Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test

Among the Italian autochthonous beef cattle breeds, Marchigiana is particularly important in terms of census and production. In this breed, a SNP inactivating the myostatin gene leads to muscular hypertrophy in the individuals homozygous for the mutated allele while heterozygous individuals have an...

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Autores: Colombi, Daniele|||0000-0001-5167-0459, Perini, Francesco, Sbarra, Fiorella, Quaglia, Andrea, Sylla, Lakamy|||0000-0002-7114-4736, Luigi Sierra, Maria Gracia|||0000-0002-6414-0550, Amills i Eras, Marcel|||0000-0002-8999-0770, Lasagna, Emiliano
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:325592
Acceso en línea:https://ddd.uab.cat/record/325592
https://dx.doi.org/urn:doi:10.1080/1828051X.2024.2441348
Access Level:acceso abierto
Palabra clave:MSTN
Italian beef cattle breeds
Hypertrophy
Performances
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spelling Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance testColombi, Daniele|||0000-0001-5167-0459Perini, FrancescoSbarra, FiorellaQuaglia, AndreaSylla, Lakamy|||0000-0002-7114-4736Luigi Sierra, Maria Gracia|||0000-0002-6414-0550Amills i Eras, Marcel|||0000-0002-8999-0770Lasagna, EmilianoMSTNItalian beef cattle breedsHypertrophyPerformancesAmong the Italian autochthonous beef cattle breeds, Marchigiana is particularly important in terms of census and production. In this breed, a SNP inactivating the myostatin gene leads to muscular hypertrophy in the individuals homozygous for the mutated allele while heterozygous individuals have an increased muscle development. The impact of this mutation on growth rate and weight is still under debate. Moreover, there is evidence obtained in mouse that the inactivation of the myostatin gene impairs testicular development. The aim of this work was to investigate whether Marchigiana bulls carrying this mutation differ from the individuals homozygous for the wild allele in terms of production or reproduction traits recorded during the performance test. Eight of the most commercially important production traits, from a dataset of 1074 animals, alongside seven reproduction traits from 298 to 624 animals, were analysed. Statistical analysis showed that heterozygous bulls had increased muscularity compared to their normal counterparts (nominal P-value = 5.42e-24), while average daily gain, live weight, and morphological score were not significantly different. Regarding reproduction phenotypes, scrotal circumference and right testicle length were significantly reduced in heterozygous animals (nominal P-values of 7.87e-05 and 0.0018), right testicle diameter was also significantly reduced, but only at the nominal level (nominal P-value = 0.0354), while sperm volume was increased (nominal P-value = 0.01). Our results highlight the positive effect of this mutation on muscularity, while it does not show an adverse impact on other traits. Thus, the selection of heterozygous bulls in mating plans could be highly beneficial. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/325592https://dx.doi.org/urn:doi:10.1080/1828051X.2024.2441348reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3255922026-06-06T12:50:31Z
dc.title.none.fl_str_mv Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
title Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
spellingShingle Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
Colombi, Daniele|||0000-0001-5167-0459
MSTN
Italian beef cattle breeds
Hypertrophy
Performances
title_short Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
title_full Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
title_fullStr Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
title_full_unstemmed Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
title_sort Association of a mutation inactivating the myostatin gene with growth, testicular morphology and sperm quality traits measured in Marchigiana young bulls in performance test
dc.creator.none.fl_str_mv Colombi, Daniele|||0000-0001-5167-0459
Perini, Francesco
Sbarra, Fiorella
Quaglia, Andrea
Sylla, Lakamy|||0000-0002-7114-4736
Luigi Sierra, Maria Gracia|||0000-0002-6414-0550
Amills i Eras, Marcel|||0000-0002-8999-0770
Lasagna, Emiliano
author Colombi, Daniele|||0000-0001-5167-0459
author_facet Colombi, Daniele|||0000-0001-5167-0459
Perini, Francesco
Sbarra, Fiorella
Quaglia, Andrea
Sylla, Lakamy|||0000-0002-7114-4736
Luigi Sierra, Maria Gracia|||0000-0002-6414-0550
Amills i Eras, Marcel|||0000-0002-8999-0770
Lasagna, Emiliano
author_role author
author2 Perini, Francesco
Sbarra, Fiorella
Quaglia, Andrea
Sylla, Lakamy|||0000-0002-7114-4736
Luigi Sierra, Maria Gracia|||0000-0002-6414-0550
Amills i Eras, Marcel|||0000-0002-8999-0770
Lasagna, Emiliano
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MSTN
Italian beef cattle breeds
Hypertrophy
Performances
topic MSTN
Italian beef cattle breeds
Hypertrophy
Performances
description Among the Italian autochthonous beef cattle breeds, Marchigiana is particularly important in terms of census and production. In this breed, a SNP inactivating the myostatin gene leads to muscular hypertrophy in the individuals homozygous for the mutated allele while heterozygous individuals have an increased muscle development. The impact of this mutation on growth rate and weight is still under debate. Moreover, there is evidence obtained in mouse that the inactivation of the myostatin gene impairs testicular development. The aim of this work was to investigate whether Marchigiana bulls carrying this mutation differ from the individuals homozygous for the wild allele in terms of production or reproduction traits recorded during the performance test. Eight of the most commercially important production traits, from a dataset of 1074 animals, alongside seven reproduction traits from 298 to 624 animals, were analysed. Statistical analysis showed that heterozygous bulls had increased muscularity compared to their normal counterparts (nominal P-value = 5.42e-24), while average daily gain, live weight, and morphological score were not significantly different. Regarding reproduction phenotypes, scrotal circumference and right testicle length were significantly reduced in heterozygous animals (nominal P-values of 7.87e-05 and 0.0018), right testicle diameter was also significantly reduced, but only at the nominal level (nominal P-value = 0.0354), while sperm volume was increased (nominal P-value = 0.01). Our results highlight the positive effect of this mutation on muscularity, while it does not show an adverse impact on other traits. Thus, the selection of heterozygous bulls in mating plans could be highly beneficial.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/325592
https://dx.doi.org/urn:doi:10.1080/1828051X.2024.2441348
url https://ddd.uab.cat/record/325592
https://dx.doi.org/urn:doi:10.1080/1828051X.2024.2441348
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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