Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies

Càncer; Immunoteràpia; Radioteràpia

Detalles Bibliográficos
Autores: Benavente Norza, Sergio, Sanchez Garcia, Almudena, Naches Garcia, Silvia, Lorente Guerrero, Juan, Lleonart Pajarin, Matilde
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/6301
Acceso en línea:https://hdl.handle.net/11351/6301
Access Level:acceso abierto
Palabra clave:Càncer - Tractament
Fisiologia cel·lular
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
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spelling Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer TherapiesBenavente Norza, SergioSanchez Garcia, AlmudenaNaches Garcia, SilviaLorente Guerrero, JuanLleonart Pajarin, MatildeCàncer - TractamentFisiologia cel·lularPHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor MicroenvironmentDISEASES::NeoplasmsOther subheadings::Other subheadings::/therapyFENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoralENFERMEDADES::neoplasiasOtros calificadores::Otros calificadores::/terapiaCàncer; Immunoteràpia; RadioteràpiaCáncer; Inmunoterapia; RadioterapiaCancer; Immunotherapy; RadiotherapyAdvances in immunotherapy have achieved remarkable clinical outcomes in tumors with low curability, but their effects are limited, and increasing evidence has implicated tumoral and non-tumoral components of the tumor microenvironment as critical mediators of cancer progression. At the same time, the clinical successes achieved with minimally invasive and optically-guided surgery and image-guided and ablative radiation strategies have been successfully implemented in clinical care. More effective, localized and safer treatments have fueled strong research interest in radioimmunotherapy, which has shown the potential immunomodulatory effects of ionizing radiation. However, increasingly more observations suggest that immunosuppressive changes, metabolic remodeling, and angiogenic responses in the local tumor microenvironment play a central role in tumor recurrence. In this review, we address challenges to identify responders vs. non-responders to the immune checkpoint blockade, discuss recent developments in combinations of immunotherapy and radiotherapy for clinical evaluation, and consider the clinical impact of immunosuppressive changes in the tumor microenvironment in the context of surgery and radiation. Since the therapy-induced modulation of the tumor microenvironment presents a multiplicity of forms, we propose that overcoming microenvironment related resistance can become clinically relevant and represents a novel strategy to optimize treatment immunogenicity and improve patient outcome.This work was supported by grants from the Instituto de Salud Carlos III (ISCIII): PI15/01262 (ML) and CP03/00101 (ML), co-financed by the European Regional Fund (ERDF) and AECC (Spanish Association of Cancer Research) Founding Ref. GC16173720CARR (ML). AS-G was granted by VHIR fellowships.Frontiers MediaInstitut Català de la Salut[Benavente S] Servei d’Oncologia Radioteràpica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Sánchez-García A] Grup de Recerca biomèdica amb cèl·lules mare del càncer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Naches S, Lorente J] Servei d’Otorrinolaringologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [LLeonart ME] Grup de Recerca biomèdica amb cèl·lules mare del càncer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Spanish Biomedical Research Network Centre in Oncology, CIBERONC, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6301Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Oncology;10https://doi.org/10.3389/fonc.2020.582884info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F01262Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/63012026-05-29T05:05:01Z
dc.title.none.fl_str_mv Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
title Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
spellingShingle Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
Benavente Norza, Sergio
Càncer - Tractament
Fisiologia cel·lular
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
title_short Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
title_full Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
title_fullStr Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
title_full_unstemmed Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
title_sort Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies
dc.creator.none.fl_str_mv Benavente Norza, Sergio
Sanchez Garcia, Almudena
Naches Garcia, Silvia
Lorente Guerrero, Juan
Lleonart Pajarin, Matilde
author Benavente Norza, Sergio
author_facet Benavente Norza, Sergio
Sanchez Garcia, Almudena
Naches Garcia, Silvia
Lorente Guerrero, Juan
Lleonart Pajarin, Matilde
author_role author
author2 Sanchez Garcia, Almudena
Naches Garcia, Silvia
Lorente Guerrero, Juan
Lleonart Pajarin, Matilde
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Benavente S] Servei d’Oncologia Radioteràpica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Sánchez-García A] Grup de Recerca biomèdica amb cèl·lules mare del càncer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Naches S, Lorente J] Servei d’Otorrinolaringologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [LLeonart ME] Grup de Recerca biomèdica amb cèl·lules mare del càncer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Spanish Biomedical Research Network Centre in Oncology, CIBERONC, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Càncer - Tractament
Fisiologia cel·lular
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
topic Càncer - Tractament
Fisiologia cel·lular
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
description Càncer; Immunoteràpia; Radioteràpia
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/6301
url https://hdl.handle.net/11351/6301
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Oncology;10
https://doi.org/10.3389/fonc.2020.582884
info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F01262
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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