A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individual...

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Authors: Yengo, Loic|||0000-0002-4272-9305, Vedantam, Sailaja|||0000-0003-3892-7461, Marouli, Eirini|||0000-0001-6179-1609, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori|||0000-0003-3618-9717, Graff, Marielisa, Eliasen, Anders U., Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D., Graham, Sarah E.|||0000-0003-1271-2489, Mukamel, Ronen E., Spracklen, Cassandra N.|||0000-0003-3590-7182, Yin, Xianyong|||0000-0001-6454-2384, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H., Ji, Yingjie, Karaderi, Tugce|||0000-0001-9763-8139, Lin, Kuang, Lüll, Kreete, Malden, Deborah|||0000-0003-0567-8294, Medina-Gomez, Carolina|||0000-0001-7999-5538, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling|||0000-0002-1233-7642, Vrieze, Scott, Ahluwalia, Tarunveer Singh|||0000-0002-7464-3354, Akiyama, Masato|||0000-0002-1879-5476, Allison, Matthew A., Álvarez, Marcus, Andersen, Mette korre|||0000-0001-8227-1469, Ani, Alireza|||0000-0002-7868-3118, Appadurai, Vivek, Arbeeva, Liubov|||0000-0001-5004-419X, Bhaskar, Seema, Bielak, Lawrence F.|||0000-0002-3443-8030, Bollepalli, Sailalitha|||0000-0002-8773-7149, Bonnycastle, Lori L., Bork-Jensen, Jette, Bradfield, Jonathan Paul|||0000-0001-8758-2071, Bradford, Yuki, Braund, Peter S.|||0000-0001-8540-5709, Brody, Jennifer A.|||0000-0001-8509-148X, Burgdorf, Kristoffer S., Cade, Brian E.|||0000-0003-1424-0673, Cai, H., Cai, Qiuyin, Campbell, Archie|||0000-0003-0198-5078, Cañadas-Garre, Marisa|||0000-0003-1103-5658, Catamo, Eulalia|||0000-0002-4701-9134, Chai, Jin-Fang|||0000-0003-3770-1137, Chai, Xiaoran, Chang, Liching, Chang, Yicheng, Chen, Chien Hsiun, Chesi, Alessandra|||0000-0002-0954-7446, Choi, Seunghoan, Chung, Renhua, Cocca, Massimiliano|||0000-0002-1127-7596, Concas, Maria Pina|||0000-0003-3598-2537, Couture, Christian Y., Cuellar-Partida, Gabriel|||0000-0001-7648-4097, Danning, Rebecca D., Daw, E. Warwick, Degenhard, Frauke, Delgado, Graciela E.|||0000-0002-1272-7210, Delitala, Alessandro|||0000-0003-1729-8969, Demirkan, Ayşe|||0000-0002-7546-0867, Deng, Xuan|||0000-0003-0918-817X, Devineni, Poornima, Dietl, Alexander|||0000-0002-4091-8620, Dimitriou, Maria E., Dimitrov, Latchezar M., Dorajoo, Rajkumar|||0000-0001-6608-2051, Ekici, Arif B., Engmann, Jorgen|||0000-0001-7015-7773, Fairhurst-Hunter, Zammy, Farmaki, Aliki Eleni, Faul, Jessica D.|||0000-0002-6969-6478, Fernandez-Lopez, Juan Carlos|||0000-0003-3680-4193, Forer, Lukas|||0000-0003-2139-7329, Francescatto, Margherita, Freitag-Wolf, Sandra, Fuchsberger, Christian|||0000-0002-5918-8947, Galesloot, Tessel E., Gao, Yan, Gao, Zishan|||0000-0003-1299-0286, Geller, Frank, Giannakopoulou, Olga, Giulianini, Franco, Gjesing, Anette Prior, Goel, Anuj|||0000-0003-2307-4021, Gordon, Scott D.