Enhancing Polyphenol Delivery and Efficacy Using Functionalized Gold Nanoparticles: Antioxidant and Antibacterial Properties

Research into the use of nanoparticles to enhance the delivery and efficacy of polyphenols is a topic of growing interest in the fields of nanotechnology, pharmacology and food science. Nanoparticles, due to their small size and high surface area, can improve the stability, solubility and bioavailab...

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Detalles Bibliográficos
Autores: Bouaouz Idrissi, Siham|||0000-0002-0640-9822, Chávez Peraza, Miriam|||0000-0002-5512-7485, Peña González, Cornelia E., Rojas Tizón, José Daniel|||0000-0002-4404-4668, Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948, Ortega Lopez, Paula|||0000-0003-0377-5429, Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/67641
Acceso en línea:http://hdl.handle.net/10017/67641
https://dx.doi.org/10.1155/bca/3836765
Access Level:acceso abierto
Palabra clave:Antibacterial
Antioxidant
Dendron
Gold nanoparticles
Química
Chemistry
Descripción
Sumario:Research into the use of nanoparticles to enhance the delivery and efficacy of polyphenols is a topic of growing interest in the fields of nanotechnology, pharmacology and food science. Nanoparticles, due to their small size and high surface area, can improve the stability, solubility and bioavailability of polyphenols. Combining polyphenols with other bioactive compounds within nanoparticles can create synergistic effects, enhancing their overall therapeutic potential. In this work, we present a new polyethylene glycol (PEG) capping ligand modified with caffeic acid (CA), HS-PEG-CA and two types of gold nanoparticles: (i) coated with a PEG-thiol derivative functionalized with CA (HS-PEG-CA) (homofuncionalized NP) and (ii) HS-PEG-CA cationic carbosilane dendrons with antibacterial properties (heterofuncionalized NP). The antioxidant capacity of the CA, in three systems, has been studied by different techniques such as FRAP, DDPH and cyclic voltammetry, demonstrating that it is preserved when it is supported on the NP and increases when it is part of the PEG ligand. In addition, heterofuntionalized NP showed activity against S. aureus and HS-PEG2K-CA ligand can effectively anchor to gold substrates.

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