Operationalization of a frailty index among older adults in the InCHIANTI study

The frailty index (FI) is a sensitive instrument to measure the degree of frailty in older adults, and is increasingly used in cohort studies on aging. To operationalize an FI among older adults in the "Invecchiare in Chianti" (InCHIANTI) study, and to validate its predictive capacity for...

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Autores: Hoogendijk, Emiel O.|||0000-0001-9660-5108, Stenholm, Sari, Ferrucci, Luigi, Bandinelli, Stefania|||0000-0002-6491-0850, Inzitari, Marco|||0000-0002-3796-0625, Cesari, Matteo|||0000-0002-0348-3664
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226232
Acceso en línea:https://ddd.uab.cat/record/226232
https://dx.doi.org/urn:doi:10.1007/s40520-020-01478-3
Access Level:acceso abierto
Palabra clave:Frail elderly
Frailty index
Deficit accumulation
Risk prediction
Geriatrics
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spelling Operationalization of a frailty index among older adults in the InCHIANTI studypredictive ability for all-cause and cardiovascular disease mortalityHoogendijk, Emiel O.|||0000-0001-9660-5108Stenholm, SariFerrucci, LuigiBandinelli, Stefania|||0000-0002-6491-0850Inzitari, Marco|||0000-0002-3796-0625Cesari, Matteo|||0000-0002-0348-3664Frail elderlyFrailty indexDeficit accumulationRisk predictionGeriatricsThe frailty index (FI) is a sensitive instrument to measure the degree of frailty in older adults, and is increasingly used in cohort studies on aging. To operationalize an FI among older adults in the "Invecchiare in Chianti" (InCHIANTI) study, and to validate its predictive capacity for mortality. Longitudinal data were used from 1129 InCHIANTI participants aged ≥ 65 years. A 42-item FI was operationalized following a standard procedure using baseline data (1998/2000). Associations of the FI with 3- and 6-year all-cause and cardiovascular disease (CVD) mortality were studied using Cox regression. Predictive accuracy was estimated by the area under the ROC curve (AUC), for a continuous FI score and for different cut-points. The median FI was 0.13 (IQR 0.08-0.21). Scores were higher in women, and at advanced age. The FI was associated with 3- and 6-year all-cause and CVD mortality (HR range per 0.01 FI increase = 1.03-1.07, all p < 0.001). The continuous FI score predicted the mortality outcomes with moderate-to-good accuracy (AUC range 0.72-0.83). When applying FI cut-offs between 0.15 and 0.35, the accuracy of this FI for predicting mortality was moderate (AUC range 0.61-0.76). Overall, the predictive accuracy of the FI was higher in women than in men. The FI operationalized in the InCHIANTI study is a good instrument to grade the risk of all-cause mortality and CVD mortality. More measurement properties, such as the responsiveness of this FI when used as outcome measure, should be investigated in future research. The online version of this article (10.1007/s40520-020-01478-3) contains supplementary material, which is available to authorized users. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226232https://dx.doi.org/urn:doi:10.1007/s40520-020-01478-3reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2262322026-06-06T12:50:31Z
dc.title.none.fl_str_mv Operationalization of a frailty index among older adults in the InCHIANTI study
predictive ability for all-cause and cardiovascular disease mortality
title Operationalization of a frailty index among older adults in the InCHIANTI study
spellingShingle Operationalization of a frailty index among older adults in the InCHIANTI study
Hoogendijk, Emiel O.|||0000-0001-9660-5108
Frail elderly
Frailty index
Deficit accumulation
Risk prediction
Geriatrics
title_short Operationalization of a frailty index among older adults in the InCHIANTI study
title_full Operationalization of a frailty index among older adults in the InCHIANTI study
title_fullStr Operationalization of a frailty index among older adults in the InCHIANTI study
title_full_unstemmed Operationalization of a frailty index among older adults in the InCHIANTI study
title_sort Operationalization of a frailty index among older adults in the InCHIANTI study
dc.creator.none.fl_str_mv Hoogendijk, Emiel O.|||0000-0001-9660-5108
Stenholm, Sari
Ferrucci, Luigi
Bandinelli, Stefania|||0000-0002-6491-0850
Inzitari, Marco|||0000-0002-3796-0625
Cesari, Matteo|||0000-0002-0348-3664
author Hoogendijk, Emiel O.|||0000-0001-9660-5108
author_facet Hoogendijk, Emiel O.|||0000-0001-9660-5108
Stenholm, Sari
Ferrucci, Luigi
Bandinelli, Stefania|||0000-0002-6491-0850
Inzitari, Marco|||0000-0002-3796-0625
Cesari, Matteo|||0000-0002-0348-3664
author_role author
author2 Stenholm, Sari
Ferrucci, Luigi
Bandinelli, Stefania|||0000-0002-6491-0850
Inzitari, Marco|||0000-0002-3796-0625
Cesari, Matteo|||0000-0002-0348-3664
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Frail elderly
Frailty index
Deficit accumulation
Risk prediction
Geriatrics
topic Frail elderly
Frailty index
Deficit accumulation
Risk prediction
Geriatrics
description The frailty index (FI) is a sensitive instrument to measure the degree of frailty in older adults, and is increasingly used in cohort studies on aging. To operationalize an FI among older adults in the "Invecchiare in Chianti" (InCHIANTI) study, and to validate its predictive capacity for mortality. Longitudinal data were used from 1129 InCHIANTI participants aged ≥ 65 years. A 42-item FI was operationalized following a standard procedure using baseline data (1998/2000). Associations of the FI with 3- and 6-year all-cause and cardiovascular disease (CVD) mortality were studied using Cox regression. Predictive accuracy was estimated by the area under the ROC curve (AUC), for a continuous FI score and for different cut-points. The median FI was 0.13 (IQR 0.08-0.21). Scores were higher in women, and at advanced age. The FI was associated with 3- and 6-year all-cause and CVD mortality (HR range per 0.01 FI increase = 1.03-1.07, all p < 0.001). The continuous FI score predicted the mortality outcomes with moderate-to-good accuracy (AUC range 0.72-0.83). When applying FI cut-offs between 0.15 and 0.35, the accuracy of this FI for predicting mortality was moderate (AUC range 0.61-0.76). Overall, the predictive accuracy of the FI was higher in women than in men. The FI operationalized in the InCHIANTI study is a good instrument to grade the risk of all-cause mortality and CVD mortality. More measurement properties, such as the responsiveness of this FI when used as outcome measure, should be investigated in future research. The online version of this article (10.1007/s40520-020-01478-3) contains supplementary material, which is available to authorized users.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/226232
https://dx.doi.org/urn:doi:10.1007/s40520-020-01478-3
url https://ddd.uab.cat/record/226232
https://dx.doi.org/urn:doi:10.1007/s40520-020-01478-3
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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