|||0000-0001-7623-328X, Gorski, Mathias M., Grove, Jakob|||0000-0003-2284-5744, Guo, Xiuqing, Gustafsson, S.|||0000-0001-5894-0351, Haessler, Jeffrey W., Hansen, Thomas Folkmann, Havulinna, Aki Samuli, Haworth, S.J., He, Jing, Heard-Costa, Nancy L., Hebbar, Prashantha|||0000-0001-6560-7063, Hindy, George|||0000-0002-7257-9299, Ho, Yuk Lam Anne, Hofer, Edith, Holliday, Elizabeth|||0000-0002-4066-6224, Horn, Katrin, Hornsby, Whitney E., Hottenga, Jouke Jan|||0000-0002-5668-2368, Huang, Hongyan, Huang, Jie, Huerta-Chagoya, Alicia|||0000-0001-6218-3904, Huffman, Jennifer E.|||0000-0002-9672-2491, Hung, Yijen, Huo, Shaofeng, Hwang, Mi-yeong, Iha, Hiroyuki|||0000-0003-4261-2067, Ikeda, Daisuke D.|||0000-0001-8403-0327, Isono, Masato, Jackson, Anne U.|||0000-0002-9672-2547, Jäger, Susanne, Jansen, Iris E.|||0000-0003-1901-8131, Johansson, Ingegerd, Jonas, Jost Bruno, Jonsson, Anna Elisabet, Jørgensen, Torben J., Kalafati, IP.|||0000-0001-5572-7491, Kanai, Masahiro|||0000-0001-5165-4408, Kanoni, Stavroula|||0000-0002-1691-9615, Kårhus, Line Lund, Kasturiratne, Anuradhani, Katsuya, Tomohiro|||0000-0002-8892-8828, Kawaguchi, Takahisa, Kember, Rachel L.|||0000-0001-8820-2659, Kentistou, Katherine A.|||0000-0002-5816-664X, Kim, Hanna, Kim, Young-jin, Kleber, Marcus Edi, Knol, Maria J.|||0000-0002-3597-1531, Kurbasic, Azra, Lauzon, Marie, Le, Phuong, Lea, Rodney A., Lee, Jongyoung, Leonard, Hampton L.|||0000-0003-2390-8110, Li, Shengchao Alfred, Li, Xiaoyin, Liang, Jingjing, Lin, Honghuang, Lin, Shihyi, Liu, Jun|||0000-0001-5288-3042, Liu, Xueping, Lo, Ken Sin, Long, Jirong, Lores-Motta, Laura, Luan, Jian'fan N. An, Lyssenko, Valeriya, Lyytikäinen, Leo Pekka, Mahajan, Anubha|||0000-0001-5585-3420, Mamakou, Vasiliki, Mangino, Massimo, Manichaikul, Ani W., Marten, Jonathan|||0000-0001-6916-2014, Mattheisen, Manuel|||0000-0002-8442-493X, Mavarani, Laven, McDaid, Aaron F., Meidtner, Karina, Melendez, Tori L., Mercader, Josep M.|||0000-0001-8494-3660, Milaneschi, Yuri|||0000-0002-3697-6617, Miller, Jason E., Millwood, Iona Y., Mishra, Pashupati P.|||0000-0001-5177-3431, Mitchell, Ruth E., Møllehave, Line Tang|||0000-0001-7116-9346, Morgan, Anna, Mucha, Soeren, Munz, Matthias|||0000-0002-4728-3357, Nakatochi, Masahiro|||0000-0002-1838-4837, Nelson, Christopher P., Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A., Nolte, Ilja M.|||0000-0001-5047-4077, Nongmaithem, Suraj S.|||0000-0001-5390-0449, Noordam, Raymond|||0000-0001-7801-809X, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva R.B., Petersen, Liselotte V., Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz|||0000-0001-6349-3955, Preuss, Michael H., Pyarajan, Saiju, Raffield, Laura M., Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Dennis, Rayner, Nigel W., Riveros, Carlos, Rohde, Rebecca, Ruggiero, Daniela|||0000-0003-3898-7827, Ruotsalainen, Sanni E.