Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths

Electrical forces are the background of all the interactions occurring in biochemical systems. From here and by using a combination of ab-initio and ad-hoc models, we introduce the first description of electric field profiles with intrabond resolution to support a characterization of single bond for...

Descripción completa

Detalles Bibliográficos
Autores: Ruiz Blanco, Yasser B., Almeida, Y., Sotomayor Torres, Clivia M.|||0000-0001-9986-2716, García, Yamila
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:204853
Acceso en línea:https://ddd.uab.cat/record/204853
https://dx.doi.org/urn:doi:10.1371/journal.pone.0185638
Access Level:acceso abierto
Palabra clave:Base Pairing
DNA
Hydrogen Bonding
Nucleic Acid Conformation
id ES_b9cb2b05cd1f2be4c9f0565eac0f8eb9
oai_identifier_str oai:ddd.uab.cat:204853
network_acronym_str ES
network_name_str España
repository_id_str
spelling Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengthsRuiz Blanco, Yasser B.Almeida, Y.Sotomayor Torres, Clivia M.|||0000-0001-9986-2716García, YamilaBase PairingDNAHydrogen BondingNucleic Acid ConformationElectrical forces are the background of all the interactions occurring in biochemical systems. From here and by using a combination of ab-initio and ad-hoc models, we introduce the first description of electric field profiles with intrabond resolution to support a characterization of single bond forces attending to its electrical origin. This fundamental issue has eluded a physical description so far. Our method is applied to describe hydrogen bonds (HB) in DNA base pairs. Numerical results reveal that base pairs in DNA could be equivalent considering HB strength contributions, which challenges previous interpretations of thermodynamic properties of DNA based on the assumption that Adenine/Thymine pairs are weaker than Guanine/Cytosine pairs due to the sole difference in the number of HB. Thus, our methodology provides solid foundations to support the development of extended models intended to go deeper into the molecular mechanisms of DNA functioning. 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/204853https://dx.doi.org/urn:doi:10.1371/journal.pone.0185638reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 FIS2015-70862PMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2013-0295open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2048532026-06-06T12:50:31Z
dc.title.none.fl_str_mv Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
title Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
spellingShingle Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
Ruiz Blanco, Yasser B.
Base Pairing
DNA
Hydrogen Bonding
Nucleic Acid Conformation
title_short Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
title_full Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
title_fullStr Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
title_full_unstemmed Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
title_sort Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
dc.creator.none.fl_str_mv Ruiz Blanco, Yasser B.
Almeida, Y.
Sotomayor Torres, Clivia M.|||0000-0001-9986-2716
García, Yamila
author Ruiz Blanco, Yasser B.
author_facet Ruiz Blanco, Yasser B.
Almeida, Y.
Sotomayor Torres, Clivia M.|||0000-0001-9986-2716
García, Yamila
author_role author
author2 Almeida, Y.
Sotomayor Torres, Clivia M.|||0000-0001-9986-2716
García, Yamila
author2_role author
author
author
dc.subject.none.fl_str_mv Base Pairing
DNA
Hydrogen Bonding
Nucleic Acid Conformation
topic Base Pairing
DNA
Hydrogen Bonding
Nucleic Acid Conformation
description Electrical forces are the background of all the interactions occurring in biochemical systems. From here and by using a combination of ab-initio and ad-hoc models, we introduce the first description of electric field profiles with intrabond resolution to support a characterization of single bond forces attending to its electrical origin. This fundamental issue has eluded a physical description so far. Our method is applied to describe hydrogen bonds (HB) in DNA base pairs. Numerical results reveal that base pairs in DNA could be equivalent considering HB strength contributions, which challenges previous interpretations of thermodynamic properties of DNA based on the assumption that Adenine/Thymine pairs are weaker than Guanine/Cytosine pairs due to the sole difference in the number of HB. Thus, our methodology provides solid foundations to support the development of extended models intended to go deeper into the molecular mechanisms of DNA functioning.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/204853
https://dx.doi.org/urn:doi:10.1371/journal.pone.0185638
url https://ddd.uab.cat/record/204853
https://dx.doi.org/urn:doi:10.1371/journal.pone.0185638
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 FIS2015-70862P
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2013-0295
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417803049598976
score 15.300719

Similares en LA Referencia