Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence

The house sparrow (Passer domesticus) is a globally distributed species found in rural, urban and other humanised environments. In Europe, sparrow populations have significantly declined in recent decades, especially in urbanised areas. In the present study, we analysed the impact of urbanization on...

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Autores: Minayo Martín, Sara, Villar, Margarita, Sánchez-Cano, Alberto, Fontoura-Gonçalves, Catarina, Hernández, José Manuel, Williams, Richard A. J., Quevedo-Muñoz, Miguel Ángel, Höfle, Ursula
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/392348
Acesso em linha:http://hdl.handle.net/10261/392348
Access Level:Acceso aberto
Palavra-chave:Passer domesticus
Urbanization
Serum proteome
Avian malaria
Avian influenza
Flavivirus
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spelling Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalenceMinayo Martín, SaraVillar, MargaritaSánchez-Cano, AlbertoFontoura-Gonçalves, CatarinaHernández, José ManuelWilliams, Richard A. J.Quevedo-Muñoz, Miguel ÁngelHöfle, UrsulaPasser domesticusUrbanizationSerum proteomeAvian malariaAvian influenzaFlavivirusThe house sparrow (Passer domesticus) is a globally distributed species found in rural, urban and other humanised environments. In Europe, sparrow populations have significantly declined in recent decades, especially in urbanised areas. In the present study, we analysed the impact of urbanization on sparrow body condition, pathogen prevalence, and serum proteome changes. Sparrows were captured in four locations with two different urbanization status (rural/urban). Biometric data, blood samples and oral and cloacal swabs were collected. Rural sparrows exhibited significantly better body condition compared to urban sparrows, with no notable differences between sexes. Haemoparasite prevalence was higher in rural sparrows 70.16 % (87/124) than in urban sparrows 50 % (27/54). No avian influenza virus (AIV) or West Nile virus (WNV) genetic material was found, although one urban sparrow (0.58 %) had antibodies to AIV. Serum proteomics revealed that rural sparrows showed an up-regulation of proteins involved in the metabolism, in contrast to proteins of the immune system and the coagulation system, which were found to be over-represented in urban sparrows. Thus, we documented a worse body condition and immune system activation in urban sparrows in contrast to a more active metabolism and a higher prevalence of avian malaria in rural sparrows, and at least occasional exposure to AIV in urban habitats. This information suggests exposure to urban environments may alter the host-pathogen relationship. Urbanization in combination with exposure to AIV, could modulate their role in viral spread and transmission.This study is part of the INFLUOMA project funded by grant PID2020-114060RR-C32 MICIU/AEI/ 10.13039/501100011033 and 2022-GRIN-34227 grant, funded by the University of Castilla-La Mancha and FEDER. Sara Minayo Martín is a beneficiariy of INVESTIGO contract 1769562055/ 2022-INVGO-12. Protein Identification and quantification by LC-MS/MS was carried out in the ‘CBMSO PROTEIN CHEMISTRY FACILITY’, belonging to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019, of the PE I+D+i 2013-2016, funded by ISCIII and ERDF.Peer reviewedElsevierAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Universidad de Castilla La ManchaEuropean CommissionInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/392348reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114060RR-C32The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.scitotenv.2025.178920https://doi.org/10.1016/j.scitotenv.2025.178920Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3923482026-05-22T06:33:51Z
dc.title.none.fl_str_mv Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
title Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
spellingShingle Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
Minayo Martín, Sara
Passer domesticus
Urbanization
Serum proteome
Avian malaria
Avian influenza
Flavivirus
title_short Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
title_full Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
title_fullStr Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
title_full_unstemmed Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
title_sort Impact of urbanization on the house sparrow (Passer domesticus): Serum proteome and pathogen prevalence
dc.creator.none.fl_str_mv Minayo Martín, Sara
Villar, Margarita
Sánchez-Cano, Alberto
Fontoura-Gonçalves, Catarina
Hernández, José Manuel
Williams, Richard A. J.
Quevedo-Muñoz, Miguel Ángel
Höfle, Ursula
author Minayo Martín, Sara
author_facet Minayo Martín, Sara
Villar, Margarita
Sánchez-Cano, Alberto
Fontoura-Gonçalves, Catarina
Hernández, José Manuel
Williams, Richard A. J.
Quevedo-Muñoz, Miguel Ángel
Höfle, Ursula
author_role author
author2 Villar, Margarita
Sánchez-Cano, Alberto
Fontoura-Gonçalves, Catarina
Hernández, José Manuel
Williams, Richard A. J.
Quevedo-Muñoz, Miguel Ángel
Höfle, Ursula
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Universidad de Castilla La Mancha
European Commission
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Passer domesticus
Urbanization
Serum proteome
Avian malaria
Avian influenza
Flavivirus
topic Passer domesticus
Urbanization
Serum proteome
Avian malaria
Avian influenza
Flavivirus
description The house sparrow (Passer domesticus) is a globally distributed species found in rural, urban and other humanised environments. In Europe, sparrow populations have significantly declined in recent decades, especially in urbanised areas. In the present study, we analysed the impact of urbanization on sparrow body condition, pathogen prevalence, and serum proteome changes. Sparrows were captured in four locations with two different urbanization status (rural/urban). Biometric data, blood samples and oral and cloacal swabs were collected. Rural sparrows exhibited significantly better body condition compared to urban sparrows, with no notable differences between sexes. Haemoparasite prevalence was higher in rural sparrows 70.16 % (87/124) than in urban sparrows 50 % (27/54). No avian influenza virus (AIV) or West Nile virus (WNV) genetic material was found, although one urban sparrow (0.58 %) had antibodies to AIV. Serum proteomics revealed that rural sparrows showed an up-regulation of proteins involved in the metabolism, in contrast to proteins of the immune system and the coagulation system, which were found to be over-represented in urban sparrows. Thus, we documented a worse body condition and immune system activation in urban sparrows in contrast to a more active metabolism and a higher prevalence of avian malaria in rural sparrows, and at least occasional exposure to AIV in urban habitats. This information suggests exposure to urban environments may alter the host-pathogen relationship. Urbanization in combination with exposure to AIV, could modulate their role in viral spread and transmission.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/392348
url http://hdl.handle.net/10261/392348
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114060RR-C32
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.scitotenv.2025.178920
https://doi.org/10.1016/j.scitotenv.2025.178920
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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