|||0000-0002-1631-4069, Ryan, Kathleen A., Sabater-Lleal, Maria|||0000-0002-0128-379X, Saxena, Richa, Scholz, Markus|||0000-0002-4059-1779, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, J.H., Sidore, Carlo|||0000-0001-7504-7477, Sitlani, Collen M.|||0000-0001-7656-7482, Slieker, Roderick C., Smit, Roelof A. J., Smith, Albert V., Smith, Jennifer A.|||0000-0002-3575-5468, Smyth, Laura J.|||0000-0001-6419-4826, Southam, Lorraine, Steinthorsdottir, Valgerdur, Sun, Liang, Takeuchi, Fumihiko, Tallapragada, Divya Sri Priyanka, Taylor, Kent|||0000-0002-2756-4370, Tayo, Bamidele O., Tcheandjieu, Catherine, Terzikhan, Natalie, Tesolin, Paola|||0000-0002-5238-6422, Teumer, Alexander|||0000-0002-8309-094X, Theusch, Elizabeth|||0000-0002-5678-759X, Thompson, Deborah J., Thorleifsson, Gudmar|||0000-0003-4623-9087, Timmers, Paul R. H. J., Trompet, Stella|||0000-0001-5006-0528, Turman, Constance, Vaccargiu, Simona, van der Laan, Sander W.|||0000-0001-6888-1404, van der Most, Peter J.|||0000-0001-8450-3518, van Klinken, Jan Bert, van Setten, Jessica A., Verma, Shefali Setia, Verweij, Niek|||0000-0002-4303-7685, Veturi, Yogasudha C., Wang, Carol A.|||0000-0002-4301-3974, Wang, Chaolong, Wang, Lihua, Wang, Zhe|||0000-0003-0786-9887, Warren, Helen R., Bin Wei, Wen, Wickremasinghe, Ananda|||0000-0002-6174-6784, Wielscher, Matthias|||0000-0003-4138-1383, Wiggins, Kerri L.|||0000-0003-2749-1279, Winsvold, Bendik Slagsvold|||0000-0003-4171-8919, Wong, Andrew|||0000-0003-2079-4779, Wu, Yang|||0000-0002-0128-7280, Wuttke, Matthias|||0000-0003-3420-5082, Xia, Rui|||0000-0003-2409-1181, Xie, Tian, Yamamoto, Ken, Yang, Jingyun, Yao, Jie, Young, Hannah|||0000-0002-4248-9612, Yousri, Noha A.|||0000-0003-1918-0331, Yu, Lei, Zeng, Lingyao, Zhang, Weihua, Zhang, Xinyuan, Zhao, Jinghua, Zhao, Wei|||0000-0002-4839-6791, Zhou, Wei, Zimmermann, Martina E.|||0000-0002-6916-4404, Zoledziewska, Magdalena|||0000-0002-3033-6133, Adair, Linda S., Adams, Hieab H. H.|||0000-0003-3687-2508, Aguilar-Salinas, Carlos Alberto, Al-Mulla, Fahd|||0000-0001-5409-3829, Arnett, Donna|||0000-0003-2219-657X, Asselbergs, Folkert W.|||0000-0002-1692-8669, Åsvold, Bjørn Olav|||0000-0003-3837-2101, Attia, John Richard, Banas, Bernhard|||0000-0003-2076-2195, Bandinelli, Stefania|||0000-0002-6491-0850, Bennett, David Alan, Bergler, Tobias, Bharadwaj, Dwaipayan, Biino, Ginevra|||0000-0002-9936-946X, Bisgaard, Hans, Boerwinkle, Eric|||0000-0001-8813-0544, Böger, Carsten A., Bønnelykke, Klaus, Boomsma, Dorret I.|||0000-0002-7099-7972, Børglum, Anders D.