Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses

African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vacci...

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Autores: Barasona García-Arévalo, José Ángel, Cadenas Fernández, Estefanía, Kosowska, Aleksandra, Barroso Arévalo, Sandra, Rivera Arroyo, Belén, Sánchez, Rocío, Porras, Néstor, Gallardo, Carmina, Sánchez-Vizcaíno Rodríguez, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/100500
Acceso en línea:https://hdl.handle.net/20.500.14352/100500
Access Level:acceso abierto
Palabra clave:61
African swine fever
Control disease
Infectious disease
Safety studies
Vaccine
Virus
Wild boar
Ciencias
31 Ciencias Agrarias
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repository_id_str
spelling Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated DosesBarasona García-Arévalo, José ÁngelCadenas Fernández, EstefaníaKosowska, AleksandraBarroso Arévalo, SandraRivera Arroyo, BelénSánchez, RocíoPorras, NéstorGallardo, CarminaSánchez-Vizcaíno Rodríguez, José Manuel61African swine feverControl diseaseInfectious diseaseSafety studiesVaccineVirusWild boarCiencias31 Ciencias AgrariasAfrican swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed.Frontiers Media S.A.Universidad Complutense de Madrid20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/100500reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 862874open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1005002026-06-02T12:44:21Z
dc.title.none.fl_str_mv Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
spellingShingle Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
Barasona García-Arévalo, José Ángel
61
African swine fever
Control disease
Infectious disease
Safety studies
Vaccine
Virus
Wild boar
Ciencias
31 Ciencias Agrarias
title_short Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_full Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_fullStr Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_full_unstemmed Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_sort Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
dc.creator.none.fl_str_mv Barasona García-Arévalo, José Ángel
Cadenas Fernández, Estefanía
Kosowska, Aleksandra
Barroso Arévalo, Sandra
Rivera Arroyo, Belén
Sánchez, Rocío
Porras, Néstor
Gallardo, Carmina
Sánchez-Vizcaíno Rodríguez, José Manuel
author Barasona García-Arévalo, José Ángel
author_facet Barasona García-Arévalo, José Ángel
Cadenas Fernández, Estefanía
Kosowska, Aleksandra
Barroso Arévalo, Sandra
Rivera Arroyo, Belén
Sánchez, Rocío
Porras, Néstor
Gallardo, Carmina
Sánchez-Vizcaíno Rodríguez, José Manuel
author_role author
author2 Cadenas Fernández, Estefanía
Kosowska, Aleksandra
Barroso Arévalo, Sandra
Rivera Arroyo, Belén
Sánchez, Rocío
Porras, Néstor
Gallardo, Carmina
Sánchez-Vizcaíno Rodríguez, José Manuel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 61
African swine fever
Control disease
Infectious disease
Safety studies
Vaccine
Virus
Wild boar
Ciencias
31 Ciencias Agrarias
topic 61
African swine fever
Control disease
Infectious disease
Safety studies
Vaccine
Virus
Wild boar
Ciencias
31 Ciencias Agrarias
description African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/100500
url https://hdl.handle.net/20.500.14352/100500
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 862874
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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