Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma

Multiple myeloma (MM) remains an incurable plasma cell malignancy. While its origin is enigmatic, an association with infectious pathogens including hepatitis C virus (HCV) has been suggested. Here we report nine patients with monoclonal gammopathy of undetermined significance (MGUS) or MM with prev...

Descripción completa

Detalles Bibliográficos
Autores: Rodríguez-García, Alba, Linares Gómez, María, Morales, María Luz, Allain-Maillet, Sophie, Mennesson, Nicolas, Sánchez, Ricardo, Alonso, Rafael, Leivas, Alejandra, Pérez Rivilla, José Alfredo, Bigot-Corbel, Edith, Hermouet, Sylvie, Martínez López, Joaquín
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/101687
Acceso en línea:https://hdl.handle.net/20.500.14352/101687
Access Level:acceso abierto
Palabra clave:577.1
Infection
Hepatitis (C) virus
Monoclonal gammopathies
Multiple myeloma
Antiviral
Ciencias Biomédicas
Bioquímica (Farmacia)
24 Ciencias de la Vida
id ES_b97228f6df1952fcfa48efe2ed0c3cc4
oai_identifier_str oai:docta.ucm.es:20.500.14352/101687
network_acronym_str ES
network_name_str España
repository_id_str
spelling Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including MyelomaRodríguez-García, AlbaLinares Gómez, MaríaMorales, María LuzAllain-Maillet, SophieMennesson, NicolasSánchez, RicardoAlonso, RafaelLeivas, AlejandraPérez Rivilla, José AlfredoBigot-Corbel, EdithHermouet, SylvieMartínez López, Joaquín577.1InfectionHepatitis (C) virusMonoclonal gammopathiesMultiple myelomaAntiviralCiencias BiomédicasBioquímica (Farmacia)24 Ciencias de la VidaMultiple myeloma (MM) remains an incurable plasma cell malignancy. While its origin is enigmatic, an association with infectious pathogens including hepatitis C virus (HCV) has been suggested. Here we report nine patients with monoclonal gammopathy of undetermined significance (MGUS) or MM with previous HCV infection, six of whom received antiviral treatment. We studied the evolution of the gammopathy disease, according to anti-HCV treatment and antigen specificity of purified monoclonal immunoglobulin, determined using the INNO-LIA™ HCV Score assay, dot-blot assays, and a multiplex infectious antigen microarray. The monoclonal immunoglobulin from 6/9 patients reacted against HCV. Four of these patients received antiviral treatment and had a better evolution than untreated patients. Following antiviral treatment, one patient with MM in third relapse achieved complete remission with minimal residual disease negativity. For two patients who did not receive antiviral treatment, disease progressed. For the two patients whose monoclonal immunoglobulin did not react against HCV, antiviral treatment was not effective for MGUS or MM disease. Our results suggest a causal relationship between HCV infection and MGUS and MM progression. When HCV was eliminated, chronic antigen-stimulation disappeared, allowing control of clonal plasma cells. This opens new possibilities of treatment for MGUS and myeloma.Universidad Complutense de Madrid20222022-01-1120222022-01-11journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/101687reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1016872026-06-02T12:44:21Z
dc.title.none.fl_str_mv Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
title Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
spellingShingle Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
Rodríguez-García, Alba
577.1
Infection
Hepatitis (C) virus
Monoclonal gammopathies
Multiple myeloma
Antiviral
Ciencias Biomédicas
Bioquímica (Farmacia)
24 Ciencias de la Vida
title_short Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
title_full Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
title_fullStr Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
title_full_unstemmed Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
title_sort Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
dc.creator.none.fl_str_mv Rodríguez-García, Alba
Linares Gómez, María
Morales, María Luz
Allain-Maillet, Sophie
Mennesson, Nicolas
Sánchez, Ricardo
Alonso, Rafael
Leivas, Alejandra
Pérez Rivilla, José Alfredo
Bigot-Corbel, Edith
Hermouet, Sylvie
Martínez López, Joaquín
author Rodríguez-García, Alba
author_facet Rodríguez-García, Alba
Linares Gómez, María
Morales, María Luz
Allain-Maillet, Sophie
Mennesson, Nicolas
Sánchez, Ricardo
Alonso, Rafael
Leivas, Alejandra
Pérez Rivilla, José Alfredo
Bigot-Corbel, Edith
Hermouet, Sylvie
Martínez López, Joaquín
author_role author
author2 Linares Gómez, María
Morales, María Luz
Allain-Maillet, Sophie
Mennesson, Nicolas
Sánchez, Ricardo
Alonso, Rafael
Leivas, Alejandra
Pérez Rivilla, José Alfredo
Bigot-Corbel, Edith
Hermouet, Sylvie
Martínez López, Joaquín
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.1
Infection
Hepatitis (C) virus
Monoclonal gammopathies
Multiple myeloma
Antiviral
Ciencias Biomédicas
Bioquímica (Farmacia)
24 Ciencias de la Vida
topic 577.1
Infection
Hepatitis (C) virus
Monoclonal gammopathies
Multiple myeloma
Antiviral
Ciencias Biomédicas
Bioquímica (Farmacia)
24 Ciencias de la Vida
description Multiple myeloma (MM) remains an incurable plasma cell malignancy. While its origin is enigmatic, an association with infectious pathogens including hepatitis C virus (HCV) has been suggested. Here we report nine patients with monoclonal gammopathy of undetermined significance (MGUS) or MM with previous HCV infection, six of whom received antiviral treatment. We studied the evolution of the gammopathy disease, according to anti-HCV treatment and antigen specificity of purified monoclonal immunoglobulin, determined using the INNO-LIA™ HCV Score assay, dot-blot assays, and a multiplex infectious antigen microarray. The monoclonal immunoglobulin from 6/9 patients reacted against HCV. Four of these patients received antiviral treatment and had a better evolution than untreated patients. Following antiviral treatment, one patient with MM in third relapse achieved complete remission with minimal residual disease negativity. For two patients who did not receive antiviral treatment, disease progressed. For the two patients whose monoclonal immunoglobulin did not react against HCV, antiviral treatment was not effective for MGUS or MM disease. Our results suggest a causal relationship between HCV infection and MGUS and MM progression. When HCV was eliminated, chronic antigen-stimulation disappeared, allowing control of clonal plasma cells. This opens new possibilities of treatment for MGUS and myeloma.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-11
2022
2022-01-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/101687
url https://hdl.handle.net/20.500.14352/101687
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417773578321920
score 15,300719

Similares en LA Referencia