The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway

[EN] Efficient sensory processing requires that the brain maximize its response to unexpected stimuli, while suppressing responsivity to expected events. Mismatch negativity (MMN) is an auditory event-related potential that occurs when a regular pattern is interrupted by an event that violates the e...

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Autores: Gutiérrez Parras, Gloria, Harms, Lauren, Michie, Patricia T., Malmierca, Manuel S., Parras, Gloria G., Valdés-Baizabal, Catalina
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/169113
Acesso em linha:http://hdl.handle.net/10366/169113
Access Level:acceso abierto
Palavra-chave:Cortex
Extracellular recording
Neurophysiology
Schizophrenia
Thalamus
2411.13 Fisiología de la Audición
2411.11 Neurofisiología
3209.90 Farmacología Experimental
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spelling The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathwayGutiérrez Parras, GloriaHarms, LaurenMichie, Patricia T.Malmierca, Manuel S.Parras, Gloria G.Valdés-Baizabal, CatalinaCortexExtracellular recordingNeurophysiologySchizophreniaThalamus2411.13 Fisiología de la Audición2411.11 Neurofisiología3209.90 Farmacología Experimental[EN] Efficient sensory processing requires that the brain maximize its response to unexpected stimuli, while suppressing responsivity to expected events. Mismatch negativity (MMN) is an auditory event-related potential that occurs when a regular pattern is interrupted by an event that violates the expected properties of the pattern. According to the predictive coding framework there are two mechanisms underlying the MMN: repetition suppression and prediction error. MMN has been found to be reduced in individuals with schizophrenia, an effect believed to be underpinned by glutamate N-methyl-d-aspartate receptor (NMDA-R) dysfunction. In the current study, we aimed to test how the NMDA-R antagonist, MK-801 in the anaesthetized rat, affected repetition suppression and prediction error processes along the auditory thalamocortical pathway. We found that low-dose systemic administration of MK-801 differentially affect thalamocortical responses, namely, increasing thalamic repetition suppression and cortical prediction error. Results demonstrate an enhancement of neuronal mismatch, also confirmed by large scale-responses. Furthermore, MK-801 produces faster and stronger dynamics of adaptation along the thalamocortical hierarchy. Clearly more research is required to understand how NMDA-R antagonism and dosage affects processes contributing to MMN. Nonetheless, because a low dose of an NMDA-R antagonist increased neuronal mismatch, the outcome has implications for schizophrenia treatment.We thank Drs. Javier Nieto-Diego and David Perez-Gonzalez for their technical support and constructive criticisms; and Drs. Nashat Abumaria and Juanita Todd for advice and constructive comments on the discussion. We also thank Dr. Marianny Janiree Pernía Rosales for helping with the histological photomicrography and Mr. Antonio Rivas Cornejo for the technical support. This work was supported by the Spanish MINECO (SAF2016-75803-P) and JCYL (SA023P17) to MSM. GGP held a fellowship from the Spanish MINECO (BES-2014-069113), and CVB held a fellowship from Mexican CONACyT (216652). LH was supported by an NHMRC project grant: APP1109283.Springer Nature202620262020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplicatio/pdfhttp://hdl.handle.net/10366/169113reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésSAF2016-75803-PSA023P17BES-2014-069113216652Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1691132026-06-07T06:28:51Z
dc.title.none.fl_str_mv The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
title The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
spellingShingle The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
Gutiérrez Parras, Gloria
Cortex
Extracellular recording
Neurophysiology
Schizophrenia
Thalamus
2411.13 Fisiología de la Audición
2411.11 Neurofisiología
3209.90 Farmacología Experimental
title_short The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
title_full The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
title_fullStr The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
title_full_unstemmed The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
title_sort The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the rat auditory thalamocortical pathway
dc.creator.none.fl_str_mv Gutiérrez Parras, Gloria
Harms, Lauren
Michie, Patricia T.
Malmierca, Manuel S.
Parras, Gloria G.
Valdés-Baizabal, Catalina
author Gutiérrez Parras, Gloria
author_facet Gutiérrez Parras, Gloria
Harms, Lauren
Michie, Patricia T.
Malmierca, Manuel S.
Parras, Gloria G.
Valdés-Baizabal, Catalina
author_role author
author2 Harms, Lauren
Michie, Patricia T.
Malmierca, Manuel S.
Parras, Gloria G.
Valdés-Baizabal, Catalina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cortex
Extracellular recording
Neurophysiology
Schizophrenia
Thalamus
2411.13 Fisiología de la Audición
2411.11 Neurofisiología
3209.90 Farmacología Experimental
topic Cortex
Extracellular recording
Neurophysiology
Schizophrenia
Thalamus
2411.13 Fisiología de la Audición
2411.11 Neurofisiología
3209.90 Farmacología Experimental
description [EN] Efficient sensory processing requires that the brain maximize its response to unexpected stimuli, while suppressing responsivity to expected events. Mismatch negativity (MMN) is an auditory event-related potential that occurs when a regular pattern is interrupted by an event that violates the expected properties of the pattern. According to the predictive coding framework there are two mechanisms underlying the MMN: repetition suppression and prediction error. MMN has been found to be reduced in individuals with schizophrenia, an effect believed to be underpinned by glutamate N-methyl-d-aspartate receptor (NMDA-R) dysfunction. In the current study, we aimed to test how the NMDA-R antagonist, MK-801 in the anaesthetized rat, affected repetition suppression and prediction error processes along the auditory thalamocortical pathway. We found that low-dose systemic administration of MK-801 differentially affect thalamocortical responses, namely, increasing thalamic repetition suppression and cortical prediction error. Results demonstrate an enhancement of neuronal mismatch, also confirmed by large scale-responses. Furthermore, MK-801 produces faster and stronger dynamics of adaptation along the thalamocortical hierarchy. Clearly more research is required to understand how NMDA-R antagonism and dosage affects processes contributing to MMN. Nonetheless, because a low dose of an NMDA-R antagonist increased neuronal mismatch, the outcome has implications for schizophrenia treatment.
publishDate 2020
dc.date.none.fl_str_mv 2020
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/169113
url http://hdl.handle.net/10366/169113
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv SAF2016-75803-P
SA023P17
BES-2014-069113
216652
dc.rights.none.fl_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv applicatio/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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