Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study

Martín-García-Sancho, A. (Alejandro)|||/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548; Bellei, M. (Monica)|||/items/066f8838-ec5c-4121-ad8f-2976d2f946a9; Lopez-Parra, M. (Miriam)|||/items/5e1bb5db-95e6-4107-ab31-89287abeb248; Gritti, G. (Giuseppe)|||/items/9978abb8-e9da-4b73-8705-3d5cec449ce9; Cortés, M. (María)|||/items/f6b827b1-1288-4db3-b09c-e762bab4203d; Novelli, S. (Silvana)|||/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4; Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b; Petrucci, L. (Luigi)|||/items/2d1b869f-552b-4598-b07f-632a05466b75; Gutierrez, A. (Antonio)|||/items/cd08206a-1bde-4f25-a9e4-681014c712be; Dlouhy, I. (Ivan)|||/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c; Bastos-Oreiro, M. (Mariana)|||/items/9798d413-d64d-4b19-b5cf-7987a1d80938; Sancho, J. M. (Juan Manuel)|||/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea; Ramírez, M.J. (Maria José)|||/items/3c833d8f-d679-4602-828e-cd218813027a; Moraleda, J.M. (Jose Maria)|||/items/6a96c554-773d-428a-9003-41d37bb21477; Carrillo-Cruz, E. (Estrella)|||/items/e7430696-2680-4a72-905a-4e87a3322605; Jiménez-Ubieto, A. (Ana)|||/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5; Jarque, I. (Isidro)|||/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3; Orsucci, L. (Lorella)|||/items/2d616949-b7b7-46f0-9692-646217b3477a; Garcia-Torres, E. (Estefania)|||/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8; Montalbán, C. (Carlos)|||/items/7c7c01be-65ba-416a-a29b-b05f212c1b27; Dodero, A. (Anna)|||/items/29078649-9179-4f2a-a305-9827711d4b27; Arranz, R. (Reyes)|||/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5; Heras, N. (Natalia) de las|||/items/f8e78df7-bc72-404d-8122-60fc2976c701; Pascual-Cascon, M.J. (Maria Jesus)|||/items/f0290602-545e-4756-b526-32b6d56ff0ae; López-Jiménez, J. (Javier)|||/items/33646694-560a-48b0-a994-709826c7ff4d; Spina, M. (Michelle)|||/items/45b7854c-ef1d-4f3c-a700-a29398e1363f; Re, A. (Alessandro)|||/items/cc3b8cee-c417-4ff9-bd9b-58990744667f; González de Villambrosía, S. (Sonia)|||/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e; Bobillo, S. (Sabella)|||/items/31e94435-1f28-46db-a819-dcdb5f89afb8; Federico, M. (Massimo)|||/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8

Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study

Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigat...

