GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits controls the excitability of mouse adult cortical and amygdalar circuits via an unusual signaling mechanism involving the forma...

Descripción completa

Detalles Bibliográficos
Autores: Bossi, Simon, Dhanasobhon, Dhanasak, Ellis-Davies, Graham C.R., Frontera, Jimena, Brito Van Velze, Marcel de, Lourenço, Joana, Murillo, Alvaro, Luján, Rafael, Casado, Mariano, Pérez-Otaño, Isabel, Bacci, Alberto, Popa, Daniela, Paolitti, Pierre, Rebola, Nelson
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/306769
Acceso en línea:http://hdl.handle.net/10261/306769
Access Level:acceso abierto
Palabra clave:Neurotransmission
Receptors
NMDA
GluN3A
Glycine
Interneuron
Somatostatin interneurons
Fear
Cortex
Amygdala
Descripción
Sumario:GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits controls the excitability of mouse adult cortical and amygdalar circuits via an unusual signaling mechanism involving the formation of excitatory glycine GluN1/GluN3A receptors (eGlyRs) and their tonic activation by extracellular glycine. eGlyRs are mostly extrasynaptic and reside in specific neuronal populations, including the principal cells of the basolateral amygdala (BLA) and SST-positive interneurons (SST-INs) of the neocortex. In the BLA, tonic eGlyR currents are sensitive to fear-conditioning protocols, are subject to neuromodulation by the dopaminergic system, and control the stability of fear memories. In the neocortex, eGlyRs control the in vivo spiking of SST-INs and the behavior-dependent modulation of cortical activity. GluN3A-containing eGlyRs thus represent a novel and widespread signaling modality in the adult brain, with attributes that strikingly depart from those of conventional NMDARs.

Similares en LA Referencia