Nicol, Varley, Rosemary, Watson, Stuart
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/35585
Acceso en línea:http://hdl.handle.net/10230/35585
http://dx.doi.org/10.1038/s41537-018-0061-9
Access Level:acceso abierto
Palabra clave:Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
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spelling The language profile of formal thought disorderHinzen, WolframÇokal, DeryaSevilla, GabrielJones, William StephenZimmerer, Vitor C.Deamer, FelicityDouglas, MaggieSpencer, HelenTurkington, DouglasFerrier, I. NicolVarley, RosemaryWatson, StuartSchizophreniaFormal thought disorderLanguage and thoughtReferenceNarrativeFormal thought disorder (FTD) is clinically manifested as disorganized speech, but there have been only few investigations of its linguistic properties. We examined how disturbance of thought may relate to the referential function of language as expressed in the use of noun phrases (NPs) and the complexity of sentence structures. We used a comic strip description task to elicit language samples from 30 participants with schizophrenia (SZ), 15 with moderate or severe FTD (SZ + FTD), and 15 minimal or no FTD (SZ −FTD), as well as 15 first-degree relatives of people with SZ (FDRs) and 15 neurotypical controls (NC). We predicted that anomalies in the normal referential use of NPs, sub-divided into definite and indefinite NPs, would identify FTD; and also that FTD would also be linked to reduced linguistic complexity as specifically measured by the number of embedded clauses and of grammatical dependents. Participants with SZ + FTD produced more referential anomalies than NC and produced the fewest definite NPs, while FDRs produced the most and thus also differed from NC. When referential anomalies were classed according to the NP type in which they occurred, the SZ + FTD group produced more anomalies in definite NPs than NC. Syntactic errors did not distinguish groups, but the SZ + FTD group exhibited significantly less syntactic complexity than non-SZ groups. Exploratory regression analyses suggested that production of definite NPs distinguished the two SZ groups. These results demonstrate that FTD can be identified in specific grammatical patterns which provide new targets for detection, intervention, and neurobiological studies.This research was supported by the Northumberland, Tyne and Wear NHS Mental Health Foundation Trust, including Research Capability Funding; and the Arts and Humanities Research Council (grant number AH/L004070/1 to W.H.), and the Ministerio de Economía y Competitividad, Spanish Government (grant FFI2016-77647-C2-1-P to W.H.). We would also like to thank Olivia Bailey, Laura Pearson, Jonathan Kat, Charlotte Richardson, and Sophie Clews for their transcription help. In addition, we would like to acknowledge Sarah Page and Kelsey Stoddart for their assistance in building the database.Nature Publishing Group201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35585http://dx.doi.org/10.1038/s41537-018-0061-9reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNPJ Schizoph. 2018; 4. DOI: 10.1038/s41537-018-0061-9info:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-1-P© Nature Publishing Group. https://www.nature.com/articles/s41537-018-0061-9. Creative Commons Attribution License 4.0http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/355852026-06-12T07:21:37Z
dc.title.none.fl_str_mv The language profile of formal thought disorder
title The language profile of formal thought disorder
spellingShingle The language profile of formal thought disorder
Hinzen, Wolfram
Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
title_short The language profile of formal thought disorder
title_full The language profile of formal thought disorder
title_fullStr The language profile of formal thought disorder
title_full_unstemmed The language profile of formal thought disorder
title_sort The language profile of formal thought disorder
dc.creator.none.fl_str_mv Hinzen, Wolfram
Çokal, Derya
Sevilla, Gabriel
Jones, William Stephen
Zimmerer, Vitor C.
Deamer, Felicity
Douglas, Maggie
Spencer, Helen
Turkington, Douglas
Ferrier, I. Nicol
Varley, Rosemary
Watson, Stuart
author Hinzen, Wolfram
author_facet Hinzen, Wolfram
Çokal, Derya
Sevilla, Gabriel
Jones, William Stephen
Zimmerer, Vitor C.
Deamer, Felicity
Douglas, Maggie
Spencer, Helen
Turkington, Douglas
Ferrier, I. Nicol
Varley, Rosemary
Watson, Stuart
author_role author
author2 Çokal, Derya
Sevilla, Gabriel
Jones, William Stephen
Zimmerer, Vitor C.
Deamer, Felicity
Douglas, Maggie
Spencer, Helen
Turkington, Douglas
Ferrier, I. Nicol
Varley, Rosemary
Watson, Stuart
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
topic Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
description Formal thought disorder (FTD) is clinically manifested as disorganized speech, but there have been only few investigations of its linguistic properties. We examined how disturbance of thought may relate to the referential function of language as expressed in the use of noun phrases (NPs) and the complexity of sentence structures. We used a comic strip description task to elicit language samples from 30 participants with schizophrenia (SZ), 15 with moderate or severe FTD (SZ + FTD), and 15 minimal or no FTD (SZ −FTD), as well as 15 first-degree relatives of people with SZ (FDRs) and 15 neurotypical controls (NC). We predicted that anomalies in the normal referential use of NPs, sub-divided into definite and indefinite NPs, would identify FTD; and also that FTD would also be linked to reduced linguistic complexity as specifically measured by the number of embedded clauses and of grammatical dependents. Participants with SZ + FTD produced more referential anomalies than NC and produced the fewest definite NPs, while FDRs produced the most and thus also differed from NC. When referential anomalies were classed according to the NP type in which they occurred, the SZ + FTD group produced more anomalies in definite NPs than NC. Syntactic errors did not distinguish groups, but the SZ + FTD group exhibited significantly less syntactic complexity than non-SZ groups. Exploratory regression analyses suggested that production of definite NPs distinguished the two SZ groups. These results demonstrate that FTD can be identified in specific grammatical patterns which provide new targets for detection, intervention, and neurobiological studies.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35585
http://dx.doi.org/10.1038/s41537-018-0061-9
url http://hdl.handle.net/10230/35585
http://dx.doi.org/10.1038/s41537-018-0061-9
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv NPJ Schizoph. 2018; 4. DOI: 10.1038/s41537-018-0061-9
info:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-1-P
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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