The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)
Introduction: Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/225042 |
| Acceso en línea: | https://hdl.handle.net/2445/225042 |
| Access Level: | acceso abierto |
| Palabra clave: | Bacteris gramnegatius Escheríchia coli Klebsiella pneumoniae Gram-negative bacteria Escherichia coli |
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The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)Gracia Ahufinger, IreneLópez-González, LauraVasallo, FranciscoGalar, AliciaSiller, MaríaPitart, CristinaBloise, IvánTorrecillas, MiriamGijón Cordero, DesiréeViñado Pérez, BelenCastillo-García, JavierCampo, RainerMulet, XavierMadueño-Alonso, AnaChamizo-López, Francisco JavierArrastia-Erviti, MatianeGalán-Sánchez, FátimaFernández-Quejo, MelisaRodríguez-Díaz, Juan CarlosGutiérrez-Zufiaurre, María NievesRodríguez-Maresca, Manuel AngelOrtega-Lafont, María del PilarYagüe Guirao, GenovevaChaves-Blanco, LucíaColomina-Rodríguez, JavierVidal-Acuña, María ReyesPortillo, María EugeniaFranco-Álvarez de Luna, FranciscoCentelles-Serrano, María JoséAzcona-Gutiérrez, José ManuelDelgado-Iribarren García Campero, AlbertoRey-Cao, SoniaMuñoz, PatriciaCalvo Montes, JorgeZboromyrska, YuliyaGrandioso, DavidCàmara Mas, Jordi Cantón, RafaelLarrosa-Escartín, NievesDíaz Regañón, JazmínMartínez-Martínez, LuisBacteris gramnegatiusEscheríchia coliKlebsiella pneumoniaeGram-negative bacteriaEscherichia coliKlebsiella pneumoniaeIntroduction: Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018. Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0. Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017-2018 compared to 2014-2016. Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms.Frontiers Media2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/225042Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fmicb.2023.1247804Frontiers in Microbiology, 2023, vol. 14https://doi.org/10.3389/fmicb.2023.1247804cc-by (c) Gracia-Ahufinger, I. et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2250422026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) |
| title |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) |
| spellingShingle |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) Gracia Ahufinger, Irene Bacteris gramnegatius Escheríchia coli Klebsiella pneumoniae Gram-negative bacteria Escherichia coli Klebsiella pneumoniae |
| title_short |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) |
| title_full |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) |
| title_fullStr |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) |
| title_full_unstemmed |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) |
| title_sort |
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) |
| dc.creator.none.fl_str_mv |
Gracia Ahufinger, Irene López-González, Laura Vasallo, Francisco Galar, Alicia Siller, María Pitart, Cristina Bloise, Iván Torrecillas, Miriam Gijón Cordero, Desirée Viñado Pérez, Belen Castillo-García, Javier Campo, Rainer Mulet, Xavier Madueño-Alonso, Ana Chamizo-López, Francisco Javier Arrastia-Erviti, Matiane Galán-Sánchez, Fátima Fernández-Quejo, Melisa Rodríguez-Díaz, Juan Carlos Gutiérrez-Zufiaurre, María Nieves Rodríguez-Maresca, Manuel Angel Ortega-Lafont, María del Pilar Yagüe Guirao, Genoveva Chaves-Blanco, Lucía Colomina-Rodríguez, Javier Vidal-Acuña, María Reyes Portillo, María Eugenia Franco-Álvarez de Luna, Francisco Centelles-Serrano, María José Azcona-Gutiérrez, José Manuel Delgado-Iribarren García Campero, Alberto Rey-Cao, Sonia Muñoz, Patricia Calvo Montes, Jorge Zboromyrska, Yuliya Grandioso, David Càmara Mas, Jordi Cantón, Rafael Larrosa-Escartín, Nieves Díaz Regañón, Jazmín Martínez-Martínez, Luis |
| author |
Gracia Ahufinger, Irene |
| author_facet |
Gracia Ahufinger, Irene López-González, Laura Vasallo, Francisco Galar, Alicia Siller, María Pitart, Cristina Bloise, Iván Torrecillas, Miriam Gijón Cordero, Desirée Viñado Pérez, Belen Castillo-García, Javier Campo, Rainer Mulet, Xavier Madueño-Alonso, Ana Chamizo-López, Francisco Javier Arrastia-Erviti, Matiane Galán-Sánchez, Fátima Fernández-Quejo, Melisa Rodríguez-Díaz, Juan Carlos Gutiérrez-Zufiaurre, María Nieves Rodríguez-Maresca, Manuel Angel Ortega-Lafont, María del Pilar Yagüe Guirao, Genoveva Chaves-Blanco, Lucía Colomina-Rodríguez, Javier Vidal-Acuña, María Reyes Portillo, María Eugenia Franco-Álvarez de Luna, Francisco Centelles-Serrano, María José Azcona-Gutiérrez, José Manuel Delgado-Iribarren García Campero, Alberto Rey-Cao, Sonia Muñoz, Patricia Calvo Montes, Jorge Zboromyrska, Yuliya Grandioso, David Càmara Mas, Jordi Cantón, Rafael Larrosa-Escartín, Nieves Díaz Regañón, Jazmín Martínez-Martínez, Luis |
| author_role |
author |
| author2 |
López-González, Laura Vasallo, Francisco Galar, Alicia Siller, María Pitart, Cristina Bloise, Iván Torrecillas, Miriam Gijón Cordero, Desirée Viñado Pérez, Belen Castillo-García, Javier Campo, Rainer Mulet, Xavier Madueño-Alonso, Ana Chamizo-López, Francisco Javier Arrastia-Erviti, Matiane Galán-Sánchez, Fátima Fernández-Quejo, Melisa Rodríguez-Díaz, Juan Carlos Gutiérrez-Zufiaurre, María Nieves Rodríguez-Maresca, Manuel Angel Ortega-Lafont, María del Pilar Yagüe Guirao, Genoveva Chaves-Blanco, Lucía Colomina-Rodríguez, Javier Vidal-Acuña, María Reyes Portillo, María Eugenia Franco-Álvarez de Luna, Francisco Centelles-Serrano, María José Azcona-Gutiérrez, José Manuel Delgado-Iribarren García Campero, Alberto Rey-Cao, Sonia Muñoz, Patricia Calvo Montes, Jorge Zboromyrska, Yuliya Grandioso, David Càmara Mas, Jordi Cantón, Rafael Larrosa-Escartín, Nieves Díaz Regañón, Jazmín Martínez-Martínez, Luis |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Bacteris gramnegatius Escheríchia coli Klebsiella pneumoniae Gram-negative bacteria Escherichia coli Klebsiella pneumoniae |
| topic |
Bacteris gramnegatius Escheríchia coli Klebsiella pneumoniae Gram-negative bacteria Escherichia coli Klebsiella pneumoniae |
| description |
Introduction: Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018. Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0. Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017-2018 compared to 2014-2016. Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/225042 |
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https://hdl.handle.net/2445/225042 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2023.1247804 Frontiers in Microbiology, 2023, vol. 14 https://doi.org/10.3389/fmicb.2023.1247804 |
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cc-by (c) Gracia-Ahufinger, I. et al., 2023 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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cc-by (c) Gracia-Ahufinger, I. et al., 2023 http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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Articles publicats en revistes (Fonaments Clínics) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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