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Autores:	Martín-García-Sancho, A. (Alejandro)\|\|\|/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548, Bellei, M. (Monica)\|\|\|/items/066f8838-ec5c-4121-ad8f-2976d2f946a9, Lopez-Parra, M. (Miriam)\|\|\|/items/5e1bb5db-95e6-4107-ab31-89287abeb248, Gritti, G. (Giuseppe)\|\|\|/items/9978abb8-e9da-4b73-8705-3d5cec449ce9, Cortés, M. (María)\|\|\|/items/f6b827b1-1288-4db3-b09c-e762bab4203d, Novelli, S. (Silvana)\|\|\|/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4, Panizo, C. (Carlos)\|\|\|/items/a5fb9193-be12-418c-9a99-929473b7bb3b, Petrucci, L. (Luigi)\|\|\|/items/2d1b869f-552b-4598-b07f-632a05466b75, Gutierrez, A. (Antonio)\|\|\|/items/cd08206a-1bde-4f25-a9e4-681014c712be, Dlouhy, I. (Ivan)\|\|\|/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c, Bastos-Oreiro, M. (Mariana)\|\|\|/items/9798d413-d64d-4b19-b5cf-7987a1d80938, Sancho, J. M. (Juan Manuel)\|\|\|/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea, Ramírez, M.J. (Maria José)\|\|\|/items/3c833d8f-d679-4602-828e-cd218813027a, Moraleda, J.M. (Jose Maria)\|\|\|/items/6a96c554-773d-428a-9003-41d37bb21477, Carrillo-Cruz, E. (Estrella)\|\|\|/items/e7430696-2680-4a72-905a-4e87a3322605, Jiménez-Ubieto, A. (Ana)\|\|\|/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5, Jarque, I. (Isidro)\|\|\|/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3, Orsucci, L. (Lorella)\|\|\|/items/2d616949-b7b7-46f0-9692-646217b3477a, Garcia-Torres, E. (Estefania)\|\|\|/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8, Montalbán, C. (Carlos)\|\|\|/items/7c7c01be-65ba-416a-a29b-b05f212c1b27, Dodero, A. (Anna)\|\|\|/items/29078649-9179-4f2a-a305-9827711d4b27, Arranz, R. (Reyes)\|\|\|/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5, Heras, N. (Natalia) de las\|\|\|/items/f8e78df7-bc72-404d-8122-60fc2976c701, Pascual-Cascon, M.J. (Maria Jesus)\|\|\|/items/f0290602-545e-4756-b526-32b6d56ff0ae, López-Jiménez, J. (Javier)\|\|\|/items/33646694-560a-48b0-a994-709826c7ff4d, Spina, M. (Michelle)\|\|\|/items/45b7854c-ef1d-4f3c-a700-a29398e1363f, Re, A. (Alessandro)\|\|\|/items/cc3b8cee-c417-4ff9-bd9b-58990744667f, González de Villambrosía, S. (Sonia)\|\|\|/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e, Bobillo, S. (Sabella)\|\|\|/items/31e94435-1f28-46db-a819-dcdb5f89afb8, Federico, M. (Massimo)\|\|\|/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dnet:dadun_______::154565daf0ef4b4bb2d4dfc2a6329d6e
Acceso en línea:	https://hdl.handle.net/10171/124273
Access Level:	acceso abierto
Palabra clave:	Peripheral Lymphomas Autologous Transplantation Survival

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network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
title	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
spellingShingle	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study Martín-García-Sancho, A. (Alejandro)\|\|\|/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 Peripheral Lymphomas Autologous Transplantation Survival
title_short	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
title_full	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
title_fullStr	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
title_full_unstemmed	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
title_sort	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
