Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia
Background/Objectives: Preeclampsia is associated with long-term cardiovascular and metabolic risks. This study aimed to evaluate metabolic and cardiovascular biochemical profiles in women with a history of preeclampsia and angiogenic imbalance during pregnancy. Methods: We conducted a cross-section...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:uabarcelona_::0f94e294786ea907bee89e5983087f55 |
| Acceso en línea: | https://ddd.uab.cat/record/327674 https://dx.doi.org/urn:doi:10.3390/jcm14238389 |
| Access Level: | acceso abierto |
| Palabra clave: | Preeclampsia sFlt-1 PlGF Cardiovascular risk Endothelial dysfunction Metabolic profile Biomarkers |
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Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After PreeclampsiaImpact of Angiogenic Imbalance During PregnancyCosta, NoahPlatero, JuditGarcía Manau, PabloSánchez García, Olga|||0000-0002-5279-440XJordi, MarionaGarcía Ruiz, Zoraida|||0009-0009-4631-763XGarrido-Giménez, Carmen|||0000-0003-2180-1715Ullmo, Johana|||0000-0002-9313-917XNan, Madalina Nicoleta|||0009-0001-2794-447XMora Brugués, Josefina|||0000-0001-6777-5132García Osuna, Álvaro|||0000-0002-6682-0226Choliz, MartaCruz-Lemini, Monica|||0000-0002-6807-3578Llurba, Elisa|||0000-0003-4048-6407Pellicer, ClaudiaMedina Mallen, Maria del Carmen|||0000-0002-1219-5947PreeclampsiasFlt-1PlGFCardiovascular riskEndothelial dysfunctionMetabolic profileBiomarkersBackground/Objectives: Preeclampsia is associated with long-term cardiovascular and metabolic risks. This study aimed to evaluate metabolic and cardiovascular biochemical profiles in women with a history of preeclampsia and angiogenic imbalance during pregnancy. Methods: We conducted a cross-sectional study at Hospital de la Santa Creu i Sant Pau between August 2023 and July 2025. Participants had been prospectively enrolled during pregnancy (2018-2022) and were re-evaluated 3 to 6 years later. Blood and urine samples were collected after a 12-h fast to assess hematological, metabolic, and cardiovascular markers. Angiogenic profiles were determined using sFlt-1/PlGF ratios obtained during pregnancy. Multivariable linear regression models were used to assess associations with a history of PE and angiogenic imbalance, adjusting for relevant confounders. Results: 363 participants were included. 113 (31.1%) had a history of preeclampsia. Women with previous preeclampsia showed slightly higher high-sensitivity troponin T concentrations [4.0 (3.0-6.0) ng/L vs. 3.2 (3.0-5.0) ng/L, p = 0.03]. Women with sFlt-1/PlGF ≥38 exhibited significantly higher urinary protein [0.09 (0.07-0.18) g/L vs. 0.08 (0.07-0.13) g/L, p = 0.01], potassium [4.25 (4.07-4.40) mmol/L vs. 4.19 (4.02-4.37) mmol/L, p = 0.048], and LDH concentrations [168 (150-189) U/L vs. 163 (149-177) U/L, p = 0.046], and lower leukocyte counts [6150 (5348-7055) vs. 6250 (5430-7450) U/mL, p = 0.03]. Conclusions: Women with angiogenic imbalance during pregnancy display subtle alterations in renal and endothelial function markers years after delivery, whereas those with preeclampsia show slightly higher troponin concentrations. These findings, though clinically irrelevant, suggest that pregnancy-related vascular dysfunction may have different long-term manifestations depending on whether the maternal cardiovascular system was sufficiently compromised to develop overt preeclampsia.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/327674https://dx.doi.org/urn:doi:10.3390/jcm14238389reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00462Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD21/0012/0001Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PT13/0002/0028Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD24/0013/0001open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::0f94e294786ea907bee89e5983087f552026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia Impact of Angiogenic Imbalance During Pregnancy |
| title |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia |
| spellingShingle |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia Costa, Noah Preeclampsia sFlt-1 PlGF Cardiovascular risk Endothelial dysfunction Metabolic profile Biomarkers |
| title_short |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia |
| title_full |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia |
| title_fullStr |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia |
| title_full_unstemmed |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia |
| title_sort |
Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia |
| dc.creator.none.fl_str_mv |
