Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice

Background & Aims: Skip inflammation of the appendiceal orifice has been described in distal UC (UC-IAO) but long-term clinical outcomes are poorly established. Our aim was to evaluate the long-term clinical outcomes of UC-IAO as compared to classic distal UC. Methods: Patients with UC-IAO were...

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Detalhes bibliográficos
Autores: Lorenzo-Zúñiga García, Vicente María, Naves, Juan E., Marín, Laura, Mañosa, Míriam, Oller, Blanca, Moreno, Vicente, Zabana, Yamile, Boix Valverde, Jaume, Cabré, Eduard, Domènech, Eugeni
Formato: artículo
Fecha de publicación:2011
País:España
Recursos:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/2679
Acesso em linha:http://hdl.handle.net/20.500.12466/2679
Access Level:acceso abierto
Palavra-chave:Ulcerative colitis
Appendiceal
Prognosis
Outcomes
Treatment
3205 Medicina Interna
3207 Patología
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oai_identifier_str oai:riucv.ucv.es:20.500.12466/2679
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spelling Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orificeLorenzo-Zúñiga García, Vicente MaríaNaves, Juan E.Marín, LauraMañosa, MíriamOller, BlancaMoreno, VicenteZabana, YamileBoix Valverde, JaumeCabré, EduardDomènech, EugeniUlcerative colitisAppendicealPrognosisOutcomesTreatment3205 Medicina Interna3207 PatologíaBackground & Aims: Skip inflammation of the appendiceal orifice has been described in distal UC (UC-IAO) but long-term clinical outcomes are poorly established. Our aim was to evaluate the long-term clinical outcomes of UC-IAO as compared to classic distal UC. Methods: Patients with UC-IAO were identified from the local IBD database. Disease outcome and therapeutic requirements during follow-up were accurately collected, and compared with a control group of patients with distal UC without periappendiceal involvement matched by disease extent (proctitis/distal), smoking habit, and date and age at diagnosis. Results: Fourteen UC patients were found to have UC-IAO, most of them with initial extent of UC limited to the rectum. All patients were initially managed with mesalazine administered orally (28.5%), topically (28.5%), or in combination (43%). After a median follow-up of 78 months (interquartile range - IQR 45-123) most UC-IAO patients were successfully managed with oral and/or topical aminosalycilates. Only one of them developed proximal disease progression. As compared to controls, no differences in clinical outcomes or therapeutic requirements were found. Conclusions: Patients with UC-IAO tend to present a mild course, with a low probability to develop proximal progression of disease extent or to require immunosuppressive therapy or colectomy.20232023-01-1220112011-12-0120112011-12-0120222022-12-17journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/2679reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/26792026-06-19T08:32:07Z
dc.title.none.fl_str_mv Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
title Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
spellingShingle Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
Lorenzo-Zúñiga García, Vicente María
Ulcerative colitis
Appendiceal
Prognosis
Outcomes
Treatment
3205 Medicina Interna
3207 Patología
title_short Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
title_full Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
title_fullStr Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
title_full_unstemmed Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
title_sort Long-term outcome of patients wih distal ulcerative colitis and inflammation of the appendiceal orifice
dc.creator.none.fl_str_mv Lorenzo-Zúñiga García, Vicente María
Naves, Juan E.
Marín, Laura
Mañosa, Míriam
Oller, Blanca
Moreno, Vicente
Zabana, Yamile
Boix Valverde, Jaume
Cabré, Eduard
Domènech, Eugeni
author Lorenzo-Zúñiga García, Vicente María
author_facet Lorenzo-Zúñiga García, Vicente María
Naves, Juan E.
Marín, Laura
Mañosa, Míriam
Oller, Blanca
Moreno, Vicente
Zabana, Yamile
Boix Valverde, Jaume
Cabré, Eduard
Domènech, Eugeni
author_role author
author2 Naves, Juan E.
Marín, Laura
Mañosa, Míriam
Oller, Blanca
Moreno, Vicente
Zabana, Yamile
Boix Valverde, Jaume
Cabré, Eduard
Domènech, Eugeni
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Ulcerative colitis
Appendiceal
Prognosis
Outcomes
Treatment
3205 Medicina Interna
3207 Patología
topic Ulcerative colitis
Appendiceal
Prognosis
Outcomes
Treatment
3205 Medicina Interna
3207 Patología
description Background & Aims: Skip inflammation of the appendiceal orifice has been described in distal UC (UC-IAO) but long-term clinical outcomes are poorly established. Our aim was to evaluate the long-term clinical outcomes of UC-IAO as compared to classic distal UC. Methods: Patients with UC-IAO were identified from the local IBD database. Disease outcome and therapeutic requirements during follow-up were accurately collected, and compared with a control group of patients with distal UC without periappendiceal involvement matched by disease extent (proctitis/distal), smoking habit, and date and age at diagnosis. Results: Fourteen UC patients were found to have UC-IAO, most of them with initial extent of UC limited to the rectum. All patients were initially managed with mesalazine administered orally (28.5%), topically (28.5%), or in combination (43%). After a median follow-up of 78 months (interquartile range - IQR 45-123) most UC-IAO patients were successfully managed with oral and/or topical aminosalycilates. Only one of them developed proximal disease progression. As compared to controls, no differences in clinical outcomes or therapeutic requirements were found. Conclusions: Patients with UC-IAO tend to present a mild course, with a low probability to develop proximal progression of disease extent or to require immunosuppressive therapy or colectomy.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-12-01
2011
2011-12-01
2022
2022-12-17
2023
2023-01-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/2679
url http://hdl.handle.net/20.500.12466/2679
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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