Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications

PURPOSE: In ST-segment elevation myocardial infarction (STEMI) patients, longitudinal strain (LS) in remote non-infarcted myocardium (RNM) has not yet been characterized by tissue tracking (TT) cardiovascular magnetic resonance (CMR). In STEMI patients, we aimed to characterize RNM-LS by TT-CMR and...

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Autores: Gavara, Jose, Rodriguez-Palomares, Jose F, Rios-Navarro, Cesar, Valente, Filipa, Monmeneu, Jose V, Lopez-Lereu, Maria P, Ferreira-Gonzalez, Ignacio, Garcia Del Blanco, Bruno, Otaegui, Imanol, Canoves, Joaquim, de Dios, Elena, Perez, Nerea, Racugno, Paolo, Bonanad, Clara, Minana, Gema, Marcos, Victor, Barrabes, Jose A, Evangelista, Arturo, Moratal, David, Bayes-Genis, Antoni, Nunez, Julio, Chorro, Francisco J, Bodi, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p4533
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/4533
Access Level:acceso abierto
Palabra clave:Cardiovascular magnetic resonance
Myocardial infarction
Prognosis
Strain
Tissue tracking
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spelling Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implicationsGavara, JoseRodriguez-Palomares, Jose FRios-Navarro, CesarValente, FilipaMonmeneu, Jose VLopez-Lereu, Maria PFerreira-Gonzalez, IgnacioGarcia Del Blanco, BrunoOtaegui, ImanolCanoves, Joaquimde Dios, ElenaPerez, NereaRacugno, PaoloBonanad, ClaraMinana, GemaMarcos, VictorBarrabes, Jose AEvangelista, ArturoMoratal, DavidBayes-Genis, AntoniNunez, JulioChorro, Francisco JBodi, VicenteCardiovascular magnetic resonanceMyocardial infarctionPrognosisStrainTissue trackingPURPOSE: In ST-segment elevation myocardial infarction (STEMI) patients, longitudinal strain (LS) in remote non-infarcted myocardium (RNM) has not yet been characterized by tissue tracking (TT) cardiovascular magnetic resonance (CMR). In STEMI patients, we aimed to characterize RNM-LS by TT-CMR and to assess both its dynamics and its structural and prognostic implications. METHODS: We recruited 271 patients with a first STEMI studied with TT-CMR 1 week after infarction. Of these patients, 145 underwent 1-week and 6-month TT-CMR and were used to characterize both the dynamics and the short-term and long-term structural implications of RNM-LS. Based on previously validated data, RNM areas were defined depending on the culprit coronary artery. RESULTS: Reduced RNM-LS at 1 week (n = 70, 48%) was associated with larger infarct size and more depressed left ventricular ejection fraction (LVEF) at both the 1-week and 6-month TT-CMR (p value < 0.001). Late normalization of RNM-LS was frequent (28/70, 40%) and independently related to late recovery of LVEF (p value = 0.002). Patients with reduced RNM-LS at 1-week TT-CMR had more major adverse cardiac events (death, heart failure or re-infarction) in both the 271 patients included in the study group (26% vs. 11%, p value = 0.002) and in an external validation cohort made up of 177 STEMI patients (57% vs. 13%, p value < 0.001). CONCLUSION: After STEMI, reduced RNM-LS by TT-CMR is common and is associated with more severe short- and long-term structural damage. There is a beneficial tendency towards recovery of RNM-LS that parallels late recovery of LVEF. More events occur in patients with reduced RNM-LS.SPRINGER2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/4533INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGINGISSN: 15695794ISSNe: 18758312reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p45332026-06-07T16:35:31Z
dc.title.none.fl_str_mv Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
title Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
spellingShingle Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
Gavara, Jose
Cardiovascular magnetic resonance
Myocardial infarction
Prognosis