dc.creator.none.fl_str_mv	Martín-García-Sancho, A. (Alejandro)\|\|\|/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 Bellei, M. (Monica)\|\|\|/items/066f8838-ec5c-4121-ad8f-2976d2f946a9 Lopez-Parra, M. (Miriam)\|\|\|/items/5e1bb5db-95e6-4107-ab31-89287abeb248 Gritti, G. (Giuseppe)\|\|\|/items/9978abb8-e9da-4b73-8705-3d5cec449ce9 Cortés, M. (María)\|\|\|/items/f6b827b1-1288-4db3-b09c-e762bab4203d Novelli, S. (Silvana)\|\|\|/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4 Panizo, C. (Carlos)\|\|\|/items/a5fb9193-be12-418c-9a99-929473b7bb3b Petrucci, L. (Luigi)\|\|\|/items/2d1b869f-552b-4598-b07f-632a05466b75 Gutierrez, A. (Antonio)\|\|\|/items/cd08206a-1bde-4f25-a9e4-681014c712be Dlouhy, I. (Ivan)\|\|\|/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c Bastos-Oreiro, M. (Mariana)\|\|\|/items/9798d413-d64d-4b19-b5cf-7987a1d80938 Sancho, J. M. (Juan Manuel)\|\|\|/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea Ramírez, M.J. (Maria José)\|\|\|/items/3c833d8f-d679-4602-828e-cd218813027a Moraleda, J.M. (Jose Maria)\|\|\|/items/6a96c554-773d-428a-9003-41d37bb21477 Carrillo-Cruz, E. (Estrella)\|\|\|/items/e7430696-2680-4a72-905a-4e87a3322605 Jiménez-Ubieto, A. (Ana)\|\|\|/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5 Jarque, I. (Isidro)\|\|\|/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3 Orsucci, L. (Lorella)\|\|\|/items/2d616949-b7b7-46f0-9692-646217b3477a Garcia-Torres, E. (Estefania)\|\|\|/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8 Montalbán, C. (Carlos)\|\|\|/items/7c7c01be-65ba-416a-a29b-b05f212c1b27 Dodero, A. (Anna)\|\|\|/items/29078649-9179-4f2a-a305-9827711d4b27 Arranz, R. (Reyes)\|\|\|/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5 Heras, N. (Natalia) de las\|\|\|/items/f8e78df7-bc72-404d-8122-60fc2976c701 Pascual-Cascon, M.J. (Maria Jesus)\|\|\|/items/f0290602-545e-4756-b526-32b6d56ff0ae López-Jiménez, J. (Javier)\|\|\|/items/33646694-560a-48b0-a994-709826c7ff4d Spina, M. (Michelle)\|\|\|/items/45b7854c-ef1d-4f3c-a700-a29398e1363f Re, A. (Alessandro)\|\|\|/items/cc3b8cee-c417-4ff9-bd9b-58990744667f González de Villambrosía, S. (Sonia)\|\|\|/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e Bobillo, S. (Sabella)\|\|\|/items/31e94435-1f28-46db-a819-dcdb5f89afb8 Federico, M. (Massimo)\|\|\|/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8
author	Martín-García-Sancho, A. (Alejandro)\|\|\|/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548
author_facet	Martín-García-Sancho, A. (Alejandro)\|\|\|/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 Bellei, M. (Monica)\|\|\|/items/066f8838-ec5c-4121-ad8f-2976d2f946a9 Lopez-Parra, M. (Miriam)\|\|\|/items/5e1bb5db-95e6-4107-ab31-89287abeb248 Gritti, G. (Giuseppe)\|\|\|/items/9978abb8-e9da-4b73-8705-3d5cec449ce9 Cortés, M. (María)\|\|\|/items/f6b827b1-1288-4db3-b09c-e762bab4203d Novelli, S. (Silvana)\|\|\|/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4 Panizo, C. (Carlos)\|\|\|/items/a5fb9193-be12-418c-9a99-929473b7bb3b Petrucci, L. (Luigi)\|\|\|/items/2d1b869f-552b-4598-b07f-632a05466b75 Gutierrez, A. (Antonio)\|\|\|/items/cd08206a-1bde-4f25-a9e4-681014c712be Dlouhy, I. (Ivan)\|\|\|/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c Bastos-Oreiro, M. (Mariana)\|\|\|/items/9798d413-d64d-4b19-b5cf-7987a1d80938 Sancho, J. M. (Juan Manuel)\|\|\|/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea Ramírez, M.J. (Maria José)\|\|\|/items/3c833d8f-d679-4602-828e-cd218813027a Moraleda, J.M. (Jose Maria)\|\|\|/items/6a96c554-773d-428a-9003-41d37bb21477 