Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration

Traumatic injuries to the peripheral (PNS) and central nervous systems (CNS) trigger distinct regenerative responses, with the PNS displaying limited regenerative capacity and the CNS remaining largely refractory. Recent research highlights the role of epigenetic modifications, particularly histone...

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Autores: Palomés Borrajo, Georgina|||0000-0002-8217-2054, Navarro, X. (Xavier)|||0000-0001-9849-902X, Penas Pérez, Clara|||0000-0003-0554-3832
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:318777
Acceso en línea:https://ddd.uab.cat/record/318777
https://dx.doi.org/urn:doi:10.3390/ijms26136277
Access Level:acceso abierto
Palabra clave:Epigenetics
Regeneration
Histone acetylation
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spelling Histone Acetylation in Central and Peripheral Nervous System Injuries and RegenerationEpigenetic Dynamics and Therapeutic PerspectivesPalomés Borrajo, Georgina|||0000-0002-8217-2054Navarro, X. (Xavier)|||0000-0001-9849-902XPenas Pérez, Clara|||0000-0003-0554-3832EpigeneticsRegenerationHistone acetylationTraumatic injuries to the peripheral (PNS) and central nervous systems (CNS) trigger distinct regenerative responses, with the PNS displaying limited regenerative capacity and the CNS remaining largely refractory. Recent research highlights the role of epigenetic modifications, particularly histone acetylation, in modulating the gene expression programs that drive axonal regeneration. This review synthesizes current findings on post-translational histone modifications, focusing on histone acetyltransferases (HATs), histone deacetylases (HDACs), and epigenetic readers, in addition to their impact on neuronal and non-neuronal cells following injury. While HATs like p300/CBP and PCAF promote the expression of regeneration-associated genes, HDAC inhibition has been shown to facilitate neurite outgrowth, neuroprotection, and functional recovery in both PNS and CNS models. However, HDAC3, HDAC5, and HDAC6 demonstrate context- and cell-type-specific roles in both promoting and limiting regenerative processes. The review also highlights cell-specific findings that have been scarcely covered in the previous literature. Thus, the immunomodulatory roles of epigenetic regulators in microglia and macrophages, their involvement in remyelination via Schwann cells and oligodendrocytes, and their impact on astrocyte function are within the scope of this review. Closely considering cell-context specificity is critical, as some targets can exert opposite effects depending on the cell type involved. This represents a major challenge for current pharmacological therapies, which often lack precision. This complexity underscores the need to develop strategies that allow for cell-specific delivery or target regulators with converging beneficial effects across cell types. Such approaches may enhance regenerative outcomes after CNS or PNS injury. 22025-01-0120252025-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/318777https://dx.doi.org/urn:doi:10.3390/ijms26136277reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2022-140655OB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CPP2022-009550open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3187772026-06-06T12:50:31Z
dc.title.none.fl_str_mv Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
Epigenetic Dynamics and Therapeutic Perspectives
title Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
spellingShingle Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
Palomés Borrajo, Georgina|||0000-0002-8217-2054
Epigenetics
Regeneration
Histone acetylation
title_short Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
title_full Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
title_fullStr Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
title_full_unstemmed Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
title_sort Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration
dc.creator.none.fl_str_mv Palomés Borrajo, Georgina|||0000-0002-8217-2054
Navarro, X. (Xavier)|||0000-0001-9849-902X
Penas Pérez, Clara|||0000-0003-0554-3832
author Palomés Borrajo, Georgina|||0000-0002-8217-2054
author_facet Palomés Borrajo, Georgina|||0000-0002-8217-2054
Navarro, X. (Xavier)|||0000-0001-9849-902X
Penas Pérez, Clara|||0000-0003-0554-3832
author_role author
author2 Navarro, X. (Xavier)|||0000-0001-9849-902X
Penas Pérez, Clara|||0000-0003-0554-3832
author2_role author
author
dc.subject.none.fl_str_mv Epigenetics
Regeneration
Histone acetylation
topic Epigenetics
Regeneration
Histone acetylation
description Traumatic injuries to the peripheral (PNS) and central nervous systems (CNS) trigger distinct regenerative responses, with the PNS displaying limited regenerative capacity and the CNS remaining largely refractory. Recent research highlights the role of epigenetic modifications, particularly histone acetylation, in modulating the gene expression programs that drive axonal regeneration. This review synthesizes current findings on post-translational histone modifications, focusing on histone acetyltransferases (HATs), histone deacetylases (HDACs), and epigenetic readers, in addition to their impact on neuronal and non-neuronal cells following injury. While HATs like p300/CBP and PCAF promote the expression of regeneration-associated genes, HDAC inhibition has been shown to facilitate neurite outgrowth, neuroprotection, and functional recovery in both PNS and CNS models. However, HDAC3, HDAC5, and HDAC6 demonstrate context- and cell-type-specific roles in both promoting and limiting regenerative processes. The review also highlights cell-specific findings that have been scarcely covered in the previous literature. Thus, the immunomodulatory roles of epigenetic regulators in microglia and macrophages, their involvement in remyelination via Schwann cells and oligodendrocytes, and their impact on astrocyte function are within the scope of this review. Closely considering cell-context specificity is critical, as some targets can exert opposite effects depending on the cell type involved. This represents a major challenge for current pharmacological therapies, which often lack precision. This complexity underscores the need to develop strategies that allow for cell-specific delivery or target regulators with converging beneficial effects across cell types. Such approaches may enhance regenerative outcomes after CNS or PNS injury.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/318777
https://dx.doi.org/urn:doi:10.3390/ijms26136277
url https://ddd.uab.cat/record/318777
https://dx.doi.org/urn:doi:10.3390/ijms26136277
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2022-140655OB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CPP2022-009550
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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