Strain
Tissue tracking
title_short Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
title_full Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
title_fullStr Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
title_full_unstemmed Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
title_sort Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications
dc.creator.none.fl_str_mv Gavara, Jose
Rodriguez-Palomares, Jose F
Rios-Navarro, Cesar
Valente, Filipa
Monmeneu, Jose V
Lopez-Lereu, Maria P
Ferreira-Gonzalez, Ignacio
Garcia Del Blanco, Bruno
Otaegui, Imanol
Canoves, Joaquim
de Dios, Elena
Perez, Nerea
Racugno, Paolo
Bonanad, Clara
Minana, Gema
Marcos, Victor
Barrabes, Jose A
Evangelista, Arturo
Moratal, David
Bayes-Genis, Antoni
Nunez, Julio
Chorro, Francisco J
Bodi, Vicente
author Gavara, Jose
author_facet Gavara, Jose
Rodriguez-Palomares, Jose F
Rios-Navarro, Cesar
Valente, Filipa
Monmeneu, Jose V
Lopez-Lereu, Maria P
Ferreira-Gonzalez, Ignacio
Garcia Del Blanco, Bruno
Otaegui, Imanol
Canoves, Joaquim
de Dios, Elena
Perez, Nerea
Racugno, Paolo
Bonanad, Clara
Minana, Gema
Marcos, Victor
Barrabes, Jose A
Evangelista, Arturo
Moratal, David
Bayes-Genis, Antoni
Nunez, Julio
Chorro, Francisco J
Bodi, Vicente
author_role author
author2 Rodriguez-Palomares, Jose F
Rios-Navarro, Cesar
Valente, Filipa
Monmeneu, Jose V
Lopez-Lereu, Maria P
Ferreira-Gonzalez, Ignacio
Garcia Del Blanco, Bruno
Otaegui, Imanol
Canoves, Joaquim
de Dios, Elena
Perez, Nerea
Racugno, Paolo
Bonanad, Clara
Minana, Gema
Marcos, Victor
Barrabes, Jose A
Evangelista, Arturo
Moratal, David
Bayes-Genis, Antoni
Nunez, Julio
Chorro, Francisco J
Bodi, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cardiovascular magnetic resonance
Myocardial infarction
Prognosis
Strain
Tissue tracking
topic Cardiovascular magnetic resonance
Myocardial infarction
Prognosis
Strain
Tissue tracking
description PURPOSE: In ST-segment elevation myocardial infarction (STEMI) patients, longitudinal strain (LS) in remote non-infarcted myocardium (RNM) has not yet been characterized by tissue tracking (TT) cardiovascular magnetic resonance (CMR). In STEMI patients, we aimed to characterize RNM-LS by TT-CMR and to assess both its dynamics and its structural and prognostic implications. METHODS: We recruited 271 patients with a first STEMI studied with TT-CMR 1 week after infarction. Of these patients, 145 underwent 1-week and 6-month TT-CMR and were used to characterize both the dynamics and the short-term and long-term structural implications of RNM-LS. Based on previously validated data, RNM areas were defined depending on the culprit coronary artery. RESULTS: Reduced RNM-LS at 1 week (n = 70, 48%) was associated with larger infarct size and more depressed left ventricular ejection fraction (LVEF) at both the 1-week and 6-month TT-CMR (p value < 0.001). Late normalization of RNM-LS was frequent (28/70, 40%) and independently related to late recovery of LVEF (p value = 0.002). Patients with reduced RNM-LS at 1-week TT-CMR had more major adverse cardiac events (death, heart failure or re-infarction) in both the 271 patients included in the study group (26% vs. 11%, p value = 0.002) and in an external validation cohort made up of 177 STEMI patients (57% vs. 13%, p value < 0.001). CONCLUSION: After STEMI, reduced RNM-LS by TT-CMR is common and is associated with more severe short- and long-term structural damage. There is a beneficial tendency towards recovery of RNM-LS that parallels late recovery of LVEF. More events occur in patients with reduced RNM-LS.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/4533
url https://incliva.portalinvestigacion.com/publicaciones/4533
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
ISSN: 15695794
ISSNe: 18758312
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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