Carrillo-Cruz, E. (Estrella)\|\|\|/items/e7430696-2680-4a72-905a-4e87a3322605 Jiménez-Ubieto, A. (Ana)\|\|\|/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5 Jarque, I. (Isidro)\|\|\|/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3 Orsucci, L. (Lorella)\|\|\|/items/2d616949-b7b7-46f0-9692-646217b3477a Garcia-Torres, E. (Estefania)\|\|\|/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8 Montalbán, C. (Carlos)\|\|\|/items/7c7c01be-65ba-416a-a29b-b05f212c1b27 Dodero, A. (Anna)\|\|\|/items/29078649-9179-4f2a-a305-9827711d4b27 Arranz, R. (Reyes)\|\|\|/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5 Heras, N. (Natalia) de las\|\|\|/items/f8e78df7-bc72-404d-8122-60fc2976c701 Pascual-Cascon, M.J. (Maria Jesus)\|\|\|/items/f0290602-545e-4756-b526-32b6d56ff0ae López-Jiménez, J. (Javier)\|\|\|/items/33646694-560a-48b0-a994-709826c7ff4d Spina, M. (Michelle)\|\|\|/items/45b7854c-ef1d-4f3c-a700-a29398e1363f Re, A. (Alessandro)\|\|\|/items/cc3b8cee-c417-4ff9-bd9b-58990744667f González de Villambrosía, S. (Sonia)\|\|\|/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e Bobillo, S. (Sabella)\|\|\|/items/31e94435-1f28-46db-a819-dcdb5f89afb8 Federico, M. (Massimo)\|\|\|/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8
author_role	author
author2	Bellei, M. (Monica)\|\|\|/items/066f8838-ec5c-4121-ad8f-2976d2f946a9 Lopez-Parra, M. (Miriam)\|\|\|/items/5e1bb5db-95e6-4107-ab31-89287abeb248 Gritti, G. (Giuseppe)\|\|\|/items/9978abb8-e9da-4b73-8705-3d5cec449ce9 Cortés, M. (María)\|\|\|/items/f6b827b1-1288-4db3-b09c-e762bab4203d Novelli, S. (Silvana)\|\|\|/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4 Panizo, C. (Carlos)\|\|\|/items/a5fb9193-be12-418c-9a99-929473b7bb3b Petrucci, L. (Luigi)\|\|\|/items/2d1b869f-552b-4598-b07f-632a05466b75 Gutierrez, A. (Antonio)\|\|\|/items/cd08206a-1bde-4f25-a9e4-681014c712be Dlouhy, I. (Ivan)\|\|\|/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c Bastos-Oreiro, M. (Mariana)\|\|\|/items/9798d413-d64d-4b19-b5cf-7987a1d80938 Sancho, J. M. (Juan Manuel)\|\|\|/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea Ramírez, M.J. (Maria José)\|\|\|/items/3c833d8f-d679-4602-828e-cd218813027a Moraleda, J.M. (Jose Maria)\|\|\|/items/6a96c554-773d-428a-9003-41d37bb21477 Carrillo-Cruz, E. (Estrella)\|\|\|/items/e7430696-2680-4a72-905a-4e87a3322605 Jiménez-Ubieto, A. (Ana)\|\|\|/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5 Jarque, I. (Isidro)\|\|\|/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3 Orsucci, L. (Lorella)\|\|\|/items/2d616949-b7b7-46f0-9692-646217b3477a Garcia-Torres, E. (Estefania)\|\|\|/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8 Montalbán, C. (Carlos)\|\|\|/items/7c7c01be-65ba-416a-a29b-b05f212c1b27 Dodero, A. (Anna)\|\|\|/items/29078649-9179-4f2a-a305-9827711d4b27 Arranz, R. (Reyes)\|\|\|/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5 Heras, N. (Natalia) de las\|\|\|/items/f8e78df7-bc72-404d-8122-60fc2976c701 Pascual-Cascon, M.J. (Maria Jesus)\|\|\|/items/f0290602-545e-4756-b526-32b6d56ff0ae López-Jiménez, J. (Javier)\|\|\|/items/33646694-560a-48b0-a994-709826c7ff4d Spina, M. (Michelle)\|\|\|/items/45b7854c-ef1d-4f3c-a700-a29398e1363f Re, A. (Alessandro)\|\|\|/items/cc3b8cee-c417-4ff9-bd9b-58990744667f González de Villambrosía, S. (Sonia)\|\|\|/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e Bobillo, S. (Sabella)\|\|\|/items/31e94435-1f28-46db-a819-dcdb5f89afb8 Federico, M. (Massimo)\|\|\|/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Peripheral Lymphomas Autologous Transplantation Survival
