Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients

Semen quality has a direct relation to male fertility. Whether sperm variables in humans have decreased over the last years is still uncertain, with some studies showing a decline and others reporting no changes. In this regard, previous research has suggested that lifestyle and environmental condit...

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Autores: Garcia-Grau, Emma, Lleberia, Judith, Costa Canals, Laura, Guitart, Miriam, Yeste Oliveras, Marc, Benet Buchholz, Jordi, Amengual Guedán, M. José, Ribas Maynou, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/22409
Acceso en línea:http://hdl.handle.net/10256/22409
Access Level:acceso abierto
Palabra clave:Semen
Reproducció humana
Esterilitat
Espermatozoides -- Motilitat
Human reproduction
Infertility
Spermatozoa -- Motility
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spelling Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patientsGarcia-Grau, EmmaLleberia, JudithCosta Canals, LauraGuitart, MiriamYeste Oliveras, MarcBenet Buchholz, JordiAmengual Guedán, M. JoséRibas Maynou, JordiSemenReproducció humanaEsterilitatEspermatozoides -- MotilitatSemenHuman reproductionInfertilitySpermatozoa -- MotilitySemen quality has a direct relation to male fertility. Whether sperm variables in humans have decreased over the last years is still uncertain, with some studies showing a decline and others reporting no changes. In this regard, previous research has suggested that lifestyle and environmental conditions may contribute to this variability, calling for regional studies. The present work is a retrospective, unicentric study that includes semen samples analyzed between 1997 and 2017 at the Parc Taulí Hospital (Barcelona metropolitan area). First, a multivariate analysis including the age as a confounding factor showed a statistically significant decrease in semen volume, pH, progressive motility, morphology and total motile sperm over time. Contrarily, no significant variation in sperm count or concentration was observed. Mean reductions per year were −0.02 mL for volume, −0.57% for progressively motile sperm and −0.72% for sperm with normal morphology. Interestingly, the average annual temperature registered by the Spanish Meteorology Agency negatively correlated to sperm morphology and sperm count (Rs = −0.642; p = 0.002 and Rs = −0.435; p = 0.049, respectively). In conclusion, the present study based on infertile patients from the Barcelona area found a decline in sperm motility and morphology, without effects on sperm count. Changes in temperature appeared to be associated to this decline, but further studies are needed to address the mechanisms linked to the observed variationsThe authors acknowledge the support of the European Union’s Horizon 2020 Research and Innovation scheme under the Marie Skłodowska-Curie grant agreement No. 801342 (Tecniospring INDUSTRY; TECSPR-19-1-0003), the Catalan Agency for Management of University and Research Grants, Regional Government of Catalonia, Spain (Grant: 2017-SGR-1229) and the Catalan Institution for Research and Advanced Studies (ICREA)MDPI (Multidisciplinary Digital Publishing Institute)2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/22409Biology, 2022, vol. 12, núm. 1, p. 70Articles publicats (D-B)Garcia-Grau, Emma Lleberia, Judith Costa, Laura Guitart, Miriam Yeste Oliveras, Marc Benet Buchholz, Jordi Amengual Guedán, M. José Ribas Maynou, Jordi 2022 Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients Biology 12 1 70reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.3390/biology12010070info:eu-repo/semantics/altIdentifier/eissn/2079-7737Attribution 4.0 International (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/224092026-05-29T05:05:01Z
dc.title.none.fl_str_mv Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
title Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
spellingShingle Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
Garcia-Grau, Emma
Semen
Reproducció humana
Esterilitat
Espermatozoides -- Motilitat
Semen
Human reproduction
Infertility
Spermatozoa -- Motility
title_short Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
title_full Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
title_fullStr Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
title_full_unstemmed Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
title_sort Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients
dc.creator.none.fl_str_mv Garcia-Grau, Emma
Lleberia, Judith
Costa Canals, Laura
Guitart, Miriam
Yeste Oliveras, Marc
Benet Buchholz, Jordi
Amengual Guedán, M. José
Ribas Maynou, Jordi
author Garcia-Grau, Emma
author_facet Garcia-Grau, Emma
Lleberia, Judith
Costa Canals, Laura
Guitart, Miriam
Yeste Oliveras, Marc
Benet Buchholz, Jordi
Amengual Guedán, M. José
Ribas Maynou, Jordi
author_role author
author2 Lleberia, Judith
Costa Canals, Laura
Guitart, Miriam
Yeste Oliveras, Marc
Benet Buchholz, Jordi
Amengual Guedán, M. José
Ribas Maynou, Jordi
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Semen
Reproducció humana
Esterilitat
Espermatozoides -- Motilitat
Semen
Human reproduction
Infertility
Spermatozoa -- Motility
topic Semen
Reproducció humana
Esterilitat
Espermatozoides -- Motilitat
Semen
Human reproduction
Infertility
Spermatozoa -- Motility
description Semen quality has a direct relation to male fertility. Whether sperm variables in humans have decreased over the last years is still uncertain, with some studies showing a decline and others reporting no changes. In this regard, previous research has suggested that lifestyle and environmental conditions may contribute to this variability, calling for regional studies. The present work is a retrospective, unicentric study that includes semen samples analyzed between 1997 and 2017 at the Parc Taulí Hospital (Barcelona metropolitan area). First, a multivariate analysis including the age as a confounding factor showed a statistically significant decrease in semen volume, pH, progressive motility, morphology and total motile sperm over time. Contrarily, no significant variation in sperm count or concentration was observed. Mean reductions per year were −0.02 mL for volume, −0.57% for progressively motile sperm and −0.72% for sperm with normal morphology. Interestingly, the average annual temperature registered by the Spanish Meteorology Agency negatively correlated to sperm morphology and sperm count (Rs = −0.642; p = 0.002 and Rs = −0.435; p = 0.049, respectively). In conclusion, the present study based on infertile patients from the Barcelona area found a decline in sperm motility and morphology, without effects on sperm count. Changes in temperature appeared to be associated to this decline, but further studies are needed to address the mechanisms linked to the observed variations
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/22409
url http://hdl.handle.net/10256/22409
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/biology12010070
info:eu-repo/semantics/altIdentifier/eissn/2079-7737
dc.rights.none.fl_str_mv Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI (Multidisciplinary Digital Publishing Institute)
publisher.none.fl_str_mv MDPI (Multidisciplinary Digital Publishing Institute)
dc.source.none.fl_str_mv Biology, 2022, vol. 12, núm. 1, p. 70
Articles publicats (D-B)
Garcia-Grau, Emma Lleberia, Judith Costa, Laura Guitart, Miriam Yeste Oliveras, Marc Benet Buchholz, Jordi Amengual Guedán, M. José Ribas Maynou, Jordi 2022 Decline of sperm quality over the last two decades in the south of Europe: a retrospective study in infertile patients Biology 12 1 70
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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