Septal curvature as a robust and reproducible marker for basal septal hypertrophy
Background: Basal septal hypertrophy (BSH) is an asymmetric, localized thickening of the upper interventricular septum and constitutes a marker of an early remodelling in patients with hypertension. This morphological trait has been extensively researched because of its prevalence in hypertension, y...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/71561 |
| Acceso en línea: | http://hdl.handle.net/10230/71561 http://dx.doi.org/10.1097/HJH.0000000000002813 |
| Access Level: | acceso abierto |
| Palabra clave: | Basic research Curvature Diastolic function Hypertension Hypertrophy Systolic function |
| id |
ES_b91fb04ca2d883c88ae5050558cd03b3 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:10230/71561 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Septal curvature as a robust and reproducible marker for basal septal hypertrophyMarciniak, MaciejGilbert, AndrewLoncaric, FilipFernandes, João, 1964-Bijnens, BartSitges, MartaKing, AndrewCrispi Brillas, FàtimaLamata, PabloBasic researchCurvatureDiastolic functionHypertensionHypertrophySystolic functionBackground: Basal septal hypertrophy (BSH) is an asymmetric, localized thickening of the upper interventricular septum and constitutes a marker of an early remodelling in patients with hypertension. This morphological trait has been extensively researched because of its prevalence in hypertension, yet its clinical and prognostic value for individual patients remains undetermined. One of the reasons is the lack of a reliable and reproducible metric to quantify the presence and the extent of BSH. This article proposes the use of the curvature of the left ventricular endocardium as a robust feature for BSH characterization, and as an objective criterion to quantify current subjective ‘visual assessment’ of the presence of sigmoidal septum. The proposed marker, called average septal curvature, is defined as the inverse of the radius adjacent to each point of the endocardial contour along the basal and mid inferoseptal segments of the left ventricle. Method: Robustness and reproducibility were assessed on a cohort of 220 patients, including 161 hypertensive patients (32 with BSH) and 59 healthy controls. Results: The results show that compared with the conventionally used wall thickness metrics, the new marker is more reproducible (relative standard deviation of errors of 7 vs. 13%, and 8 vs. 38% for intra-observer and inter-observer variability, respectively) and better correlates to the functional parameters related to BSH, with main difference (absolute rank correlation 0.417 vs. 0.341) in local deformation changes assessed by longitudinal strain. Conclusion: Average septal curvature is a more precisely defined and reproducible metric than thickness ratios, it can be fully automated, and better infers the functional remodelling related to hypertension.This project has received funding from the European Union's Horizon 2020 Research and Innovation programme under the Marie Skłodowska-Curie grant agreement No 764738. P.L. holds a Wellcome Trust Senior Research Fellowship (209450/Z/17/Z).Wolters Kluwer202520252021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/71561http://dx.doi.org/10.1097/HJH.0000000000002813http://hdl.handle.net/10230/71561reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Hypertension. 2021 Jul;39(7):1421-8info:eu-repo/grantAgreement/EC/H2020/764738This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10230/715612026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy |
| title |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy |
| spellingShingle |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy Marciniak, Maciej Basic research Curvature Diastolic function Hypertension Hypertrophy Systolic function |
| title_short |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy |
| title_full |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy |
| title_fullStr |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy |
| title_full_unstemmed |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy |
| title_sort |
Septal curvature as a robust and reproducible marker for basal septal hypertrophy |
| dc.creator.none.fl_str_mv |
Marciniak, Maciej Gilbert, Andrew Loncaric, Filip Fernandes, João, 1964- Bijnens, Bart Sitges, Marta King, Andrew Crispi Brillas, Fàtima Lamata, Pablo |
| author |
Marciniak, Maciej |
| author_facet |
Marciniak, Maciej Gilbert, Andrew Loncaric, Filip Fernandes, João, 1964- Bijnens, Bart Sitges, Marta King, Andrew Crispi Brillas, Fàtima Lamata, Pablo |
| author_role |
author |
| author2 |
Gilbert, Andrew Loncaric, Filip Fernandes, João, 1964- Bijnens, Bart Sitges, Marta King, Andrew Crispi Brillas, Fàtima Lamata, Pablo |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Basic research Curvature Diastolic function Hypertension Hypertrophy Systolic function |
| topic |
Basic research Curvature Diastolic function Hypertension Hypertrophy Systolic function |
| description |
Background: Basal septal hypertrophy (BSH) is an asymmetric, localized thickening of the upper interventricular septum and constitutes a marker of an early remodelling in patients with hypertension. This morphological trait has been extensively researched because of its prevalence in hypertension, yet its clinical and prognostic value for individual patients remains undetermined. One of the reasons is the lack of a reliable and reproducible metric to quantify the presence and the extent of BSH. This article proposes the use of the curvature of the left ventricular endocardium as a robust feature for BSH characterization, and as an objective criterion to quantify current subjective ‘visual assessment’ of the presence of sigmoidal septum. The proposed marker, called average septal curvature, is defined as the inverse of the radius adjacent to each point of the endocardial contour along the basal and mid inferoseptal segments of the left ventricle. Method: Robustness and reproducibility were assessed on a cohort of 220 patients, including 161 hypertensive patients (32 with BSH) and 59 healthy controls. Results: The results show that compared with the conventionally used wall thickness metrics, the new marker is more reproducible (relative standard deviation of errors of 7 vs. 13%, and 8 vs. 38% for intra-observer and inter-observer variability, respectively) and better correlates to the functional parameters related to BSH, with main difference (absolute rank correlation 0.417 vs. 0.341) in local deformation changes assessed by longitudinal strain. Conclusion: Average septal curvature is a more precisely defined and reproducible metric than thickness ratios, it can be fully automated, and better infers the functional remodelling related to hypertension. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/71561 http://dx.doi.org/10.1097/HJH.0000000000002813 http://hdl.handle.net/10230/71561 |
| url |
http://hdl.handle.net/10230/71561 http://dx.doi.org/10.1097/HJH.0000000000002813 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Journal of Hypertension. 2021 Jul;39(7):1421-8 info:eu-repo/grantAgreement/EC/H2020/764738 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wolters Kluwer |
| publisher.none.fl_str_mv |
Wolters Kluwer |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869417726512988160 |
| score |
15,812429 |