Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands
A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosph...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/102067 |
| Acceso en línea: | https://hdl.handle.net/2445/102067 |
| Access Level: | acceso abierto |
| Palabra clave: | Compostos fosforosos Lligands (Bioquímica) Phosphorus compounds Ligands (Biochemistry) |
| Sumario: | A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosphine. The process is based on the redn. of a mixed anhydride, the configurational stability of which has been studied in several solvents and temps. Tetrabutylammonium borohydride was the best reducing agent allowing for the development of a practical process. To demonstrate the utility of the new methodol., the product obtained in this manner was used in the prepn. of Quinox-P*. |
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