Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol

Background Psychotherapy for Prolonged Grief Disorder (PGD), a condition characterized by an intense and persistent grief response, has received increased attention over the past decades. Evidence-based approaches to prevent PGD are currently scarce, and not always effective. This paper introduces a...

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Autores: Sabucedo P, Andión O, Neimeyer RA, Soto-Angona O, Javkin J, Haro JM, Farré M, González D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p27422
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27422
Access Level:acceso abierto
Palabra clave:psychedelic-assisted therapy
ayahuasca
psychedelics
meaning reconstruction
psychotherapy
protocol
bereavement
prolonged grief disorder
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spelling Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocolSabucedo PAndión ONeimeyer RASoto-Angona OJavkin JHaro JMFarré MGonzález Dpsychedelic-assisted therapyayahuascapsychedelicsmeaning reconstructionpsychotherapyprotocolbereavementprolonged grief disorderBackground Psychotherapy for Prolonged Grief Disorder (PGD), a condition characterized by an intense and persistent grief response, has received increased attention over the past decades. Evidence-based approaches to prevent PGD are currently scarce, and not always effective. This paper introduces a protocol for a clinical trial exploring the effectiveness of a Meaning Reconstruction psychotherapy approach (MR) assisted with ayahuasca, a traditional indigenous medicine. Method The outlined protocol is a three-arm, non-randomized controlled trial focused on reducing normal and pathological grief symptoms, comparing the effectiveness of Ayahuasca-assisted MR therapy (A-MR), MR therapy alone (MR) and No Treatment (NT). At least 69 people who lost a first-degree relative during the prior year, and with a Texas Revised Inventory of Grief score up 39 (TRIG >= 40), will participate in the trial. Participants will be allocated to an A-MR (n >= 23), MR (n >= 23) or NT (n >= 23) group. Those from the A-MR and MR therapy groups will undergo a therapeutic process involving 9 sessions of online psychotherapy. In addition, the A-MR condition involves 2 group sessions of ayahuasca. The primary outcomes will be normal and pathological grief severity as measured by the TRIG and Traumatic Grief Inventory Self-Report (TGI-SR), administered at baseline, post-treatment, and 3-month follow up. Measures of quality of life, post-traumatic growth, meaning-made, psychological flexibility, and self-belief consistency will be also included. In addition, subjective effects of ayahuasca and acceptance-avoidance promoting effects will be assessed following ayahuasca administration. Finally, we will analyze the potential mediating effect of meaning-made, psychological flexibility and self-belief consistency in grief symptoms (as measured by the TRIG and TGI). Discussion This trial is the first to empirically examinate the potential of psychedelic-assisted psychotherapy for grief, as well as the potential processes of change that may account for it. Clinical trial registration https://clinicaltrials.gov, identifier NCT06150859.FRONTIERS MEDIA SA2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27422Frontiers in PsychiatryISSN: 16640640reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p274222026-05-27T12:37:41Z
dc.title.none.fl_str_mv Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
title Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
spellingShingle Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
Sabucedo P
psychedelic-assisted therapy
ayahuasca
psychedelics
meaning reconstruction
psychotherapy
protocol
bereavement
prolonged grief disorder
title_short Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
title_full Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
title_fullStr Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
title_full_unstemmed Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
title_sort Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol
dc.creator.none.fl_str_mv Sabucedo P
Andión O
Neimeyer RA
Soto-Angona O
Javkin J
Haro JM
Farré M
González D
author Sabucedo P
author_facet Sabucedo P
Andión O
Neimeyer RA
Soto-Angona O
Javkin J
Haro JM
Farré M
González D
author_role author
author2 Andión O
Neimeyer RA
Soto-Angona O
Javkin J
Haro JM
Farré M
González D
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv psychedelic-assisted therapy
ayahuasca
psychedelics
meaning reconstruction
psychotherapy
protocol
bereavement
prolonged grief disorder
topic psychedelic-assisted therapy
ayahuasca
psychedelics
meaning reconstruction
psychotherapy
protocol
bereavement
prolonged grief disorder
description Background Psychotherapy for Prolonged Grief Disorder (PGD), a condition characterized by an intense and persistent grief response, has received increased attention over the past decades. Evidence-based approaches to prevent PGD are currently scarce, and not always effective. This paper introduces a protocol for a clinical trial exploring the effectiveness of a Meaning Reconstruction psychotherapy approach (MR) assisted with ayahuasca, a traditional indigenous medicine. Method The outlined protocol is a three-arm, non-randomized controlled trial focused on reducing normal and pathological grief symptoms, comparing the effectiveness of Ayahuasca-assisted MR therapy (A-MR), MR therapy alone (MR) and No Treatment (NT). At least 69 people who lost a first-degree relative during the prior year, and with a Texas Revised Inventory of Grief score up 39 (TRIG >= 40), will participate in the trial. Participants will be allocated to an A-MR (n >= 23), MR (n >= 23) or NT (n >= 23) group. Those from the A-MR and MR therapy groups will undergo a therapeutic process involving 9 sessions of online psychotherapy. In addition, the A-MR condition involves 2 group sessions of ayahuasca. The primary outcomes will be normal and pathological grief severity as measured by the TRIG and Traumatic Grief Inventory Self-Report (TGI-SR), administered at baseline, post-treatment, and 3-month follow up. Measures of quality of life, post-traumatic growth, meaning-made, psychological flexibility, and self-belief consistency will be also included. In addition, subjective effects of ayahuasca and acceptance-avoidance promoting effects will be assessed following ayahuasca administration. Finally, we will analyze the potential mediating effect of meaning-made, psychological flexibility and self-belief consistency in grief symptoms (as measured by the TRIG and TGI). Discussion This trial is the first to empirically examinate the potential of psychedelic-assisted psychotherapy for grief, as well as the potential processes of change that may account for it. Clinical trial registration https://clinicaltrials.gov, identifier NCT06150859.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27422
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27422
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Psychiatry
ISSN: 16640640
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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