Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. The severity of COVID-19 increases with each decade of life, a phenomenon that suggest that organismal aging contributes to the fatality of the disease. In this regar...

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Autores: Martínez, Paula, Sánchez-Vázquez, Raúl, Saha, Arpita, Rodriguez-Duque, Maria S., Naranjo-Gonzalo, Sara, Osorio-Chávez, Joy S., Villar Ramos, Ana V., Blasco, María A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::9d86eaf62fa1ea1014ee812d241a041a
Acceso en línea:http://hdl.handle.net/10261/348401
Access Level:acceso abierto
Palabra clave:ATII cells
Lung fibrosis
Telomeres
COVID-19
SARS-CoV2
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spelling Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancerMartínez, PaulaSánchez-Vázquez, RaúlSaha, ArpitaRodriguez-Duque, Maria S.Naranjo-Gonzalo, SaraOsorio-Chávez, Joy S.Villar Ramos, Ana V.Blasco, María A.ATII cellsLung fibrosisTelomeresCOVID-19SARS-CoV2The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. The severity of COVID-19 increases with each decade of life, a phenomenon that suggest that organismal aging contributes to the fatality of the disease. In this regard, we and others have previously shown that COVID-19 severity correlates with shorter telomeres, a molecular determinant of aging, in patient’s leukocytes. Lung injury is a predominant feature of acute SARS-CoV-2 infection that can further progress to lung fibrosis in post-COVID-19 patients. Short or dysfunctional telomeres in Alveolar type II (ATII) cells are sufficient to induce pulmonary fibrosis in mouse and humans. Here, we analyze telomere length and the histopathology of lung biopsies from a cohort of alive post-COVID-19 patients and a cohort of age-matched controls with lung cancer. We found loss of ATII cellularity and shorter telomeres in ATII cells concomitant with a marked increase in fibrotic lung parenchyma remodeling in post- COVID-19 patients compared to controls. These findings reveal a link between presence of short telomeres in ATII cells and long-term lung fibrosis sequel in Post-COVID-19 patients.Research in the Blasco Lab is funded byFundación Botín and Banco Santander (Spain); Agencia Estatal de Investigación (AEI/MCI/10.13039/501100011033) with the project RETOS SAF2017-82623-R, cofunded by European Regional Development Fund (ERDF), “A way of making Europe”; Comunidad de Madrid with the Synergy Project COVIDPREclinicalMODels-CM and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 882385) through the project ERC-AvG SHELTERINS. The CNIO, certified since 2011 as Severo Ochoa Centre of Excellence by AEI/MCI/10.13039/501100011033, is supported by the Spanish Government through the Instituto de Salud Carlos III (ISCIII). Research in the Villar Lab is funded by Agencia Estatal de Investigación RTI2018-095214-B-I00, Gobierno de Cantabria SUBVTC-2021-0011, Fomento de la transferencia de conocimiento en la Comunidad Autónoma de Cantabria 2020UCI22-PUB-000 and by Fundación IDIVAL INNVAL20/34.Peer reviewedImpact JournalsFundación BotínBanco SantanderAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Comunidad de MadridEuropean Research CouncilEuropean CommissionInstituto de Salud Carlos IIIGobierno de CantabriaInstituto de Investigación Marqués de ValdecillaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420232024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/348401reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82623-Rinfo:eu-repo/grantAgreement/EC/H2020/882385info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095214-B-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.18632/aging.204755http://dx.doi.org/10.18632/aging.204755Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::9d86eaf62fa1ea1014ee812d241a041a2026-05-22T06:33:51Z
dc.title.none.fl_str_mv Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
title Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
spellingShingle Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
Martínez, Paula
ATII cells
Lung fibrosis
Telomeres
COVID-19
SARS-CoV2
title_short Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
title_full Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
title_fullStr Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
title_full_unstemmed Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
title_sort Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
dc.creator.none.fl_str_mv Martínez, Paula
Sánchez-Vázquez, Raúl
Saha, Arpita
Rodriguez-Duque, Maria S.
Naranjo-Gonzalo, Sara
Osorio-Chávez, Joy S.
Villar Ramos, Ana V.
Blasco, María A.
author Martínez, Paula
author_facet Martínez, Paula
Sánchez-Vázquez, Raúl
Saha, Arpita
Rodriguez-Duque, Maria S.
Naranjo-Gonzalo, Sara
Osorio-Chávez, Joy S.
Villar Ramos, Ana V.
Blasco, María A.
author_role author
author2 Sánchez-Vázquez, Raúl
Saha, Arpita
Rodriguez-Duque, Maria S.
Naranjo-Gonzalo, Sara
Osorio-Chávez, Joy S.
Villar Ramos, Ana V.
Blasco, María A.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Botín
Banco Santander
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Comunidad de Madrid
European Research Council
European Commission
Instituto de Salud Carlos III
Gobierno de Cantabria
Instituto de Investigación Marqués de Valdecilla
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv ATII cells
Lung fibrosis
Telomeres
COVID-19
SARS-CoV2
topic ATII cells
Lung fibrosis
Telomeres
COVID-19
SARS-CoV2
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. The severity of COVID-19 increases with each decade of life, a phenomenon that suggest that organismal aging contributes to the fatality of the disease. In this regard, we and others have previously shown that COVID-19 severity correlates with shorter telomeres, a molecular determinant of aging, in patient’s leukocytes. Lung injury is a predominant feature of acute SARS-CoV-2 infection that can further progress to lung fibrosis in post-COVID-19 patients. Short or dysfunctional telomeres in Alveolar type II (ATII) cells are sufficient to induce pulmonary fibrosis in mouse and humans. Here, we analyze telomere length and the histopathology of lung biopsies from a cohort of alive post-COVID-19 patients and a cohort of age-matched controls with lung cancer. We found loss of ATII cellularity and shorter telomeres in ATII cells concomitant with a marked increase in fibrotic lung parenchyma remodeling in post- COVID-19 patients compared to controls. These findings reveal a link between presence of short telomeres in ATII cells and long-term lung fibrosis sequel in Post-COVID-19 patients.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/348401
url http://hdl.handle.net/10261/348401
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82623-R
info:eu-repo/grantAgreement/EC/H2020/882385
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095214-B-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.18632/aging.204755
http://dx.doi.org/10.18632/aging.204755
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
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instname:Consejo Superior de Investigaciones Científicas (CSIC)
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