Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases

An epidemiological relationship between urolithiasis and cardiovascular diseases has extensively been reported. Endothelial dysfunction is an early pathogenic event in cardiovascular diseases and has been associated with oxidative stress and low chronic inflammation in hypertension, coronary heart d...

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Autores: Saenz-Medina, Javier, Muñoz Picos, Mercedes, Rodríguez Prados, Claudia, Sánchez Pina, Ana Alejandra, Contreras Jiménez, Cristina, Carballido-Rodríguez, Joaquín, Prieto Ocejo, Dolores
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/125039
Acceso en línea:https://hdl.handle.net/20.500.14352/125039
Access Level:acceso abierto
Palabra clave:612
616.61
Endothelial dysfunction
Oxidative stress
Urolithiasis
Kidney stones
Fisiología animal (Farmacia)
Nefrología y urología
3206.02 Metabolismo Energético
2411.04 Fisiología Endocrina
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oai_identifier_str oai:docta.ucm.es:20.500.14352/125039
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repository_id_str
spelling Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular DiseasesSaenz-Medina, JavierMuñoz Picos, MercedesRodríguez Prados, ClaudiaSánchez Pina, Ana AlejandraContreras Jiménez, CristinaCarballido-Rodríguez, JoaquínPrieto Ocejo, Dolores612616.61Endothelial dysfunctionOxidative stressUrolithiasisKidney stonesFisiología animal (Farmacia)Nefrología y urología3206.02 Metabolismo Energético2411.04 Fisiología EndocrinaAn epidemiological relationship between urolithiasis and cardiovascular diseases has extensively been reported. Endothelial dysfunction is an early pathogenic event in cardiovascular diseases and has been associated with oxidative stress and low chronic inflammation in hypertension, coronary heart disease, stroke or the vascular complications of diabetes and obesity. The aim of this study is to summarize the current knowledge about the pathogenic mechanisms of urolithiasis in relation to the development of endothelial dysfunction and cardiovascular morbidities. Methods: A non-systematic review has been performed mixing the terms “urolithiasis”, “kidney stone” or “nephrolithiasis” with “cardiovascular disease”, “myocardial infarction”, “stroke”, or “endothelial dysfunction”. Results: Patients with nephrolithiasis develop a higher incidence of cardiovascular disease with a relative risk estimated between 1.20 and 1.24 and also develop a higher vascular disease risk scores. Analyses of subgroups have rendered inconclusive results regarding gender or age. Endothelial dysfunction has also been strongly associated with urolithiasis in clinical studies, although no systemic serum markers of endothelial dysfunction, inflammation or oxidative stress could be clearly related. Analysis of urine composition of lithiasic patients also detected a higher expression of proteins related to cardiovascular disease. Experimental models of hyperoxaluria have also found elevation of serum endothelial dysfunction markers. Conclusions: Endothelial dysfunction has been strongly associated with urolithiasis and based on the experimental evidence, should be considered as an intermediate and changeable feature between urolithiasis and cardiovascular diseases. Oxidative stress, a key pathogenic factor in the development of endothelial dysfunction has been also pointed out as an important factor of lithogenesis. Special attention must be paid to cardiovascular morbidities associated with urolithiasis in order to take advantage of pleiotropic effects of statins, angiotensin receptor blockers and allopurinol.MDPIUniversidad Complutense de Madrid20222022-01-1420222022-01-14review articlehttp://purl.org/coar/resource_type/c_dcae04bcAMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/125039reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1250392026-06-02T12:44:21Z
dc.title.none.fl_str_mv Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
title Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
spellingShingle Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
Saenz-Medina, Javier
612
616.61
Endothelial dysfunction
Oxidative stress
Urolithiasis
Kidney stones
Fisiología animal (Farmacia)
Nefrología y urología
3206.02 Metabolismo Energético
2411.04 Fisiología Endocrina
title_short Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
title_full Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
title_fullStr Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
title_full_unstemmed Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
title_sort Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases
dc.creator.none.fl_str_mv Saenz-Medina, Javier
Muñoz Picos, Mercedes
Rodríguez Prados, Claudia
Sánchez Pina, Ana Alejandra
Contreras Jiménez, Cristina
Carballido-Rodríguez, Joaquín
Prieto Ocejo, Dolores
author Saenz-Medina, Javier
author_facet Saenz-Medina, Javier
Muñoz Picos, Mercedes
Rodríguez Prados, Claudia
Sánchez Pina, Ana Alejandra
Contreras Jiménez, Cristina
Carballido-Rodríguez, Joaquín
Prieto Ocejo, Dolores
author_role author
author2 Muñoz Picos, Mercedes
Rodríguez Prados, Claudia
Sánchez Pina, Ana Alejandra
Contreras Jiménez, Cristina
Carballido-Rodríguez, Joaquín
Prieto Ocejo, Dolores
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612
616.61
Endothelial dysfunction
Oxidative stress
Urolithiasis
Kidney stones
Fisiología animal (Farmacia)
Nefrología y urología
3206.02 Metabolismo Energético
2411.04 Fisiología Endocrina
topic 612
616.61
Endothelial dysfunction
Oxidative stress
Urolithiasis
Kidney stones
Fisiología animal (Farmacia)
Nefrología y urología
3206.02 Metabolismo Energético
2411.04 Fisiología Endocrina
description An epidemiological relationship between urolithiasis and cardiovascular diseases has extensively been reported. Endothelial dysfunction is an early pathogenic event in cardiovascular diseases and has been associated with oxidative stress and low chronic inflammation in hypertension, coronary heart disease, stroke or the vascular complications of diabetes and obesity. The aim of this study is to summarize the current knowledge about the pathogenic mechanisms of urolithiasis in relation to the development of endothelial dysfunction and cardiovascular morbidities. Methods: A non-systematic review has been performed mixing the terms “urolithiasis”, “kidney stone” or “nephrolithiasis” with “cardiovascular disease”, “myocardial infarction”, “stroke”, or “endothelial dysfunction”. Results: Patients with nephrolithiasis develop a higher incidence of cardiovascular disease with a relative risk estimated between 1.20 and 1.24 and also develop a higher vascular disease risk scores. Analyses of subgroups have rendered inconclusive results regarding gender or age. Endothelial dysfunction has also been strongly associated with urolithiasis in clinical studies, although no systemic serum markers of endothelial dysfunction, inflammation or oxidative stress could be clearly related. Analysis of urine composition of lithiasic patients also detected a higher expression of proteins related to cardiovascular disease. Experimental models of hyperoxaluria have also found elevation of serum endothelial dysfunction markers. Conclusions: Endothelial dysfunction has been strongly associated with urolithiasis and based on the experimental evidence, should be considered as an intermediate and changeable feature between urolithiasis and cardiovascular diseases. Oxidative stress, a key pathogenic factor in the development of endothelial dysfunction has been also pointed out as an important factor of lithogenesis. Special attention must be paid to cardiovascular morbidities associated with urolithiasis in order to take advantage of pleiotropic effects of statins, angiotensin receptor blockers and allopurinol.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-14
2022
2022-01-14
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/125039
url https://hdl.handle.net/20.500.14352/125039
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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