Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials

An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed “mitochondrial nutrients” (MN), such as α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and l-carnitine (CARN) (or its derivatives) have been tested in a...

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Autores: Pagano, Giovanni, Talamanca, Annita Aiello, Castello, Giuseppe, Cordero Morales, Mario David, d'Ischia, Marco, Gadaleta, Maria Nicola
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/78954
Acceso en línea:https://hdl.handle.net/11441/78954
Access Level:acceso abierto
Palabra clave:Mitochondrial nutrients
Mitochondrial dysfunction
Oxidative stress
Oxidative phosphorylation
Krebs cycle
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spelling Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trialsPagano, GiovanniTalamanca, Annita AielloCastello, GiuseppeCordero Morales, Mario Davidd'Ischia, MarcoGadaleta, Maria NicolaMitochondrial nutrientsMitochondrial dysfunctionOxidative stressOxidative phosphorylationKrebs cycleAn extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed “mitochondrial nutrients” (MN), such as α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and l-carnitine (CARN) (or its derivatives) have been tested in a number of clinical trials, and this review is focused on the use of MN-based clinical trials. The papers reporting on MN-based clinical trials were retrieved in MedLine up to July 2014, and evaluated for the following endpoints: (a) treated diseases; (b) dosages, number of enrolled patients and duration of treatment; (c) trial success for each MN or MN combinations as reported by authors. The reports satisfying the above endpoints included total numbers of trials and frequencies of randomized, controlled studies, i.e., 81 trials testing ALA, 107 reports testing CoQ10, and 74 reports testing CARN, while only 7 reports were retrieved testing double MN associations, while no report was found testing a triple MN combination. A total of 28 reports tested MN associations with “classical” antioxidants, such as antioxidant nutrients or drugs. Combinations of MN showed better outcomes than individual MN, suggesting forthcoming clinical studies. The criteria in study design and monitoring MN-based clinical trials are discussed.MDPI AGEstomatologíaCTS113: Investigacion Etiologia y Patogenia Periodontal, Patologia Oral y Enfermedades Musculares2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/78954reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Molecular Sciences, 5 (11), 19330-21602.info:eu-repo/semantics/openAccessoai:idus.us.es:11441/789542026-06-17T12:51:07Z
dc.title.none.fl_str_mv Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
title Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
spellingShingle Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
Pagano, Giovanni
Mitochondrial nutrients
Mitochondrial dysfunction
Oxidative stress
Oxidative phosphorylation
Krebs cycle
title_short Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
title_full Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
title_fullStr Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
title_full_unstemmed Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
title_sort Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials
dc.creator.none.fl_str_mv Pagano, Giovanni
Talamanca, Annita Aiello
Castello, Giuseppe
Cordero Morales, Mario David
d'Ischia, Marco
Gadaleta, Maria Nicola
author Pagano, Giovanni
author_facet Pagano, Giovanni
Talamanca, Annita Aiello
Castello, Giuseppe
Cordero Morales, Mario David
d'Ischia, Marco
Gadaleta, Maria Nicola
author_role author
author2 Talamanca, Annita Aiello
Castello, Giuseppe
Cordero Morales, Mario David
d'Ischia, Marco
Gadaleta, Maria Nicola
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Estomatología
CTS113: Investigacion Etiologia y Patogenia Periodontal, Patologia Oral y Enfermedades Musculares
dc.subject.none.fl_str_mv Mitochondrial nutrients
Mitochondrial dysfunction
Oxidative stress
Oxidative phosphorylation
Krebs cycle
topic Mitochondrial nutrients
Mitochondrial dysfunction
Oxidative stress
Oxidative phosphorylation
Krebs cycle
description An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed “mitochondrial nutrients” (MN), such as α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and l-carnitine (CARN) (or its derivatives) have been tested in a number of clinical trials, and this review is focused on the use of MN-based clinical trials. The papers reporting on MN-based clinical trials were retrieved in MedLine up to July 2014, and evaluated for the following endpoints: (a) treated diseases; (b) dosages, number of enrolled patients and duration of treatment; (c) trial success for each MN or MN combinations as reported by authors. The reports satisfying the above endpoints included total numbers of trials and frequencies of randomized, controlled studies, i.e., 81 trials testing ALA, 107 reports testing CoQ10, and 74 reports testing CARN, while only 7 reports were retrieved testing double MN associations, while no report was found testing a triple MN combination. A total of 28 reports tested MN associations with “classical” antioxidants, such as antioxidant nutrients or drugs. Combinations of MN showed better outcomes than individual MN, suggesting forthcoming clinical studies. The criteria in study design and monitoring MN-based clinical trials are discussed.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/78954
url https://hdl.handle.net/11441/78954
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences, 5 (11), 19330-21602.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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