In vitro study of synergy of ampicillin with ceftriaxone against Listeria monocytogenes
[EN] Objectives: To evaluate if the in vitro activity of ampicillin increases when combined with ceftriaxone.-- Material and methods: The activity of ampicillin and ceftriaxone was evaluated against six Listeria monocytogenes invasive clinical isolates. Ampicillin and ceftriaxone MICs were determine...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/201972 |
| Acceso en línea: | http://hdl.handle.net/10261/201972 |
| Access Level: | acceso abierto |
| Palabra clave: | Ceftriaxone Ampicillin Synergy Listeria CNS Ceftriaxona Ampicilina Sinergia SNC |
| Sumario: | [EN] Objectives: To evaluate if the in vitro activity of ampicillin increases when combined with ceftriaxone.-- Material and methods: The activity of ampicillin and ceftriaxone was evaluated against six Listeria monocytogenes invasive clinical isolates. Ampicillin and ceftriaxone MICs were determined by the broth microdilution method. Synergy was evaluated by checkerboard and time-kill curves methods.-- Results: All six L. monocytogenes strains were susceptible to ampicillin (MICs 0.25-0.5 mg/L). A bacteriostatic synergy was demonstrated by the FIC index of 0.5 and a 2.5 log10 CFU reduction on the six strains studied for MIC ampicillin plus 16 mg/L ceftriaxone concentrations.-- Conclusions: The association of ceftriaxone with ampicillin increases the in vitro activity of ampicillin, and therefore could be a valuable option in the treatment of invasive infection by L. monocytogenes. |
|---|