Costa, Noah Platero, Judit García Manau, Pablo Sánchez García, Olga|||0000-0002-5279-440X Jordi, Mariona García Ruiz, Zoraida|||0009-0009-4631-763X Garrido-Giménez, Carmen|||0000-0003-2180-1715 Ullmo, Johana|||0000-0002-9313-917X Nan, Madalina Nicoleta|||0009-0001-2794-447X Mora Brugués, Josefina|||0000-0001-6777-5132 García Osuna, Álvaro|||0000-0002-6682-0226 Choliz, Marta Cruz-Lemini, Monica|||0000-0002-6807-3578 Llurba, Elisa|||0000-0003-4048-6407 Pellicer, Claudia Medina Mallen, Maria del Carmen|||0000-0002-1219-5947 |
| author |
Costa, Noah |
| author_facet |
Costa, Noah Platero, Judit García Manau, Pablo Sánchez García, Olga|||0000-0002-5279-440X Jordi, Mariona García Ruiz, Zoraida|||0009-0009-4631-763X Garrido-Giménez, Carmen|||0000-0003-2180-1715 Ullmo, Johana|||0000-0002-9313-917X Nan, Madalina Nicoleta|||0009-0001-2794-447X Mora Brugués, Josefina|||0000-0001-6777-5132 García Osuna, Álvaro|||0000-0002-6682-0226 Choliz, Marta Cruz-Lemini, Monica|||0000-0002-6807-3578 Llurba, Elisa|||0000-0003-4048-6407 Pellicer, Claudia Medina Mallen, Maria del Carmen|||0000-0002-1219-5947 |
| author_role |
author |
| author2 |
Platero, Judit García Manau, Pablo Sánchez García, Olga|||0000-0002-5279-440X Jordi, Mariona García Ruiz, Zoraida|||0009-0009-4631-763X Garrido-Giménez, Carmen|||0000-0003-2180-1715 Ullmo, Johana|||0000-0002-9313-917X Nan, Madalina Nicoleta|||0009-0001-2794-447X Mora Brugués, Josefina|||0000-0001-6777-5132 García Osuna, Álvaro|||0000-0002-6682-0226 Choliz, Marta Cruz-Lemini, Monica|||0000-0002-6807-3578 Llurba, Elisa|||0000-0003-4048-6407 Pellicer, Claudia Medina Mallen, Maria del Carmen|||0000-0002-1219-5947 |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
Preeclampsia sFlt-1 PlGF Cardiovascular risk Endothelial dysfunction Metabolic profile Biomarkers |
| topic |
Preeclampsia sFlt-1 PlGF Cardiovascular risk Endothelial dysfunction Metabolic profile Biomarkers |
| description |
Background/Objectives: Preeclampsia is associated with long-term cardiovascular and metabolic risks. This study aimed to evaluate metabolic and cardiovascular biochemical profiles in women with a history of preeclampsia and angiogenic imbalance during pregnancy. Methods: We conducted a cross-sectional study at Hospital de la Santa Creu i Sant Pau between August 2023 and July 2025. Participants had been prospectively enrolled during pregnancy (2018-2022) and were re-evaluated 3 to 6 years later. Blood and urine samples were collected after a 12-h fast to assess hematological, metabolic, and cardiovascular markers. Angiogenic profiles were determined using sFlt-1/PlGF ratios obtained during pregnancy. Multivariable linear regression models were used to assess associations with a history of PE and angiogenic imbalance, adjusting for relevant confounders. Results: 363 participants were included. 113 (31.1%) had a history of preeclampsia. Women with previous preeclampsia showed slightly higher high-sensitivity troponin T concentrations [4.0 (3.0-6.0) ng/L vs. 3.2 (3.0-5.0) ng/L, p = 0.03]. Women with sFlt-1/PlGF ≥38 exhibited significantly higher urinary protein [0.09 (0.07-0.18) g/L vs. 0.08 (0.07-0.13) g/L, p = 0.01], potassium [4.25 (4.07-4.40) mmol/L vs. 4.19 (4.02-4.37) mmol/L, p = 0.048], and LDH concentrations [168 (150-189) U/L vs. 163 (149-177) U/L, p = 0.046], and lower leukocyte counts [6150 (5348-7055) vs. 6250 (5430-7450) U/mL, p = 0.03]. Conclusions: Women with angiogenic imbalance during pregnancy display subtle alterations in renal and endothelial function markers years after delivery, whereas those with preeclampsia show slightly higher troponin concentrations. These findings, though clinically irrelevant, suggest that pregnancy-related vascular dysfunction may have different long-term manifestations depending on whether the maternal cardiovascular system was sufficiently compromised to develop overt preeclampsia. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/327674 https://dx.doi.org/urn:doi:10.3390/jcm14238389 |
| url |
https://ddd.uab.cat/record/327674 https://dx.doi.org/urn:doi:10.3390/jcm14238389 |
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Inglés eng |
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Inglés |
| language |
eng |
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Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00462 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD21/0012/0001 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PT13/0002/0028 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD24/0013/0001 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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