Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation

BACKGROUND/AIMS: Peripheral arterial vasodilation may be the key factor in the sodium and water retention of cirrhosis. The mechanism responsible for this vasodilation remains to be fully elucidated. Adrenomedullin is a novel peptide, highly expressed in cardiovascular tissues, with potent and long-...

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Autores: Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e, Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6, Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71, Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596, Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593, Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b, Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058, Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd, Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188
Tipo de recurso: artículo
Fecha de publicación:1998
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/20164
Acceso en línea:https://hdl.handle.net/10171/20164
Access Level:acceso abierto
Palabra clave:Adrenomedullin
Cirrhosis
Peripheral vasodilation
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spelling Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulationFernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260ePrada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4bMoreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5dddCuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188AdrenomedullinCirrhosisPeripheral vasodilationBACKGROUND/AIMS: Peripheral arterial vasodilation may be the key factor in the sodium and water retention of cirrhosis. The mechanism responsible for this vasodilation remains to be fully elucidated. Adrenomedullin is a novel peptide, highly expressed in cardiovascular tissues, with potent and long-lasting vasodilating activity. METHODS: The possible implication of adrenomedullin in the hemodynamic changes of cirrhosis has been investigated. We measured the plasma concentration of adrenomedullin in 20 cirrhotic patients and 11 healthy subjects. In addition, systemic, portal and renal hemodynamics, hormonal factors and renal function parameters were evaluated in the same patients. RESULTS: Circulating adrenomedullin was significantly higher in the group of patients with cirrhosis (72.1; 46-100 vs 21.6; 11-34 fmol/dl, respectively; p<0.02) and was directly correlated with the Pugh score (r: 0.6; p: 0.01), inversely correlated with the creatinine clearance (r: -0.6; p<0.01) and tended to inversely correlate with systemic vascular resistance index (r: -0.46; p: 0.07). There were no portal-peripheral differences in adrenomedullin levels. Transjugular intrahepatic portosystemic shunt insertion did not induce changes in the peripheral concentration of adrenomedullin, but baseline values of this hormone predicted the degree of hyperdynamic circulation after TIPS. CONCLUSIONS: Circulating adrenomedullin is increased in cirrhosis. These levels increase with the severity of the disease, especially in patients with hepatorenal syndrome. This peptide may contribute to vasodilation of cirrhosis.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20112011-12-0919981998-01-0119981998-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/20164reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/201642026-06-21T12:47:57Z
dc.title.none.fl_str_mv Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
title Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
spellingShingle Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e
Adrenomedullin
Cirrhosis
Peripheral vasodilation
title_short Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
title_full Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
title_fullStr Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
title_full_unstemmed Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
title_sort Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
dc.creator.none.fl_str_mv Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e
Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593
Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b
Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058
Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd
Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188
author Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e
author_facet Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e
Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593
Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b
Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058
Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd
Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188
author_role author
author2 Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6
Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593
Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b
Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058
Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd
Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Adrenomedullin
Cirrhosis
Peripheral vasodilation
topic Adrenomedullin
Cirrhosis
Peripheral vasodilation
description BACKGROUND/AIMS: Peripheral arterial vasodilation may be the key factor in the sodium and water retention of cirrhosis. The mechanism responsible for this vasodilation remains to be fully elucidated. Adrenomedullin is a novel peptide, highly expressed in cardiovascular tissues, with potent and long-lasting vasodilating activity. METHODS: The possible implication of adrenomedullin in the hemodynamic changes of cirrhosis has been investigated. We measured the plasma concentration of adrenomedullin in 20 cirrhotic patients and 11 healthy subjects. In addition, systemic, portal and renal hemodynamics, hormonal factors and renal function parameters were evaluated in the same patients. RESULTS: Circulating adrenomedullin was significantly higher in the group of patients with cirrhosis (72.1; 46-100 vs 21.6; 11-34 fmol/dl, respectively; p<0.02) and was directly correlated with the Pugh score (r: 0.6; p: 0.01), inversely correlated with the creatinine clearance (r: -0.6; p<0.01) and tended to inversely correlate with systemic vascular resistance index (r: -0.46; p: 0.07). There were no portal-peripheral differences in adrenomedullin levels. Transjugular intrahepatic portosystemic shunt insertion did not induce changes in the peripheral concentration of adrenomedullin, but baseline values of this hormone predicted the degree of hyperdynamic circulation after TIPS. CONCLUSIONS: Circulating adrenomedullin is increased in cirrhosis. These levels increase with the severity of the disease, especially in patients with hepatorenal syndrome. This peptide may contribute to vasodilation of cirrhosis.
publishDate 1998
dc.date.none.fl_str_mv 1998
1998-01-01
1998
1998-01-01
2011
2011-12-09
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/20164
url https://hdl.handle.net/10171/20164
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
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