A brain-accessible peptide modulates stroke inflammatory response and neurotoxicity by targeting BDNF-receptor TrkB-T1 specific interactome

[Methods]: We designed cell-penetrating peptides containing TrkB-T1 isoform-specific sequences to: 1) characterize peptide delivery into rat primary cortical cultures and mice brain cortex; 2) isolate and identify the isoform interactome in basal and in vitro excitotoxic conditions; 3) analyze pepti...

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Detalhes bibliográficos
Autores: Ugalde-Triviño, Lola, Tejeda, Gonzalo S., Esteban-Ortega, Gema M., Díaz-Guerra, Margarita
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/412350
Acesso em linha:http://hdl.handle.net/10261/412350
Access Level:acceso abierto
Palavra-chave:Cell-penetrating peptides
Excitotoxicity
Inflammatory response
Interactome
Neurodegeneration
Neuroprotection
Descrição
Resumo:[Methods]: We designed cell-penetrating peptides containing TrkB-T1 isoform-specific sequences to: 1) characterize peptide delivery into rat primary cortical cultures and mice brain cortex; 2) isolate and identify the isoform interactome in basal and in vitro excitotoxic conditions; 3) analyze peptide effects on neuroinflammation and neurotoxicity using primary cultures subjected to excitotoxicity or in vivo in a mouse model of ischemia.

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