Association between the Planetary Health Diet Index and growth differentiation factor-15: the Seniors ENRICA-2 cohort
The growth differentiation factor-15 (GDF-15) is an inflammaging biomarker, predictor of cardiovascular disease (CVD), and several other non-communicable diseases (NCD) that represent the main causes of death globally, for which prevention is essential. Current worldwide threats include NCD and envi...
| Authors: | , , , , , |
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| Format: | article |
| Publication Date: | 2025 |
| Country: | España |
| Institution: | Universidad Autónoma de Madrid |
| Repository: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Language: | English |
| OAI Identifier: | oai:repositorio.uam.es:10486/720049 |
| Online Access: | http://hdl.handle.net/10486/720049 https://dx.doi.org/10.1007/s11357-025-01712-8 |
| Access Level: | Open access |
| Keyword: | Planetary health diet Plant-based diets Cardiovascular disease Infammaging biomarkers Epidemiology Medicina |
| Summary: | The growth differentiation factor-15 (GDF-15) is an inflammaging biomarker, predictor of cardiovascular disease (CVD), and several other non-communicable diseases (NCD) that represent the main causes of death globally, for which prevention is essential. Current worldwide threats include NCD and environmental burden, where diet is a key determinant. Therefore, the EAT-Lancet Commission developed the Planetary Health Diet Index (PHDI), a dietary pattern designed to ameliorate human and environmental health. The objective of the study was to evaluate the association between the PHDI and serum concentrations of GDF-15 in older adults. Study participants were 2497 people aged+65 years from the Seniors-ENRICA-2 study. Food consumption was obtained through a validated diet history, and adherence to the PHDI was estimated with a score of 15 food groups (range 0–140), where higher scores indicated better adherence. Analyses for the association between the PHDI and GDF-15 concentrations were performed using multivariable linear regression models, adjusting for main potential confounders. The PHDI showed an inverse dose– response association with GDF-15 concentrations. Compared with participants in the lowest quartile of the PHDI, those in the highest quartile had a mean percentage difference (95% CI) of−6.8% (−11.1,−2.4) in GDF-15 concentrations. The mean percentage difference (95% CI) per 20-point increase of adherence was−4.4% (−7.7,−0.9). Consumption of whole grains, fruits, nuts, and a low intake of trans and saturated fat were important drivers of this association. Results remained robust after adjustment for other inflammation (interleukin 6), renal and cardiac (creatinine, NT-proBNP, cardiac troponin T) biomarkers, and after excluding participants with CVD, type 2 diabetes, and obesity. The PHDI was associated with lower concentrations of GDF-15. Adopting the PHDI may be a useful approach to reduce chronic inflammation and target NCD prevention in the older adult population, while staying within planetary boundaries |
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