Mutations in non-tumoral human urothelium: disease prelude or epilogue?

Bladder cancer is characterized by high rates of recurrence and multifocality, features which have commonly been associated with the colonization of widespread areas of non-neoplastic urothelium by mutant cells, a phenomenon known as field change. Whether mutant fields in the bladder arise from tumo...

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Detalles Bibliográficos
Autores: Piedrafita, Gabriel, Fernández, Luis, Real, Francisco X.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/46056
Acceso en línea:http://hdl.handle.net/10230/46056
http://dx.doi.org/10.3233/BLC-200363
Access Level:acceso abierto
Palabra clave:Field cancerization
Bladder cancer
Deep sequencing
Preneoplasia
Somatic evolution
Clonal evolution
Urothelium
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spelling Mutations in non-tumoral human urothelium: disease prelude or epilogue?Piedrafita, GabrielFernández, LuisReal, Francisco X.Field cancerizationBladder cancerDeep sequencingPreneoplasiaSomatic evolutionClonal evolutionUrotheliumBladder cancer is characterized by high rates of recurrence and multifocality, features which have commonly been associated with the colonization of widespread areas of non-neoplastic urothelium by mutant cells, a phenomenon known as field change. Whether mutant fields in the bladder arise from tumor cells or develop from the accumulation of somatic mutations followed by clonal expansions of non-transformed progenitor cells during lifetime remains unanswered. In this issue, Strandgaard et al. perform a deep-sequencing analysis of paired samples of tumor and histologically normal-appearing urothelium from four patients with advanced bladder cancer. By using a careful validation process, they report several mutations exclusive of normal, non-neoplastic tissue, suggesting that multiple fields precede (or develop independently from) the disease. Here, we discuss the main results from this work and elaborate on the biological implications and open questions in the context of normal somatic clonal evolution and cancer risk. We finish providing some general guidelines for future experiments to resolve the role of field changes in bladder carcinogenesis and its possible clinical relevance.IOS Press202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/46056http://dx.doi.org/10.3233/BLC-200363reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBladder Cancer. 2020; 6(3):249-52© 2020 – IOS Press and the authors. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/460562026-05-29T05:05:01Z
dc.title.none.fl_str_mv Mutations in non-tumoral human urothelium: disease prelude or epilogue?
title Mutations in non-tumoral human urothelium: disease prelude or epilogue?
spellingShingle Mutations in non-tumoral human urothelium: disease prelude or epilogue?
Piedrafita, Gabriel
Field cancerization
Bladder cancer
Deep sequencing
Preneoplasia
Somatic evolution
Clonal evolution
Urothelium
title_short Mutations in non-tumoral human urothelium: disease prelude or epilogue?
title_full Mutations in non-tumoral human urothelium: disease prelude or epilogue?
title_fullStr Mutations in non-tumoral human urothelium: disease prelude or epilogue?
title_full_unstemmed Mutations in non-tumoral human urothelium: disease prelude or epilogue?
title_sort Mutations in non-tumoral human urothelium: disease prelude or epilogue?
dc.creator.none.fl_str_mv Piedrafita, Gabriel
Fernández, Luis
Real, Francisco X.
author Piedrafita, Gabriel
author_facet Piedrafita, Gabriel
Fernández, Luis
Real, Francisco X.
author_role author
author2 Fernández, Luis
Real, Francisco X.
author2_role author
author
dc.subject.none.fl_str_mv Field cancerization
Bladder cancer
Deep sequencing
Preneoplasia
Somatic evolution
Clonal evolution
Urothelium
topic Field cancerization
Bladder cancer
Deep sequencing
Preneoplasia
Somatic evolution
Clonal evolution
Urothelium
description Bladder cancer is characterized by high rates of recurrence and multifocality, features which have commonly been associated with the colonization of widespread areas of non-neoplastic urothelium by mutant cells, a phenomenon known as field change. Whether mutant fields in the bladder arise from tumor cells or develop from the accumulation of somatic mutations followed by clonal expansions of non-transformed progenitor cells during lifetime remains unanswered. In this issue, Strandgaard et al. perform a deep-sequencing analysis of paired samples of tumor and histologically normal-appearing urothelium from four patients with advanced bladder cancer. By using a careful validation process, they report several mutations exclusive of normal, non-neoplastic tissue, suggesting that multiple fields precede (or develop independently from) the disease. Here, we discuss the main results from this work and elaborate on the biological implications and open questions in the context of normal somatic clonal evolution and cancer risk. We finish providing some general guidelines for future experiments to resolve the role of field changes in bladder carcinogenesis and its possible clinical relevance.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/46056
http://dx.doi.org/10.3233/BLC-200363
url http://hdl.handle.net/10230/46056
http://dx.doi.org/10.3233/BLC-200363
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Bladder Cancer. 2020; 6(3):249-52
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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