Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?

Background: in type 1 diabetes, telomere length (TL) may predict complications and could be influenced by glycaemic control and physical activity, but its relationship with physical fitness in youths remains unexplored. The aim of the study was to assess the association between physical fitness and...

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Autores: Muñoz Pardeza, Jacinto, López Gil, José Francisco, Huerta Uribe, Nidia, Hormazábal Aguayo, Ignacio, Ojeda-Rodríguez, Ana, Martí del Moral, Amelia, Izquierdo Redín, Mikel, García Hermoso, Antonio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/53273
Acceso en línea:https://hdl.handle.net/2454/53273
Access Level:acceso abierto
Palabra clave:Exercise
Diabetes
Endocrinology
Genetics
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spelling Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?Muñoz Pardeza, JacintoLópez Gil, José FranciscoHuerta Uribe, NidiaHormazábal Aguayo, IgnacioOjeda-Rodríguez, AnaMartí del Moral, AmeliaIzquierdo Redín, MikelGarcía Hermoso, AntonioExerciseDiabetesEndocrinologyGeneticsBackground: in type 1 diabetes, telomere length (TL) may predict complications and could be influenced by glycaemic control and physical activity, but its relationship with physical fitness in youths remains unexplored. The aim of the study was to assess the association between physical fitness and TL in youth with type 1 diabetes, both at baseline and one year later. Methods: eighty-three children and adolescents (aged 6-18 years; 44.6% girls) with type 1 diabetes from the Diactive-1 Cohort Study were involved in this study. Physical fitness was assessed using spirometry on a cycloergometer (i.e., peak oxygen consumption), dynamometry, and maximal isometric strength (one-repetition maximum [1RM]), and muscle power. Leucocyte TL was assessed using multiplex monochrome real-time quantitative polymerase chain reaction. Results: positive cross-sectional associations were identified between 1RM (unstandardized beta coefficient [B] = 0.042, 95% bias corrected and accelerated [BCa] confidence interval [CI] 0.012-0.069), muscle power (B = 0.056, 95% BCa CI 0.02-0.250), and overall physical fitness (B = 0.043, 95% BCa CI 0.015¿0.071) with TL independent of maturation, glycated haemoglobin, and diabetes duration. However, no associations were observed one year later. Conclusion: higher levels of fitness, particularly muscle strength, may play a role in telomere dynamics in youth with type 1 diabetes, suggesting that strength training exercise could be beneficial. Impact: this is the first study to examine cross-sectional and longitudinal perspectives on the correlation among muscle strength, peak oxygen consumption [VO2peak] and telomere length in youths with type 1 diabetes. Higher physical fitness levels, as assessed by measures such as one-repetition maximum, muscle power, and overall physical fitness, are positively associated with telomere length in youths with type 1 diabetes. Understanding this link could improve management strategies, prioritizing muscle strength training for better long-term health in type 1 diabetes.This study was funded by grant PI21/01238 from the Instituto de Salud Carlos III (Spain) and by CIBER of Obesity Physiology and Nutrition (CB12/03/30002). The project that gave rise to these results received the support of a fellowship form 'Instituto de Salud Carlos III' granted to Jacinto Muñoz-Pardeza (FI22/00329). Dr. Ana Ojeda-Rodriguez is the recipient of a Sara Borrell grant (CD21/00099) from the Instituto de Salud Carlos III. The origin of obtaining results was supported by a scholarship from the 'la Caixa' Foundation awarded to Nidia Huerta Uribe.SpringerCiencias de la SaludOsasun Zientziak2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/53273reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F01238info:eu-repo/grantAgreement/MINECO//CB12%2F03%2F30002info:eu-repo/grantAgreement/ISCIII/Plan Estratégico de Investigación Científica, Técnica y de Innovación 2021-2023/FI22%2F00329© 2024, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/532732026-06-17T12:41:47Z
dc.title.none.fl_str_mv Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
title Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
spellingShingle Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
Muñoz Pardeza, Jacinto
Exercise
Diabetes
Endocrinology
Genetics
title_short Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
title_full Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
title_fullStr Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
title_full_unstemmed Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
title_sort Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?
dc.creator.none.fl_str_mv Muñoz Pardeza, Jacinto
López Gil, José Francisco
Huerta Uribe, Nidia
Hormazábal Aguayo, Ignacio
Ojeda-Rodríguez, Ana
Martí del Moral, Amelia
Izquierdo Redín, Mikel
García Hermoso, Antonio
author Muñoz Pardeza, Jacinto
author_facet Muñoz Pardeza, Jacinto
López Gil, José Francisco
Huerta Uribe, Nidia
Hormazábal Aguayo, Ignacio
Ojeda-Rodríguez, Ana
Martí del Moral, Amelia
Izquierdo Redín, Mikel
García Hermoso, Antonio
author_role author
author2 López Gil, José Francisco
Huerta Uribe, Nidia
Hormazábal Aguayo, Ignacio
Ojeda-Rodríguez, Ana
Martí del Moral, Amelia
Izquierdo Redín, Mikel
García Hermoso, Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Exercise
Diabetes
Endocrinology
Genetics
topic Exercise
Diabetes
Endocrinology
Genetics
description Background: in type 1 diabetes, telomere length (TL) may predict complications and could be influenced by glycaemic control and physical activity, but its relationship with physical fitness in youths remains unexplored. The aim of the study was to assess the association between physical fitness and TL in youth with type 1 diabetes, both at baseline and one year later. Methods: eighty-three children and adolescents (aged 6-18 years; 44.6% girls) with type 1 diabetes from the Diactive-1 Cohort Study were involved in this study. Physical fitness was assessed using spirometry on a cycloergometer (i.e., peak oxygen consumption), dynamometry, and maximal isometric strength (one-repetition maximum [1RM]), and muscle power. Leucocyte TL was assessed using multiplex monochrome real-time quantitative polymerase chain reaction. Results: positive cross-sectional associations were identified between 1RM (unstandardized beta coefficient [B] = 0.042, 95% bias corrected and accelerated [BCa] confidence interval [CI] 0.012-0.069), muscle power (B = 0.056, 95% BCa CI 0.02-0.250), and overall physical fitness (B = 0.043, 95% BCa CI 0.015¿0.071) with TL independent of maturation, glycated haemoglobin, and diabetes duration. However, no associations were observed one year later. Conclusion: higher levels of fitness, particularly muscle strength, may play a role in telomere dynamics in youth with type 1 diabetes, suggesting that strength training exercise could be beneficial. Impact: this is the first study to examine cross-sectional and longitudinal perspectives on the correlation among muscle strength, peak oxygen consumption [VO2peak] and telomere length in youths with type 1 diabetes. Higher physical fitness levels, as assessed by measures such as one-repetition maximum, muscle power, and overall physical fitness, are positively associated with telomere length in youths with type 1 diabetes. Understanding this link could improve management strategies, prioritizing muscle strength training for better long-term health in type 1 diabetes.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/53273
url https://hdl.handle.net/2454/53273
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F01238
info:eu-repo/grantAgreement/MINECO//CB12%2F03%2F30002
info:eu-repo/grantAgreement/ISCIII/Plan Estratégico de Investigación Científica, Técnica y de Innovación 2021-2023/FI22%2F00329
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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