Pinning of tumoral growth by enhancement of the immune response

Tumor growth is a surface phenomenon of the molecular beam epitaxy universality class in which diffusion at the surface is the determining factor. This Letter reports experiments performed in mice showing that these dynamics can, however, be changed. By stimulating the immune response, we induced st...

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Detalles Bibliográficos
Autores: Bru Espino, Antonio Leonardo, Albertos, Sonia, López García-Asenjo, J. A., Brú, Isabel
Tipo de recurso: artículo
Fecha de publicación:2004
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:español
OAI Identifier:oai:docta.ucm.es:20.500.14352/49843
Acceso en línea:https://hdl.handle.net/20.500.14352/49843
Access Level:acceso abierto
Palabra clave:517.986.6
Interface
Dynamics
Models
Continuum
Análisis matemático
1202 Análisis y Análisis Funcional
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spelling Pinning of tumoral growth by enhancement of the immune responseBru Espino, Antonio LeonardoAlbertos, SoniaLópez García-Asenjo, J. A.Brú, Isabel517.986.6InterfaceDynamicsModelsContinuumAnálisis matemático1202 Análisis y Análisis FuncionalTumor growth is a surface phenomenon of the molecular beam epitaxy universality class in which diffusion at the surface is the determining factor. This Letter reports experiments performed in mice showing that these dynamics can, however, be changed. By stimulating the immune response, we induced strong neutrophilia around the tumor. The neutrophils hindered cell surface diffusion so much that they induced new dynamics compatible with the slower quenched-disorder Edwards-Wilkinson universality class. Important clinical effects were also seen, including remarkably high tumor necrosis (around 80%-90% of the tumor), a general increase in survival time [the death ratio in the control group is 15.76 times higher than in the treated group (equivalent to a Cox's model hazard ratio of 0.85; 95% confidence interval 0.76-0.95, p=0.004)], and even the total elimination of some tumors.American Physical SocietyUniversidad Complutense de Madrid20042004-01-0120042004-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/49843reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/498432026-06-02T12:44:21Z
dc.title.none.fl_str_mv Pinning of tumoral growth by enhancement of the immune response
title Pinning of tumoral growth by enhancement of the immune response
spellingShingle Pinning of tumoral growth by enhancement of the immune response
Bru Espino, Antonio Leonardo
517.986.6
Interface
Dynamics
Models
Continuum
Análisis matemático
1202 Análisis y Análisis Funcional
title_short Pinning of tumoral growth by enhancement of the immune response
title_full Pinning of tumoral growth by enhancement of the immune response
title_fullStr Pinning of tumoral growth by enhancement of the immune response
title_full_unstemmed Pinning of tumoral growth by enhancement of the immune response
title_sort Pinning of tumoral growth by enhancement of the immune response
dc.creator.none.fl_str_mv Bru Espino, Antonio Leonardo
Albertos, Sonia
López García-Asenjo, J. A.
Brú, Isabel
author Bru Espino, Antonio Leonardo
author_facet Bru Espino, Antonio Leonardo
Albertos, Sonia
López García-Asenjo, J. A.
Brú, Isabel
author_role author
author2 Albertos, Sonia
López García-Asenjo, J. A.
Brú, Isabel
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 517.986.6
Interface
Dynamics
Models
Continuum
Análisis matemático
1202 Análisis y Análisis Funcional
topic 517.986.6
Interface
Dynamics
Models
Continuum
Análisis matemático
1202 Análisis y Análisis Funcional
description Tumor growth is a surface phenomenon of the molecular beam epitaxy universality class in which diffusion at the surface is the determining factor. This Letter reports experiments performed in mice showing that these dynamics can, however, be changed. By stimulating the immune response, we induced strong neutrophilia around the tumor. The neutrophils hindered cell surface diffusion so much that they induced new dynamics compatible with the slower quenched-disorder Edwards-Wilkinson universality class. Important clinical effects were also seen, including remarkably high tumor necrosis (around 80%-90% of the tumor), a general increase in survival time [the death ratio in the control group is 15.76 times higher than in the treated group (equivalent to a Cox's model hazard ratio of 0.85; 95% confidence interval 0.76-0.95, p=0.004)], and even the total elimination of some tumors.
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01
2004
2004-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/49843
url https://hdl.handle.net/20.500.14352/49843
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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