Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique

A nanostructured device based on poly(vinyl alcohol) (PVA) loaded with a cross-linked chitosan (CH) emulsion, soy lecithin, and peppermint essential oil (Mentha piperita) was designed for topical applications using an electrospinning instrument coupled to a rotary drum collector. Different suspensio...

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Detalhes bibliográficos
Autores: Lamarra, J., Rivero, S., Pinotti, A., López García, Daniel
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/342289
Acesso em linha:http://hdl.handle.net/10261/342289
Access Level:acceso abierto
Palavra-chave:Electrospinning
Rotating drum collector
Polyvinyl alcohol
Chitosan emulsion
Peppermint essential oil
Mentha piperita essential oil
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spelling Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning techniqueLamarra, J.Rivero, S.Pinotti, A.López García, DanielElectrospinningRotating drum collectorPolyvinyl alcoholChitosan emulsionPeppermint essential oilMentha piperita essential oilA nanostructured device based on poly(vinyl alcohol) (PVA) loaded with a cross-linked chitosan (CH) emulsion, soy lecithin, and peppermint essential oil (Mentha piperita) was designed for topical applications using an electrospinning instrument coupled to a rotary drum collector. Different suspensions were obtained by varying the PVA to emulsion ratio (PVA:Em) 87.5:12.5, 82:18, and 75:25, using a PVA solution as a control. ATR-FTIR spectra confirmed the interactions among the components of the system. Scanning electron microscopy (SEM) of the mats evinced that the aligned fiber diameter decreased with higher proportions of emulsion while dynamic mechanical analysis (DMA) revealed a decrease in the storage modulus. The entrapment of the functionalized emulsions not only improved the elongation of the matrices but also provided them with greater structural integrity compared to the single PVA matrix. The most favorable formulation in terms of mechanical properties was found to be the 82:18 ratio. After 1 h of close contact between the 82:18 matrix and a porcine skin explant, the latter was examined by confocal microscopy, which revealed the localization of the essential oil mainly on the surface of the stratum corneum (SC).However, after 7 h of contact, the distribution of the peppermint EO throughout the viable epidermis was observed, which was further supported by ATR-FTIR studies. Tailored electrospun matrices would have potential applications as devices for topical or transdermal treatments due to their vehiculization role that allows the diffusion of peppermint essential oil as a skin penetration enhancer.This work was supported by the Argentinean Agency for the Scien- tific and Technological Promotion (ANPCyT) (Projects PICT 2019- 02008 and PICT 2019-03380). Project PID2021-123753NB-C31 funded by MCIN/AEI/10.13039/501100011033 and, by “ERDF A way of making Europe”, by the “European Union”Peer reviewedElsevierAgencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Argentina)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420232024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/342289reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.ijbiomac.2023.125980Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3422892026-05-22T06:33:51Z
dc.title.none.fl_str_mv Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
title Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
spellingShingle Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
Lamarra, J.
Electrospinning
Rotating drum collector
Polyvinyl alcohol
Chitosan emulsion
Peppermint essential oil
Mentha piperita essential oil
title_short Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
title_full Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
title_fullStr Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
title_full_unstemmed Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
title_sort Nanofiber mats functionalized with Mentha piperita essential oil stabilized in a chitosan-based emulsion designed via an electrospinning technique
dc.creator.none.fl_str_mv Lamarra, J.
Rivero, S.
Pinotti, A.
López García, Daniel
author Lamarra, J.
author_facet Lamarra, J.
Rivero, S.
Pinotti, A.
López García, Daniel
author_role author
author2 Rivero, S.
Pinotti, A.
López García, Daniel
author2_role author
author
author
dc.contributor.none.fl_str_mv Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Argentina)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Electrospinning
Rotating drum collector
Polyvinyl alcohol
Chitosan emulsion
Peppermint essential oil
Mentha piperita essential oil
topic Electrospinning
Rotating drum collector
Polyvinyl alcohol
Chitosan emulsion
Peppermint essential oil
Mentha piperita essential oil
description A nanostructured device based on poly(vinyl alcohol) (PVA) loaded with a cross-linked chitosan (CH) emulsion, soy lecithin, and peppermint essential oil (Mentha piperita) was designed for topical applications using an electrospinning instrument coupled to a rotary drum collector. Different suspensions were obtained by varying the PVA to emulsion ratio (PVA:Em) 87.5:12.5, 82:18, and 75:25, using a PVA solution as a control. ATR-FTIR spectra confirmed the interactions among the components of the system. Scanning electron microscopy (SEM) of the mats evinced that the aligned fiber diameter decreased with higher proportions of emulsion while dynamic mechanical analysis (DMA) revealed a decrease in the storage modulus. The entrapment of the functionalized emulsions not only improved the elongation of the matrices but also provided them with greater structural integrity compared to the single PVA matrix. The most favorable formulation in terms of mechanical properties was found to be the 82:18 ratio. After 1 h of close contact between the 82:18 matrix and a porcine skin explant, the latter was examined by confocal microscopy, which revealed the localization of the essential oil mainly on the surface of the stratum corneum (SC).However, after 7 h of contact, the distribution of the peppermint EO throughout the viable epidermis was observed, which was further supported by ATR-FTIR studies. Tailored electrospun matrices would have potential applications as devices for topical or transdermal treatments due to their vehiculization role that allows the diffusion of peppermint essential oil as a skin penetration enhancer.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/342289
url http://hdl.handle.net/10261/342289
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.ijbiomac.2023.125980
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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