|||0000-0001-8627-7219, Borja, Judith B., Bouchard, Claude|||0000-0002-0048-491X, Bowden, Donald W., Brandslund, Ivan, Brumpton, Ben, Buring, Julie E., Caulfield, Mark|||0000-0001-9295-3594, Chambers, John C., Chandak, Giriraj R., Chanock, Stephen|||0000-0002-2324-3393, Chaturvedi, Nish, Chen, Yii Der Ida, Chen, Zhengming|||0000-0001-6423-105X, Cheng, Ching-Yu|||0000-0003-0655-885X, Christophersen, Ingrid E., Ciullo, Marina|||0000-0002-9621-9984, Cole, John W.|||0000-0001-9263-8930, Collins, Francis S.|||0000-0002-1023-7410, Cooper, Richard S., Cruz, Miguel, Cucca, Francesco|||0000-0002-7414-1995, Cupples, L. Adrienne, Cutler, Michael J., Damrauer, Scott M.|||0000-0001-8009-1632, Dantoft, Thomas M., de Borst, Gert J., de Groot, Lisette C.P.G.M.|||0000-0003-2778-2789, De Jager, Philip L.|||0000-0002-8057-2505, de Kleijn, D.P.V.|||0000-0003-2714-2140, Janaka de Silva, H., Dedoussis, George V., den Hollander, Anneke I., Du, Shufa, Easton, Douglas F.|||0000-0003-2444-3247, Elders, Petra J. M., Eliassen, A. Heather Heather, Ellinor, Patrick T., Elmståhl, Sölve, Erdmann, Jeanette|||0000-0002-4486-6231, Evans, Michele K., Fatkin, Diane, Feenstra, Bjarke|||0000-0003-1478-649X, Feitosa, Mary|||0000-0002-0933-2410, Ferrucci, Luigi, Ford, Ian, Fornage, Myriam|||0000-0003-0677-8158, Franke, Andre|||0000-0003-1530-5811, Franks, Paul W.|||0000-0002-0520-7604, Freedman, Barry I.|||0000-0003-0275-5530, Gasparini, Paolo, Gieger, Christian|||0000-0001-6986-9554, Girotto, Giorgia|||0000-0003-4507-6589, Goddard, Michael E., Golightly, Yvonne M., Gonzalez-Villalpando, Clicerio, Gordon-Larsen, P., Grallert, H., Grant, Struan F. A.|||0000-0003-2025-5302, Grarup, Niels|||0000-0001-5526-1070, Griffiths, L., Gudnason, V., Haiman, C., Hakonarson, Hakon|||0000-0003-2814-7461, Hansen, Torben|||0000-0001-8748-3831, Hartman, C.A., Hattersley, A.T., Hayward, Caroline|||0000-0002-9405-9550, Heckbert, S.R., Heng, C.K., Hengstenberg, C., Hewitt, Alex W.|||0000-0002-5123-5999, Hishigaki, H., Hoyng, C.B., Huang, Paul L., Huang, W., Hunt, S.C., Hveem, K., Hyppönen, E., Iacono, William, Ichihara, S., Ikram, M.A., Isasi, C.R., Jackson, R.D., Jarvelin, Marjo-Riitta|||0000-0002-2149-0630, Jin, Zi-Bing, Jöckel, K.H., Joshi, P.K., Jousilahti, P., Jukema, J.W., Kähönen, M., Kamatani, Yoichiro|||0000-0001-8748-5597, Kang, K.D., Kaprio, Jaakko|||0000-0002-3716-2455, Kardia, S.L.R., Karpe, F., Kato, N., Kee, F., Kessler, T., Khera, Amit V., Khor, C.C., Kiemeney, Lambertus A., Kim, B.J., Kim, E.K., Kim, H.L., Kirchhof, P., Kivimaki, Mika|||0000-0002-4699-5627, Koh, W.P., Koistinen, H.A., Kolovou, G.D., Kooner, J.S., Kooperberg, C., Köttgen, A., Kovacs, P., Kraaijeveld, A., Kraft, Peter, Krauss, R.M., Kumari, M., Kutalik, Zoltan|||0000-0001-8285-7523, Laakso, Markku|||0000-0002-3394-7749, Lange, Leslie A., Langenberg, C., Launer, L.J., Le Marchand, L., Lee, H., Lee, N.R., Lehtimäki, T., Li, H., Li, L., Lieb, Wolfgang|||0000-0003-2544-4460, Lin, X., Lind, Lars, Linneberg, Allan|||0000-0002-0994-0184, Liu, Ching-Ti, Liu, Jianjun|||0000-0002-3255-3019, Loeffler, Markus, London, Barry, Lubitz, Steven A., Lye, Stephen J., Mackey, David A., Mägi, Reedik, Magnusson, Patrik K. E.