Quorum sensing and oral biofilm: an alternative for the prevention and treatment of oral diseases
The present thesis investigates the potential of inhibiting bacterial cell-cell communication, quorum sensing (QS), to modulate oral biofilm formation. The thesis evaluates the effect of a quorum quenching (QQ) enzyme that degrades N-acylhomoserine lactones, the QS signals of gram-negative bacteria,...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/30338 |
| Acceso en línea: | http://hdl.handle.net/10347/30338 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias::Investigación::24 Ciencias de la vida::2414 Microbiología::241408 Procesos microbianos Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320103 Microbiología clínica Materias::Investigación::24 Ciencias de la vida::2415 Biología molecular::241501 Biología molecular de microorganismos |
| Sumario: | The present thesis investigates the potential of inhibiting bacterial cell-cell communication, quorum sensing (QS), to modulate oral biofilm formation. The thesis evaluates the effect of a quorum quenching (QQ) enzyme that degrades N-acylhomoserine lactones, the QS signals of gram-negative bacteria, on in vitro polymicrobial oral biofilms. The potential interactions between AHLs and a gram-positive representative, Enterococcus faecalis, were also investigated. The results presented here support the translation of QQ strategies to in vivo trials for the modulation of oral biofilms. In addition, a more intricate role of AHLs on oral biofilm formation and interactions with gram-positive bacteria is proposed. |
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