Antimicrobial peptides in the global microbiome
Antimicrobial peptides are a promising new class of antimicrobials that could address the antibiotic resistance crisis, which poses a major threat to human health. These peptides are present in all kingdoms of life, but especially in microorganisms, having multiple origins in diverse taxa. To date,...
| Autores: | , , , , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglês |
| OAI Identifier: | oai:ddd.uab.cat:284315 |
| Acesso em linha: | https://ddd.uab.cat/record/284315 https://dx.doi.org/urn:doi:10.1021/acs.est.3c01664 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Antibiotic Antimicrobial peptide Resistance Metagenome-assembled genomes Health risk Biosynthesis |
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Antimicrobial peptides in the global microbiomebiosynthetic genes and resistance determinantsChen, BingfengZhang, ZhenyanZhang, QiXu, Nuohan XuLu, Tao|||0000-0002-2030-3813Wang, TingzhangHong, WenjieFu, Zhengwei|||0000-0003-3351-3075Peñuelas, Josep|||0000-0002-7215-0150AntibioticAntimicrobial peptideResistanceMetagenome-assembled genomesHealth riskBiosynthesisAntimicrobial peptides are a promising new class of antimicrobials that could address the antibiotic resistance crisis, which poses a major threat to human health. These peptides are present in all kingdoms of life, but especially in microorganisms, having multiple origins in diverse taxa. To date, there has been no global study on the diversity of antimicrobial peptides, the hosts in which these occur, and the potential for resistance to these agents. Here, we investigated the diversity and number of antimicrobial peptides in four main habitats (aquatic, terrestrial, human, and engineered) by analyzing 52,515 metagenome-assembled genomes. The number of antimicrobial peptides was higher in the human gut microbiome than in other habitats, and most hosts of antimicrobial peptides were habitat-specific. The relative abundance of genes that confer resistance to antimicrobial peptides varied between habitats and was generally low, except for the built environment and on human skin. The horizontal transfer of potential resistance genes among these habitats was probably constrained by ecological barriers. We systematically quantified the risk of each resistance determinant to human health and found that nearly half of them pose a threat, especially those that confer resistance to multiple AMPs and polymyxin B. Our results help identify the biosynthetic potential of antimicrobial peptides in the global microbiome, further identifying peptides with a low risk of developing resistance. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/284315https://dx.doi.org/urn:doi:10.1021/acs.est.3c01664reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 TED2021-132627B-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-110521GB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1005open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2843152026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Antimicrobial peptides in the global microbiome biosynthetic genes and resistance determinants |
| title |
Antimicrobial peptides in the global microbiome |
| spellingShingle |
Antimicrobial peptides in the global microbiome Chen, Bingfeng Antibiotic Antimicrobial peptide Resistance Metagenome-assembled genomes Health risk Biosynthesis |
| title_short |
Antimicrobial peptides in the global microbiome |
| title_full |
Antimicrobial peptides in the global microbiome |
| title_fullStr |
Antimicrobial peptides in the global microbiome |
| title_full_unstemmed |
Antimicrobial peptides in the global microbiome |
| title_sort |
Antimicrobial peptides in the global microbiome |
| dc.creator.none.fl_str_mv |
Chen, Bingfeng Zhang, Zhenyan Zhang, Qi Xu, Nuohan Xu Lu, Tao|||0000-0002-2030-3813 Wang, Tingzhang Hong, Wenjie Fu, Zhengwei|||0000-0003-3351-3075 Peñuelas, Josep|||0000-0002-7215-0150 |
| author |
Chen, Bingfeng |
| author_facet |
Chen, Bingfeng Zhang, Zhenyan Zhang, Qi Xu, Nuohan Xu Lu, Tao|||0000-0002-2030-3813 Wang, Tingzhang Hong, Wenjie Fu, Zhengwei|||0000-0003-3351-3075 Peñuelas, Josep|||0000-0002-7215-0150 |
| author_role |
author |
| author2 |
Zhang, Zhenyan Zhang, Qi Xu, Nuohan Xu Lu, Tao|||0000-0002-2030-3813 Wang, Tingzhang Hong, Wenjie Fu, Zhengwei|||0000-0003-3351-3075 Peñuelas, Josep|||0000-0002-7215-0150 |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Antibiotic Antimicrobial peptide Resistance Metagenome-assembled genomes Health risk Biosynthesis |
| topic |
Antibiotic Antimicrobial peptide Resistance Metagenome-assembled genomes Health risk Biosynthesis |
| description |
Antimicrobial peptides are a promising new class of antimicrobials that could address the antibiotic resistance crisis, which poses a major threat to human health. These peptides are present in all kingdoms of life, but especially in microorganisms, having multiple origins in diverse taxa. To date, there has been no global study on the diversity of antimicrobial peptides, the hosts in which these occur, and the potential for resistance to these agents. Here, we investigated the diversity and number of antimicrobial peptides in four main habitats (aquatic, terrestrial, human, and engineered) by analyzing 52,515 metagenome-assembled genomes. The number of antimicrobial peptides was higher in the human gut microbiome than in other habitats, and most hosts of antimicrobial peptides were habitat-specific. The relative abundance of genes that confer resistance to antimicrobial peptides varied between habitats and was generally low, except for the built environment and on human skin. The horizontal transfer of potential resistance genes among these habitats was probably constrained by ecological barriers. We systematically quantified the risk of each resistance determinant to human health and found that nearly half of them pose a threat, especially those that confer resistance to multiple AMPs and polymyxin B. Our results help identify the biosynthetic potential of antimicrobial peptides in the global microbiome, further identifying peptides with a low risk of developing resistance. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/284315 https://dx.doi.org/urn:doi:10.1021/acs.est.3c01664 |
| url |
https://ddd.uab.cat/record/284315 https://dx.doi.org/urn:doi:10.1021/acs.est.3c01664 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 TED2021-132627B-I00 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-110521GB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1005 |
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open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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