Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.

Purpose: To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods: Our study included 131 patients with wetAMD [age-related eye dis...

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Autores: Fernandez Robredo, Patricia, Recalde Maestre, Sergio, Hernandez, Maria, Zarranz Ventura, Javier, Molins Monteys, Blanca, Casaroli Marano, Ricardo Pedro, Adán Civera, Alfredo, Saenz de Viteri, Manuel, García Layana, Alfredo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/146859
Acceso en línea:https://hdl.handle.net/2445/146859
Access Level:acceso abierto
Palabra clave:Diferències entre sexes
Malalties de la retina
Degeneració (Patologia)
Sex differences
Retinal diseases
Degeneration (Pathology)
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spelling Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.Fernandez Robredo, PatriciaRecalde Maestre, SergioHernandez, MariaZarranz Ventura, JavierMolins Monteys, BlancaCasaroli Marano, Ricardo PedroAdán Civera, AlfredoSaenz de Viteri, ManuelGarcía Layana, AlfredoDiferències entre sexesMalalties de la retinaDegeneració (Patologia)Sex differencesRetinal diseasesDegeneration (Pathology)Purpose: To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods: Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) category 4] and 153 control participants (AREDS category 1) from two Spanish retinal units. CRP levels were determined on blood samples by high-sensitivity ELISA assay. According to their CRP level, subjects were categorized into three well-established CRP categories: low (< 1.00 mg/L, L-CRP), moderate (1-2.99 mg/L, M-CRP), and high (> 3.00 mg/L, H-CRP). Genomic DNA was extracted from oral swabs using QIAcube (Qiagen, Hilden, Germany) and the A69S; rs10490924 of ARMS2 gene was genotyped by allelic discrimination with validated TaqMan assays (Applied Biosystems, Foster City, CA, USA). Univariate and multivariate logistic regression adjusted for age was used to analyze the genomic frequencies and to calculate odds ratio (OR) using SNPStats software. Results: Considering CRP risk categories, H-CRP group showed a significant [OR 4.0 (1.9-8.3)] association with wetAMD compared to L-CRP group. The risk genotypes of A69S (TT) SNPs showed an association with wetAMD risk [OR 14.0 (4.8-40.8)]. Interestingly, the gender stratification of the CRP categories showed a significant increase in CRP levels in wetAMD women compared with control women [OR 6.9 (2.2-22.3)] and with wetAMD men [OR 4.6 (1.3-16.9)]. In addition, the subgroup analysis of CRP within A69S genotype and gender showed a link in women between the A69S and CRP levels in the AMD group compared to controls [OR 4.2 (1.4-12.6)]. Conclusion: Our study shows, for the first time, that a different genetic association related with gender could contribute to AMD risk. As a consequence, the risk of female gender in the different CRP levels and A69S SNP frequencies could be taken into consideration to the established risk relationship of high levels of CRP and its association with risk A69S genotype.Frontiers Media2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/146859Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.01862Frontiers in Immunology, 2018, vol. 9https://doi.org/10.3389/fimmu.2018.01862cc-by (c) Fernandez Robredo, Patricia et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1468592026-05-29T05:05:01Z
dc.title.none.fl_str_mv Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
title Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
spellingShingle Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
Fernandez Robredo, Patricia
Diferències entre sexes
Malalties de la retina
Degeneració (Patologia)
Sex differences
Retinal diseases
Degeneration (Pathology)
title_short Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
title_full Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
title_fullStr Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
title_full_unstemmed Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
title_sort Novel association of high c-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women.
dc.creator.none.fl_str_mv Fernandez Robredo, Patricia
Recalde Maestre, Sergio
Hernandez, Maria
Zarranz Ventura, Javier
Molins Monteys, Blanca
Casaroli Marano, Ricardo Pedro
Adán Civera, Alfredo
Saenz de Viteri, Manuel
García Layana, Alfredo
author Fernandez Robredo, Patricia
author_facet Fernandez Robredo, Patricia
Recalde Maestre, Sergio
Hernandez, Maria
Zarranz Ventura, Javier
Molins Monteys, Blanca
Casaroli Marano, Ricardo Pedro
Adán Civera, Alfredo
Saenz de Viteri, Manuel
García Layana, Alfredo
author_role author
author2 Recalde Maestre, Sergio
Hernandez, Maria
Zarranz Ventura, Javier
Molins Monteys, Blanca
Casaroli Marano, Ricardo Pedro
Adán Civera, Alfredo
Saenz de Viteri, Manuel
García Layana, Alfredo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diferències entre sexes
Malalties de la retina
Degeneració (Patologia)
Sex differences
Retinal diseases
Degeneration (Pathology)
topic Diferències entre sexes
Malalties de la retina
Degeneració (Patologia)
Sex differences
Retinal diseases
Degeneration (Pathology)
description Purpose: To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods: Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) category 4] and 153 control participants (AREDS category 1) from two Spanish retinal units. CRP levels were determined on blood samples by high-sensitivity ELISA assay. According to their CRP level, subjects were categorized into three well-established CRP categories: low (< 1.00 mg/L, L-CRP), moderate (1-2.99 mg/L, M-CRP), and high (> 3.00 mg/L, H-CRP). Genomic DNA was extracted from oral swabs using QIAcube (Qiagen, Hilden, Germany) and the A69S; rs10490924 of ARMS2 gene was genotyped by allelic discrimination with validated TaqMan assays (Applied Biosystems, Foster City, CA, USA). Univariate and multivariate logistic regression adjusted for age was used to analyze the genomic frequencies and to calculate odds ratio (OR) using SNPStats software. Results: Considering CRP risk categories, H-CRP group showed a significant [OR 4.0 (1.9-8.3)] association with wetAMD compared to L-CRP group. The risk genotypes of A69S (TT) SNPs showed an association with wetAMD risk [OR 14.0 (4.8-40.8)]. Interestingly, the gender stratification of the CRP categories showed a significant increase in CRP levels in wetAMD women compared with control women [OR 6.9 (2.2-22.3)] and with wetAMD men [OR 4.6 (1.3-16.9)]. In addition, the subgroup analysis of CRP within A69S genotype and gender showed a link in women between the A69S and CRP levels in the AMD group compared to controls [OR 4.2 (1.4-12.6)]. Conclusion: Our study shows, for the first time, that a different genetic association related with gender could contribute to AMD risk. As a consequence, the risk of female gender in the different CRP levels and A69S SNP frequencies could be taken into consideration to the established risk relationship of high levels of CRP and its association with risk A69S genotype.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/146859
url https://hdl.handle.net/2445/146859
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.01862
Frontiers in Immunology, 2018, vol. 9
https://doi.org/10.3389/fimmu.2018.01862
dc.rights.none.fl_str_mv cc-by (c) Fernandez Robredo, Patricia et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Fernandez Robredo, Patricia et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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