topic	Peripheral Lymphomas Autologous Transplantation Survival
description	Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/124273
url	https://hdl.handle.net/10171/124273
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Ferrata Storti Foundation
publisher.none.fl_str_mv	Ferrata Storti Foundation
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
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repository.mail.fl_str_mv
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spelling	Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL studyMartín-García-Sancho, A. (Alejandro)\|\|\|/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548Bellei, M. (Monica)\|\|\|/items/066f8838-ec5c-4121-ad8f-2976d2f946a9Lopez-Parra, M. (Miriam)\|\|\|/items/5e1bb5db-95e6-4107-ab31-89287abeb248Gritti, G. (Giuseppe)\|\|\|/items/9978abb8-e9da-4b73-8705-3d5cec449ce9Cortés, M. (María)\|\|\|/items/f6b827b1-1288-4db3-b09c-e762bab4203dNovelli, S. (Silvana)\|\|\|/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4Panizo, C. (Carlos)\|\|\|/items/a5fb9193-be12-418c-9a99-929473b7bb3bPetrucci, L. (Luigi)\|\|\|/items/2d1b869f-552b-4598-b07f-632a05466b75Gutierrez, A. (Antonio)\|\|\|/items/cd08206a-1bde-4f25-a9e4-681014c712beDlouhy, I. (Ivan)\|\|\|/items/d63c50e5-0e8f-4129-8c3b-02c6f385905cBastos-Oreiro, M. (Mariana)\|\|\|/items/9798d413-d64d-4b19-b5cf-7987a1d80938Sancho, J. M. (Juan Manuel)\|\|\|/items/11e0ebcf-5625-4b2b-bd95-afd86d626beaRamírez, M.J. (Maria José)\|\|\|/items/3c833d8f-d679-4602-828e-cd218813027aMoraleda, J.M. (Jose Maria)\|\|\|/items/6a96c554-773d-428a-9003-41d37bb21477Carrillo-Cruz, E. (Estrella)\|\|\|/items/e7430696-2680-4a72-905a-4e87a3322605Jiménez-Ubieto, A. (Ana)\|\|\|/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5Jarque, I. (Isidro)\|\|\|/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3Orsucci, L. (Lorella)\|\|\|/items/2d616949-b7b7-46f0-9692-646217b3477aGarcia-Torres, E. (Estefania)\|\|\|/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8Montalbán, C. (Carlos)\|\|\|/items/7c7c01be-65ba-416a-a29b-b05f212c1b27Dodero, A. (Anna)\|\|\|/items/29078649-9179-4f2a-a305-9827711d4b27Arranz, R. (Reyes)\|\|\|/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5Heras, N. (Natalia) de las\|\|\|/items/f8e78df7-bc72-404d-8122-60fc2976c701Pascual-Cascon, M.J. (Maria Jesus)\|\|\|/items/f0290602-545e-4756-b526-32b6d56ff0aeLópez-Jiménez, J. (Javier)\|\|\|/items/33646694-560a-48b0-a994-709826c7ff4dSpina, M. (Michelle)\|\|\|/items/45b7854c-ef1d-4f3c-a700-a29398e1363fRe, A. (Alessandro)\|\|\|/items/cc3b8cee-c417-4ff9-bd9b-58990744667fGonzález de Villambrosía, S. (Sonia)\|\|\|/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130eBobillo, S. (Sabella)\|\|\|/items/31e94435-1f28-46db-a819-dcdb5f89afb8Federico, M. (Massimo)\|\|\|/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8PeripheralLymphomasAutologousTransplantationSurvivalPeripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study.Ferrata Storti FoundationDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/124273reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dnet:dadun_______::154565daf0ef4b4bb2d4dfc2a6329d6e2026-06-21T12:47:57Z
score	15,811543

Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study

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