An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media

The preparation of a fluorogenic sensory material for the detection of biomolecules is described. Strategic functionalisation and copolymerisation of a water insoluble organic sensory molecule with hydrophilic comonomers yielded a crosslinked, water-swellable, easy-to-manipulate solid system for wat...

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Autores: Vallejos Calzada, Saúl, Estévez Bolívar, Pedro Antonio, Ibeas Cortes, Saturnino, García García, Félix Clemente, Serna Arenas, Felipe, García Pérez, José Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/4359
Acceso en línea:http://hdl.handle.net/10259/4359
Access Level:acceso abierto
Palabra clave:sensory materials
chemosensor
fluorogenic sensor
biomolecules
sensing biomolecules
Chemistry
Química
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spelling An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous MediaVallejos Calzada, SaúlEstévez Bolívar, Pedro AntonioIbeas Cortes, SaturninoGarcía García, Félix ClementeSerna Arenas, FelipeGarcía Pérez, José Miguelsensory materialschemosensorfluorogenic sensorbiomoleculessensing biomoleculesChemistryQuímicaThe preparation of a fluorogenic sensory material for the detection of biomolecules is described. Strategic functionalisation and copolymerisation of a water insoluble organic sensory molecule with hydrophilic comonomers yielded a crosslinked, water-swellable, easy-to-manipulate solid system for water ‘‘dip-in’’ fluorogenic coenzyme A, cysteine, and glutathione detection by means of host-guest interactions. The sensory material was a membrane with gel-like behaviour, which exhibits a change in fluorescence behaviour upon swelling with a water solution of the target molecules. The membrane follows a “turn-on” pattern, which permits the titration of the abovementioned biomolecules. In this way, the water insoluble sensing motif can be exploited in aqueous media. The sensory motif within the membrane is a chemically anchored piperazinedione-derivative with a weakly bound Hg(II). The response is caused by the displacement of the cation from the membrane due to a stronger complexation with the biomolecules, thus releasing the fluorescent sensory moieties within the membraneSpanish Ministerio de Ciencia e Innovación—Feder (MAT2011-22544) and by the Junta de Castilla y León (BU001A10-2)MDPI201720172012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/4359reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésSensors, 2012, V. 12, n. 3, p. 2969-2982http://dx.doi.org/10.3390/s120302969Attribution 3.0 Unportedhttp://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/43592026-05-28T07:56:11Z
dc.title.none.fl_str_mv An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
title An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
spellingShingle An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
Vallejos Calzada, Saúl
sensory materials
chemosensor
fluorogenic sensor
biomolecules
sensing biomolecules
Chemistry
Química
title_short An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
title_full An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
title_fullStr An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
title_full_unstemmed An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
title_sort An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
dc.creator.none.fl_str_mv Vallejos Calzada, Saúl
Estévez Bolívar, Pedro Antonio
Ibeas Cortes, Saturnino
García García, Félix Clemente
Serna Arenas, Felipe
García Pérez, José Miguel
author Vallejos Calzada, Saúl
author_facet Vallejos Calzada, Saúl
Estévez Bolívar, Pedro Antonio
Ibeas Cortes, Saturnino
García García, Félix Clemente
Serna Arenas, Felipe
García Pérez, José Miguel
author_role author
author2 Estévez Bolívar, Pedro Antonio
Ibeas Cortes, Saturnino
García García, Félix Clemente
Serna Arenas, Felipe
García Pérez, José Miguel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv sensory materials
chemosensor
fluorogenic sensor
biomolecules
sensing biomolecules
Chemistry
Química
topic sensory materials
chemosensor
fluorogenic sensor
biomolecules
sensing biomolecules
Chemistry
Química
description The preparation of a fluorogenic sensory material for the detection of biomolecules is described. Strategic functionalisation and copolymerisation of a water insoluble organic sensory molecule with hydrophilic comonomers yielded a crosslinked, water-swellable, easy-to-manipulate solid system for water ‘‘dip-in’’ fluorogenic coenzyme A, cysteine, and glutathione detection by means of host-guest interactions. The sensory material was a membrane with gel-like behaviour, which exhibits a change in fluorescence behaviour upon swelling with a water solution of the target molecules. The membrane follows a “turn-on” pattern, which permits the titration of the abovementioned biomolecules. In this way, the water insoluble sensing motif can be exploited in aqueous media. The sensory motif within the membrane is a chemically anchored piperazinedione-derivative with a weakly bound Hg(II). The response is caused by the displacement of the cation from the membrane due to a stronger complexation with the biomolecules, thus releasing the fluorescent sensory moieties within the membrane
publishDate 2012
dc.date.none.fl_str_mv 2012
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10259/4359
url http://hdl.handle.net/10259/4359
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sensors, 2012, V. 12, n. 3, p. 2969-2982
http://dx.doi.org/10.3390/s120302969
dc.rights.none.fl_str_mv Attribution 3.0 Unported
http://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Unported
http://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname:Universidad de Burgos (UBU)
instname_str Universidad de Burgos (UBU)
reponame_str Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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