Dataset of Prediction of Antileishmanial Compounds: General Model, Preparation, and Evaluation of 2‑Acylpyrrole Derivatives

Results of the computational study of the new series of 2-acylpyrrole derivatives.

Detalles Bibliográficos
Autores: Santiago, Carlos, Ortega Tenezaca, Bernabé, Barbolla, Iratxe, Fundora, Brenda, Arrasate, Sonia, Dea-Ayuela, M. Auxiliadora, González-Díaz, Humberto, Sotomayor, Nuria, Lete, Esther
Tipo de recurso: conjunto de datos
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/331608
Acceso en línea:http://hdl.handle.net/10261/331608
Access Level:acceso abierto
Palabra clave:Potential target proteins
Friendly interface making
Relative biological activity
700 activity scores
Antileishmanial compound candidates
5bd
5bc
Obtain ifptml models
Different ml algorithms
b
50
Leishmanicidal activity
vs
Vitro
Leishmania
Antileishmanial hits
Throughput screening
Svm ),
rf ),
Random forests
Performed calculating
One strategy
Logistic regression
j774 cells
Large space
General models
Evaluated finding
Computational high
Chembl dataset
Cell lines
Approximately 6
87 μm
28 derivatives
100 μg
Descripción
Sumario:Results of the computational study of the new series of 2-acylpyrrole derivatives.