|||0000-0002-7315-7899, Marcus, Gregory M.|||0000-0001-5197-7696, Vidal, Pedro M., Martin, Nicholas G.|||0000-0003-4069-8020, März, Winfried|||0000-0001-6083-8946, Matsuda, Fumihiko, McGarrah, Robert W., McGue, Matt|||0000-0002-5580-1433, McKnight, Amy Jayne|||0000-0002-7482-709X, Medland, Sarah Elizabeth|||0000-0003-1382-380X, Mellström, Dan|||0000-0003-2761-3723, Metspalu, Andres|||0000-0002-3718-796X, Mitchell, Braxton|||0000-0003-4920-4744, Mitchell, Paul, Mook-Kanamori, Dennis O., Morris, Andrew D., Mucci, Lorelei A., Munroe, Patricia B.|||0000-0002-4176-2947, Nalls, Mike A., Nazarian, Saman, Nelson, Amanda E., Neville, Matt J.|||0000-0002-6004-5433, Newton-Cheh, Christopher, Nielsen, Christopher S., Nöthen, Markus M.|||0000-0002-8770-2464, Ohlsson, Claes|||0000-0002-9633-2805, Oldehinkel, Albertine J.|||0000-0003-3925-3913, Orozco, Lorena|||0000-0002-5801-9180, Pahkala, Katja, Pajukanta, Päivi, Palmer, Colin N. A., Parra, Esteban J.|||0000-0002-2057-8577, Pattaro, Cristian|||0000-0002-4119-0109, Pedersen, Oluf, Pennell, Craig E.|||0000-0002-0937-6165, Penninx, Brenda W. J. H., Pérusse, Louis|||0000-0001-6440-9698, Peters, Annette|||0000-0001-6645-0985, Peyser, Patricia A., Porteous, David J.|||0000-0003-1249-6106, Posthuma, Danielle|||0000-0001-7582-2365, Power, Chris, Pramstaller, Peter P., Province, Michael A.|||0000-0001-6102-774X, Qi, Qibin, Qu, Jia, Rader, Daniel J., Raitakari, Olli T., Ralhan, Sarju, Rallidis, Loukianos S., Rao, Dabeeru C., Redline, Susan, Reilly, Dermot F., Reiner, Alexander P., Rhee, Sang Youl|||0000-0003-0119-5818, Ridker, Paul M., Rienstra, Michiel|||0000-0002-2581-070X, Ripatti, Samuli|||0000-0002-0504-1202, Ritchie, Marylyn D.|||0000-0002-1208-1720, Roden, Dan M., Rosendaal, Frits|||0000-0003-2558-7496, Rotter, Jerome I.|||0000-0001-7191-1723, Rudan, Igor|||0000-0001-6993-6884, Rutters, Femke, Sabanayagam, Charumathi|||0000-0002-4042-4719, Saleheen, Danish|||0000-0001-6193-020X, Salomaa, Veikko|||0000-0001-7563-5324, Samani, Nilesh J., Sanghera, Dharambir K., Sattar, Naveed|||0000-0002-1604-2593, Schmidt, Börge, Schmidt, Helena|||0000-0001-9773-9992, Schmidt, Reinhold, Schulze, Matthias B., Schunkert, Heribert|||0000-0001-6428-3001, Scott, Laura J.|||0000-0002-4886-5084, Scott, Rodney J.|||0000-0001-7724-3404, Sever, Peter, Shiroma, Eric J., Shoemaker, M. Benjamin, Shu, Xiao-Ou, Simonsick, Eleanor M., Sims, Mario, Singh, Jai Rup, Singleton, Andrew B.