Cellular senescence is immunogenic and promotes anti-tumor immunity

Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific...

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Autores: Marin, Ines, Boix, Olga, Garcia Garijo, Andrea, Sirois, Isabelle, Caballe, Adrià, Zarzuela, Eduardo, Ruano, Irene, Stephan-Otto Attolini, Camille, Prats, Neus, López Domínguez, José A., Kovatchev, Marta, Garralda, Elena, Muñoz, Javier, Caron, Etinne, Abad, María, Gros, Alena, Pietrocola, Federico, Serrano Marugán, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192884
Acceso en línea:https://hdl.handle.net/2445/192884
Access Level:acceso abierto
Palabra clave:Cèl·lules canceroses
Immunitat cel·lular
Cancer cells
Cellular immunity
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spelling Cellular senescence is immunogenic and promotes anti-tumor immunityMarin, InesBoix, OlgaGarcia Garijo, AndreaSirois, IsabelleCaballe, AdriàZarzuela, EduardoRuano, IreneStephan-Otto Attolini, CamillePrats, NeusLópez Domínguez, José A.Kovatchev, MartaGarralda, ElenaMuñoz, JavierCaron, EtinneAbad, MaríaGros, AlenaPietrocola, FedericoSerrano Marugán, ManuelCèl·lules cancerosesImmunitat cel·lularCancer cellsCellular immunityCellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling, enhanced MHC class I machinery, and presentation of senescence-specific self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong anti-tumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses.American Association for Cancer Research2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion22 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/192884Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1158/2159-8290.CD-22-0523Cancer Discovery, 2023, vol. 13, num. 2, p. 410-431https://doi.org/10.1158/2159-8290.CD-22-0523cc by-nc-nd (c) Marin, Ines et al., 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1928842026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cellular senescence is immunogenic and promotes anti-tumor immunity
title Cellular senescence is immunogenic and promotes anti-tumor immunity
spellingShingle Cellular senescence is immunogenic and promotes anti-tumor immunity
Marin, Ines
Cèl·lules canceroses
Immunitat cel·lular
Cancer cells
Cellular immunity
title_short Cellular senescence is immunogenic and promotes anti-tumor immunity
title_full Cellular senescence is immunogenic and promotes anti-tumor immunity
title_fullStr Cellular senescence is immunogenic and promotes anti-tumor immunity
title_full_unstemmed Cellular senescence is immunogenic and promotes anti-tumor immunity
title_sort Cellular senescence is immunogenic and promotes anti-tumor immunity
dc.creator.none.fl_str_mv Marin, Ines
Boix, Olga
Garcia Garijo, Andrea
Sirois, Isabelle
Caballe, Adrià
Zarzuela, Eduardo
Ruano, Irene
Stephan-Otto Attolini, Camille
Prats, Neus
López Domínguez, José A.
Kovatchev, Marta
Garralda, Elena
Muñoz, Javier
Caron, Etinne
Abad, María
Gros, Alena
Pietrocola, Federico
Serrano Marugán, Manuel
author Marin, Ines
author_facet Marin, Ines
Boix, Olga
Garcia Garijo, Andrea
Sirois, Isabelle
Caballe, Adrià
Zarzuela, Eduardo
Ruano, Irene
Stephan-Otto Attolini, Camille
Prats, Neus
López Domínguez, José A.
Kovatchev, Marta
Garralda, Elena
Muñoz, Javier
Caron, Etinne
Abad, María
Gros, Alena
Pietrocola, Federico
Serrano Marugán, Manuel
author_role author
author2 Boix, Olga
Garcia Garijo, Andrea
Sirois, Isabelle
Caballe, Adrià
Zarzuela, Eduardo
Ruano, Irene
Stephan-Otto Attolini, Camille
Prats, Neus
López Domínguez, José A.
Kovatchev, Marta
Garralda, Elena
Muñoz, Javier
Caron, Etinne
Abad, María
Gros, Alena
Pietrocola, Federico
Serrano Marugán, Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules canceroses
Immunitat cel·lular
Cancer cells
Cellular immunity
topic Cèl·lules canceroses
Immunitat cel·lular
Cancer cells
Cellular immunity
description Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling, enhanced MHC class I machinery, and presentation of senescence-specific self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong anti-tumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192884
url https://hdl.handle.net/2445/192884
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1158/2159-8290.CD-22-0523
Cancer Discovery, 2023, vol. 13, num. 2, p. 410-431
https://doi.org/10.1158/2159-8290.CD-22-0523
dc.rights.none.fl_str_mv cc by-nc-nd (c) Marin, Ines et al., 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Marin, Ines et al., 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for Cancer Research
publisher.none.fl_str_mv American Association for Cancer Research
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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