A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties

A series of novel azonia aromatic heterocycles formed by a pyridazinobenzimidazolium system has been synthesized. Spectrofluorimetric and circular dichroism measurements, as well as theoretical simulations for these materials, have shown their interesting fluorescence properties and DNA-binding abil...

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Autores: Bosch Mendoza, Pedro Emilio, Marcelo Alejandre, Gema|||0000-0003-4955-7400, Matamoros Recio, Alejandra, Sucunza Sáenz, David|||0000-0002-3307-4204, Mendicuti Madrid, Francisco Enrique Javier|||0000-0001-7930-2703, Domingo Galán, Alberto|||0000-0002-4332-7033, Vaquero López, Juan José|||0000-0002-3820-9673
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/64166
Acceso en línea:http://hdl.handle.net/10017/64166
https://dx.doi.org/10.1016/j.dyepig.2021.109443
Access Level:acceso abierto
Palabra clave:Pyridazinobenzimidazolium cation
DNA binding
Cell staining
Azonia aromatic heterocycles
Química
Chemistry
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spelling A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding propertiesBosch Mendoza, Pedro EmilioMarcelo Alejandre, Gema|||0000-0003-4955-7400Matamoros Recio, AlejandraSucunza Sáenz, David|||0000-0002-3307-4204Mendicuti Madrid, Francisco Enrique Javier|||0000-0001-7930-2703Domingo Galán, Alberto|||0000-0002-4332-7033Vaquero López, Juan José|||0000-0002-3820-9673Pyridazinobenzimidazolium cationDNA bindingCell stainingAzonia aromatic heterocyclesQuímicaChemistryA series of novel azonia aromatic heterocycles formed by a pyridazinobenzimidazolium system has been synthesized. Spectrofluorimetric and circular dichroism measurements, as well as theoretical simulations for these materials, have shown their interesting fluorescence properties and DNA-binding ability. Stoichiometries and binding constants were obtained by fluorescence and the induced circular dichroism spectra analysis. Moreover, the potential of these compounds for cell staining has been investigated in living HeLa cells by confocal microscopy imaging.20212021-05-13journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/64166https://dx.doi.org/10.1016/j.dyepig.2021.109443reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/641662026-06-18T11:13:07Z
dc.title.none.fl_str_mv A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
title A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
spellingShingle A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
Bosch Mendoza, Pedro Emilio
Pyridazinobenzimidazolium cation
DNA binding
Cell staining
Azonia aromatic heterocycles
Química
Chemistry
title_short A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
title_full A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
title_fullStr A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
title_full_unstemmed A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
title_sort A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties
dc.creator.none.fl_str_mv Bosch Mendoza, Pedro Emilio
Marcelo Alejandre, Gema|||0000-0003-4955-7400
Matamoros Recio, Alejandra
Sucunza Sáenz, David|||0000-0002-3307-4204
Mendicuti Madrid, Francisco Enrique Javier|||0000-0001-7930-2703
Domingo Galán, Alberto|||0000-0002-4332-7033
Vaquero López, Juan José|||0000-0002-3820-9673
author Bosch Mendoza, Pedro Emilio
author_facet Bosch Mendoza, Pedro Emilio
Marcelo Alejandre, Gema|||0000-0003-4955-7400
Matamoros Recio, Alejandra
Sucunza Sáenz, David|||0000-0002-3307-4204
Mendicuti Madrid, Francisco Enrique Javier|||0000-0001-7930-2703
Domingo Galán, Alberto|||0000-0002-4332-7033
Vaquero López, Juan José|||0000-0002-3820-9673
author_role author
author2 Marcelo Alejandre, Gema|||0000-0003-4955-7400
Matamoros Recio, Alejandra
Sucunza Sáenz, David|||0000-0002-3307-4204
Mendicuti Madrid, Francisco Enrique Javier|||0000-0001-7930-2703
Domingo Galán, Alberto|||0000-0002-4332-7033
Vaquero López, Juan José|||0000-0002-3820-9673
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Pyridazinobenzimidazolium cation
DNA binding
Cell staining
Azonia aromatic heterocycles
Química
Chemistry
topic Pyridazinobenzimidazolium cation
DNA binding
Cell staining
Azonia aromatic heterocycles
Química
Chemistry
description A series of novel azonia aromatic heterocycles formed by a pyridazinobenzimidazolium system has been synthesized. Spectrofluorimetric and circular dichroism measurements, as well as theoretical simulations for these materials, have shown their interesting fluorescence properties and DNA-binding ability. Stoichiometries and binding constants were obtained by fluorescence and the induced circular dichroism spectra analysis. Moreover, the potential of these compounds for cell staining has been investigated in living HeLa cells by confocal microscopy imaging.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-05-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/64166
https://dx.doi.org/10.1016/j.dyepig.2021.109443
url http://hdl.handle.net/10017/64166
https://dx.doi.org/10.1016/j.dyepig.2021.109443
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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