|||0000-0001-5606-700X, Sinner, Moritz F., Smith, J. Gustav, Snieder, Harold|||0000-0003-1949-2298, Spector, Tim|||0000-0002-9795-0365, Stampfer, Meir J., Stark, Klaus J., Strachan, David P., 't Hart, Leen M., Tabara, Yasuharu, Tang, Hua, Tardif, J.C., Thanaraj, T.A., Timpson, N.J., Tönjes, A., Tremblay, A., Tuomi, T., Tuomilehto, J., Tusié-Luna, M.T., Uitterlinden, André G.|||0000-0002-7276-3387, van Dam, Rob M., van der Harst, Pim|||0000-0002-2713-686X, Van der Velde, Nathalie, van Duijn, Cornelia M.|||0000-0002-2374-9204, van Schoor, N.M., Vitart, Veronique|||0000-0002-4991-3797, Völker, U., Vollenweider, P., Völzke, Henry|||0000-0001-7003-399X, Wacher-Rodarte, N.H., Walker, M., Wang, Y.X., Wareham, N.J., Watanabe, R.M., Watkins, Hugh, Weir, D.R., Werge, Thomas M., Widen, E., Wilkens, Lynne R., Willemsen, Gonneke|||0000-0003-3755-0236, Willett, Walter C., Wilson, James F.|||0000-0001-5751-9178, Wong, Tien-Yin, Woo, Jeong-Taek|||0000-0001-9201-0713, Wright, Alan F., Wu, Jer-Yuarn, Xu, Huichun|||0000-0001-8118-9607, Yajnik, Chittaranjan S., Yokota, Mitsuhiro, Yuan, Jian-Min|||0000-0002-4620-3108, Zeggini, Eleftheria|||0000-0003-4238-659X, Zemel, Babette S., Zheng, Wei|||0000-0003-1226-070X, Zhu, X.|||0000-0003-0037-411X, Zmuda, Joseph M., Zonderman, Alan B.|||0000-0002-6523-4778, Zwart, John-Anker|||0000-0001-5721-0154, Croteau-Chonka, Damien, Vonk, Judith M., Le Marchand, Loic, Chasman, Daniel I.|||0000-0003-3357-0862, Cho, Yoon Shin, Heid, Iris M., McCarthy, Mark I., Ng, Maggie C. Y., O'Donnell, Christopher J., Rivadeneira, Fernando|||0000-0001-9435-9441, Thorsteinsdottir, Unnur, Sun, Yan V.|||0000-0002-2838-1824, Tai, E. Shyong, Boehnke, Michael|||0000-0002-6442-7754, Deloukas, Panos|||0000-0001-9251-070X, Justice, Anne E., Lindgren, Cecilia M., Loos, Ruth J. F.|||0000-0002-8532-5087, Mohlke, Karen L.|||0000-0001-6721-153X, North, Kari E., Stefánsson, Kári|||0000-0003-1676-864X, Walters, Robin G.|||0000-0002-9179-0321, Winkler, Thomas W.|||0000-0003-0292-5421, Young, Kristin L.|||0000-0003-0070-6145, Loh, Po-Ru, Yang, Jian|||0000-0003-4800-832X, Esko, Tõnu, Assimes, Themistocles|||0000-0003-2349-0009, Auton, Adam, Abecasis, Goncalo, Willer, Cristen J.|||0000-0001-5645-4966, Locke, Adam E.|||0000-0001-6227-198X, Berndt, Sonja, Lettre, Guillaume, Frayling, Timothy M., Okada, Yukinori|||0000-0002-0311-8472, Wood, Andrew R.|||0000-0003-1726-948X, Visscher, PM.|||0000-0002-2143-8760, Hirschhorn, Joel N.|||0000-0002-1650-7901
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:290601
Online Access:https://ddd.uab.cat/record/290601
https://dx.doi.org/urn:doi:10.1038/s41586-022-05275-y
Access Level:Open access
Keyword:Gene Frequency
Genome
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Description
Summary:Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.