Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism

Although current guidelines recommend standard cardiopulmonary exercise testing (CPET) to evaluate symptomatic patients after pulmonary embolism (PE), CPET with simultaneous echocardiography could provide relevant information to evaluate right ventricular–pulmonary arterial coupling. The aim of this...

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Autores: Khilzi, Karys, Rodríguez Chiaradia, Diego Agustín, Piccari, Lucilla, Franco, Gerard, Rodó Pin, Anna, Herranz Blasco, Ana, Blanco Vich, Isabel, Paciocco, Giuseppe, Volpiano, Lorenzo, González García, Jose, Diez Llaneza, Ana, Molina, Lluis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/224526
Acceso en línea:https://hdl.handle.net/2445/224526
Access Level:acceso abierto
Palabra clave:Embòlia pulmonar
Exercici
Ecocardiografia
Pulmonary embolism
Exercise
Echocardiography
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spelling Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary EmbolismKhilzi, KarysRodríguez Chiaradia, Diego AgustínPiccari, LucillaFranco, GerardRodó Pin, AnnaHerranz Blasco, AnaBlanco Vich, IsabelPaciocco, GiuseppeVolpiano, LorenzoGonzález García, JoseDiez Llaneza, AnaMolina, LluisEmbòlia pulmonarExerciciEcocardiografiaPulmonary embolismExerciseEchocardiographyAlthough current guidelines recommend standard cardiopulmonary exercise testing (CPET) to evaluate symptomatic patients after pulmonary embolism (PE), CPET with simultaneous echocardiography could provide relevant information to evaluate right ventricular–pulmonary arterial coupling. The aim of this study was to investigate exercise‐induced changes in echocardiographic variables of RV function or RV– arterial coupling in patients with residual thrombotic defects at 3 months after PE. This retrospective study investigated patients with residual thromboembolic disease on V/Q scintigraphy with persistent symptoms despite adequate anticoagulation after 3 months of acute PE, and resting echocardiography with a low probability of PH. At rest and during exercise, CPET and doppler echocardiography were performed following a standard protocol. Forty‐five patients were included, completing a follow‐up period of at least 24 months. The mean (standard deviation) age was 63 (15) years, and 24 (53%) patients were male. Four patients developed CTEPH after 2 years follow up. Correlation analyses showed that the peak TAPSE was significantly associated with peak workload (r=0.454, p =0.003), peak VO2 (r=0.558, p<0.001), VE/VECO2 (AT) (r=−0.531, p < 0.001), and oxygen pulse (r=0.375, p = 0.02). TAPSE/PASP was only slightly associated with peak workload (r =0.300, p = 0.045). By contrast, the change on TAPSE (from rest to peak) was significantly correlate with peak oxygen uptake (r =0.491, p=0.01). Also, reduced VO2 at AT and TAPSE/PASP was seen in patients with CTEPH. CPET with synchronic echocardiography could be a useful tool in early assessment of symptomatic patients with perfusion defects on imaging after 3 months of correctly treated PE.The University of Chicago Press2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/224526Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/pul2.70045Pulmonary Circulation, 2025, vol. 15, num.1, p. e70045https://doi.org/10.1002/pul2.70045cc-by-nc (c) Khilzi, Karys et al. , 2025info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2245262026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
title Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
spellingShingle Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
Khilzi, Karys
Embòlia pulmonar
Exercici
Ecocardiografia
Pulmonary embolism
Exercise
Echocardiography
title_short Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
title_full Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
title_fullStr Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
title_full_unstemmed Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
title_sort Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
dc.creator.none.fl_str_mv Khilzi, Karys
Rodríguez Chiaradia, Diego Agustín
Piccari, Lucilla
Franco, Gerard
Rodó Pin, Anna
Herranz Blasco, Ana
Blanco Vich, Isabel
Paciocco, Giuseppe
Volpiano, Lorenzo
González García, Jose
Diez Llaneza, Ana
Molina, Lluis
author Khilzi, Karys
author_facet Khilzi, Karys
Rodríguez Chiaradia, Diego Agustín
Piccari, Lucilla
Franco, Gerard
Rodó Pin, Anna
Herranz Blasco, Ana
Blanco Vich, Isabel
Paciocco, Giuseppe
Volpiano, Lorenzo
González García, Jose
Diez Llaneza, Ana
Molina, Lluis
author_role author
author2 Rodríguez Chiaradia, Diego Agustín
Piccari, Lucilla
Franco, Gerard
Rodó Pin, Anna
Herranz Blasco, Ana
Blanco Vich, Isabel
Paciocco, Giuseppe
Volpiano, Lorenzo
González García, Jose
Diez Llaneza, Ana
Molina, Lluis
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embòlia pulmonar
Exercici
Ecocardiografia
Pulmonary embolism
Exercise
Echocardiography
topic Embòlia pulmonar
Exercici
Ecocardiografia
Pulmonary embolism
Exercise
Echocardiography
description Although current guidelines recommend standard cardiopulmonary exercise testing (CPET) to evaluate symptomatic patients after pulmonary embolism (PE), CPET with simultaneous echocardiography could provide relevant information to evaluate right ventricular–pulmonary arterial coupling. The aim of this study was to investigate exercise‐induced changes in echocardiographic variables of RV function or RV– arterial coupling in patients with residual thrombotic defects at 3 months after PE. This retrospective study investigated patients with residual thromboembolic disease on V/Q scintigraphy with persistent symptoms despite adequate anticoagulation after 3 months of acute PE, and resting echocardiography with a low probability of PH. At rest and during exercise, CPET and doppler echocardiography were performed following a standard protocol. Forty‐five patients were included, completing a follow‐up period of at least 24 months. The mean (standard deviation) age was 63 (15) years, and 24 (53%) patients were male. Four patients developed CTEPH after 2 years follow up. Correlation analyses showed that the peak TAPSE was significantly associated with peak workload (r=0.454, p =0.003), peak VO2 (r=0.558, p<0.001), VE/VECO2 (AT) (r=−0.531, p < 0.001), and oxygen pulse (r=0.375, p = 0.02). TAPSE/PASP was only slightly associated with peak workload (r =0.300, p = 0.045). By contrast, the change on TAPSE (from rest to peak) was significantly correlate with peak oxygen uptake (r =0.491, p=0.01). Also, reduced VO2 at AT and TAPSE/PASP was seen in patients with CTEPH. CPET with synchronic echocardiography could be a useful tool in early assessment of symptomatic patients with perfusion defects on imaging after 3 months of correctly treated PE.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/224526
url https://hdl.handle.net/2445/224526
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/pul2.70045
Pulmonary Circulation, 2025, vol. 15, num.1, p. e70045
https://doi.org/10.1002/pul2.70045
dc.rights.none.fl_str_mv cc-by-nc (c) Khilzi, Karys et al. , 2025
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Khilzi, Karys et al. , 2025
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The University of Chicago Press
publisher.none.fl_str_mv The University of Chicago Press
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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