Absence of tangentially migrating glutamatergic neurons in the developing avian brain

Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and proliferation, respectively. These transient populatio...

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Authors: García-Moreno, Fernando, Anderton, Edward, Jankowska, Marta, Begbie, Jo, Encinas, Juan Manuel, Irimia Martínez, Manuel, Molnár, Zoltán
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/42823
Online Access:http://hdl.handle.net/10230/42823
http://dx.doi.org/10.1016/j.celrep.2017.12.032
Access Level:Open access
Keyword:Dbx1
Chick
Evo-devo
Evolution
Neocortex
Pallium
Telencephalon
Ventral pallium
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spelling Absence of tangentially migrating glutamatergic neurons in the developing avian brainGarcía-Moreno, FernandoAnderton, EdwardJankowska, MartaBegbie, JoEncinas, Juan ManuelIrimia Martínez, ManuelMolnár, ZoltánDbx1ChickEvo-devoEvolutionNeocortexPalliumTelencephalonVentral palliumSeveral neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and proliferation, respectively. These transient populations are primarily derived from other non-cortical pallial sources that migrate to the dorsal pallium. Are these migrations to the dorsal pallium conserved in amniotes or are they specific to mammals? Using in ovo electroporation, we traced the entire lineage of defined chick telencephalic progenitors. We found that several pallial sources that produce tangential migratory neurons in mammals only produced radially migrating neurons in the avian brain. Moreover, ectopic expression of VP-specific mammalian Dbx1 in avian brains altered neurogenesis but did not convert the migration into a mammal-like tangential movement. Together, these data indicate that tangential cellular contributions of glutamatergic neurons originate from outside the dorsal pallium and that pallial Dbx1 expression may underlie the generation of the mammalian neocortex during evolution.F.G.-M. was supported by Human Frontiers Science Program Long-Term Postdoctoral Fellowship Program LT000618/2011-L and currently holds an IKERBASQUE research fellowship. Z.M. holds research grants from the Biotechnology and Biological Sciences Research Council, the Wellcome Trust, and the Medical Research Council UK. M.I. is supported by grants from the European Research Council (ERC-StG-LS2-637591) and the Spanish Ministry of Economy and Competitiveness (BFU2014-55076-P to M.I. and “Centro de Excelencia Severo Ochoa 2013-2017” and SEV-2012-0208 to the Centre for Genomic Regulation [CRG]). We acknowledge the support of the CERCA Programme/Generalitat de Catalunya. J.M.E. holds MINECO SAF-2015-70866-R (with FEDER funds) and RyC-2012-11137 grants.Elsevier201920192018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42823http://dx.doi.org/10.1016/j.celrep.2017.12.032reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCell Rep. 2018; 22(1):96-109info:eu-repo/grantAgreement/ES/1PE/BFU2014-55076-Pinfo:eu-repo/grantAgreement/ES/1PE/SAF2015-70866-R© 2017 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/428232026-06-12T07:21:37Z
dc.title.none.fl_str_mv Absence of tangentially migrating glutamatergic neurons in the developing avian brain
title Absence of tangentially migrating glutamatergic neurons in the developing avian brain
spellingShingle Absence of tangentially migrating glutamatergic neurons in the developing avian brain
García-Moreno, Fernando
Dbx1
Chick
Evo-devo
Evolution
Neocortex
Pallium
Telencephalon
Ventral pallium
title_short Absence of tangentially migrating glutamatergic neurons in the developing avian brain
title_full Absence of tangentially migrating glutamatergic neurons in the developing avian brain
title_fullStr Absence of tangentially migrating glutamatergic neurons in the developing avian brain
title_full_unstemmed Absence of tangentially migrating glutamatergic neurons in the developing avian brain
title_sort Absence of tangentially migrating glutamatergic neurons in the developing avian brain
dc.creator.none.fl_str_mv García-Moreno, Fernando
Anderton, Edward
Jankowska, Marta
Begbie, Jo
Encinas, Juan Manuel
Irimia Martínez, Manuel
Molnár, Zoltán
author García-Moreno, Fernando
author_facet García-Moreno, Fernando
Anderton, Edward
Jankowska, Marta
Begbie, Jo
Encinas, Juan Manuel
Irimia Martínez, Manuel
Molnár, Zoltán
author_role author
author2 Anderton, Edward
Jankowska, Marta
Begbie, Jo
Encinas, Juan Manuel
Irimia Martínez, Manuel
Molnár, Zoltán
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Dbx1
Chick
Evo-devo
Evolution
Neocortex
Pallium
Telencephalon
Ventral pallium
topic Dbx1
Chick
Evo-devo
Evolution
Neocortex
Pallium
Telencephalon
Ventral pallium
description Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and proliferation, respectively. These transient populations are primarily derived from other non-cortical pallial sources that migrate to the dorsal pallium. Are these migrations to the dorsal pallium conserved in amniotes or are they specific to mammals? Using in ovo electroporation, we traced the entire lineage of defined chick telencephalic progenitors. We found that several pallial sources that produce tangential migratory neurons in mammals only produced radially migrating neurons in the avian brain. Moreover, ectopic expression of VP-specific mammalian Dbx1 in avian brains altered neurogenesis but did not convert the migration into a mammal-like tangential movement. Together, these data indicate that tangential cellular contributions of glutamatergic neurons originate from outside the dorsal pallium and that pallial Dbx1 expression may underlie the generation of the mammalian neocortex during evolution.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/42823
http://dx.doi.org/10.1016/j.celrep.2017.12.032
url http://hdl.handle.net/10230/42823
http://dx.doi.org/10.1016/j.celrep.2017.12.032
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cell Rep. 2018; 22(1):96-109
info:eu-repo/grantAgreement/ES/1PE/BFU2014-55076-P
info:eu-repo/grantAgreement/ES/1PE/SAF2015-70866-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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