Avances en la valoración de la salud ósea en el trasplantado renal

Bone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that this has been known for decades, to date, an appropriate diagnostic strategy...

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Autores: Pérez-Sáez, María José, Prieto-Alhambra, Daniel, Díez Pérez, Adolfo, Pascual Santos, Julio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/35025
Acceso en línea:http://hdl.handle.net/10230/35025
http://dx.doi.org/10.1016/j.nefro.2017.04.002
Access Level:acceso abierto
Palabra clave:Ronyons--Trasplantació
Ossos -- Malalties
Fractures
Bone microindentation
Bone mineral disease
Bone strength
Enfermedad mineral ósea
Fracturas
Kidney transplant
Microindentación ósea
Resistencia ósea
Score trabecular óseo
Trabecular bone score
Trasplante renal
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spelling Avances en la valoración de la salud ósea en el trasplantado renalPérez-Sáez, María JoséPrieto-Alhambra, DanielDíez Pérez, AdolfoPascual Santos, JulioRonyons--TrasplantacióOssos -- MalaltiesFracturesBone microindentationBone mineral diseaseBone strengthEnfermedad mineral óseaFracturasFracturesKidney transplantMicroindentación óseaResistencia óseaScore trabecular óseoTrabecular bone scoreTrasplante renalBone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that this has been known for decades, to date, an appropriate diagnostic strategy has yet to be established. Apart from bone biopsy, which is invasive and scarcely used, no other technique is available to accurately establish the risk of fracture in kidney patients. Techniques applied to the general population, such as bone densitometry, have not been subjected to sufficient external validation and their use is not systematic. This means that the identification of patients at risk of fracture and therefore those who are candidates for preventive strategies is an unmet need. Bone strength, defined as the ability of the bone to resist fracture, is determined by bone mineral density (measured by bone densitometry), trabecular architecture and bone tissue quality. The trabecular bone score estimates bone microarchitecture, and low values have been described as an independent predictor of increased fracture risk. Bone microindentation is a minimally invasive technique that measures resistance of the bone to micro-cracks (microscopic separation of mineralised collagen fibres), and therefore bone tissue biomechanical properties. The superiority over bone densitometry of the correlation between the parameters measured by trabecular bone score and microindentation with the risk of fracture in diverse populations led us to test its feasibility in chronic kidney disease and kidney transplant patients.Elsevier201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35025http://dx.doi.org/10.1016/j.nefro.2017.04.002reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)EspañolNefrologia. 2018 Jan - Feb;38(1):27-33© 2017 Sociedad Española de Nefrología. Publicado por Elsevier España. S.L.U. Este es un artículo Open Access bajo la licencia CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/).https://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10230/350252026-05-29T05:05:01Z
dc.title.none.fl_str_mv Avances en la valoración de la salud ósea en el trasplantado renal
title Avances en la valoración de la salud ósea en el trasplantado renal
spellingShingle Avances en la valoración de la salud ósea en el trasplantado renal
Pérez-Sáez, María José
Ronyons--Trasplantació
Ossos -- Malalties
Fractures
Bone microindentation
Bone mineral disease
Bone strength
Enfermedad mineral ósea
Fracturas
Fractures
Kidney transplant
Microindentación ósea
Resistencia ósea
Score trabecular óseo
Trabecular bone score
Trasplante renal
title_short Avances en la valoración de la salud ósea en el trasplantado renal
title_full Avances en la valoración de la salud ósea en el trasplantado renal
title_fullStr Avances en la valoración de la salud ósea en el trasplantado renal
title_full_unstemmed Avances en la valoración de la salud ósea en el trasplantado renal
title_sort Avances en la valoración de la salud ósea en el trasplantado renal
dc.creator.none.fl_str_mv Pérez-Sáez, María José
Prieto-Alhambra, Daniel
Díez Pérez, Adolfo
Pascual Santos, Julio
author Pérez-Sáez, María José
author_facet Pérez-Sáez, María José
Prieto-Alhambra, Daniel
Díez Pérez, Adolfo
Pascual Santos, Julio
author_role author
author2 Prieto-Alhambra, Daniel
Díez Pérez, Adolfo
Pascual Santos, Julio
author2_role author
author
author
dc.subject.none.fl_str_mv Ronyons--Trasplantació
Ossos -- Malalties
Fractures
Bone microindentation
Bone mineral disease
Bone strength
Enfermedad mineral ósea
Fracturas
Fractures
Kidney transplant
Microindentación ósea
Resistencia ósea
Score trabecular óseo
Trabecular bone score
Trasplante renal
topic Ronyons--Trasplantació
Ossos -- Malalties
Fractures
Bone microindentation
Bone mineral disease
Bone strength
Enfermedad mineral ósea
Fracturas
Fractures
Kidney transplant
Microindentación ósea
Resistencia ósea
Score trabecular óseo
Trabecular bone score
Trasplante renal
description Bone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that this has been known for decades, to date, an appropriate diagnostic strategy has yet to be established. Apart from bone biopsy, which is invasive and scarcely used, no other technique is available to accurately establish the risk of fracture in kidney patients. Techniques applied to the general population, such as bone densitometry, have not been subjected to sufficient external validation and their use is not systematic. This means that the identification of patients at risk of fracture and therefore those who are candidates for preventive strategies is an unmet need. Bone strength, defined as the ability of the bone to resist fracture, is determined by bone mineral density (measured by bone densitometry), trabecular architecture and bone tissue quality. The trabecular bone score estimates bone microarchitecture, and low values have been described as an independent predictor of increased fracture risk. Bone microindentation is a minimally invasive technique that measures resistance of the bone to micro-cracks (microscopic separation of mineralised collagen fibres), and therefore bone tissue biomechanical properties. The superiority over bone densitometry of the correlation between the parameters measured by trabecular bone score and microindentation with the risk of fracture in diverse populations led us to test its feasibility in chronic kidney disease and kidney transplant patients.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35025
http://dx.doi.org/10.1016/j.nefro.2017.04.002
url http://hdl.handle.net/10230/35025
http://dx.doi.org/10.1016/j.nefro.2017.04.002
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.relation.none.fl_str_mv Nefrologia. 2018 Jan - Feb;38(1):27-33
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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