Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells

Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine m...

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Authors: Soto Cerrato, Vanessa, Manuel-Manresa, Pilar, Hernando, Elsa, Calabuig-Fariñas, Silvia, Martínez-Romero, Alicia, Fernández Dueñas, Víctor, Sahlholm, Kristoffer, Knöpfel, Thomas, García Valverde, María, Rodilla Martín, Ananda Marina, Jantus Lewintre, Eloisa, Farràs, Rosa, Ciruela Alférez, Francisco, Pérez Tomás, Ricardo E., Quesada, Roberto
Format: article
Status:Versión aceptada para publicación
Publication Date:2015
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/167300
Online Access:https://hdl.handle.net/2445/167300
Access Level:Open access
Keyword:Apoptosi
Fisiologia
Cèl·lules mare
Patologia
Apoptosis
Physiology
Stem cells
Pathology
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spelling Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cellsSoto Cerrato, VanessaManuel-Manresa, PilarHernando, ElsaCalabuig-Fariñas, SilviaMartínez-Romero, AliciaFernández Dueñas, VíctorSahlholm, KristofferKnöpfel, ThomasGarcía Valverde, MaríaRodilla Martín, Ananda MarinaJantus Lewintre, EloisaFarràs, RosaCiruela Alférez, FranciscoPérez Tomás, Ricardo E.Quesada, RobertoApoptosiFisiologiaCèl·lules marePatologiaApoptosisPhysiologyStem cellsPathologyFacilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.American Chemical Society2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/167300Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1021/jacs.5b09970Journal of the American Chemical Society, 2015, vol. 137, num. 50, p. 15892-15898https://doi.org/10.1021/jacs.5b09970(c) American Chemical Society , 2015info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1673002026-05-27T06:46:51Z
dc.title.none.fl_str_mv Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
title Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
spellingShingle Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
Soto Cerrato, Vanessa
Apoptosi
Fisiologia
Cèl·lules mare
Patologia
Apoptosis
Physiology
Stem cells
Pathology
title_short Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
title_full Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
title_fullStr Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
title_full_unstemmed Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
title_sort Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
dc.creator.none.fl_str_mv Soto Cerrato, Vanessa
Manuel-Manresa, Pilar
Hernando, Elsa
Calabuig-Fariñas, Silvia
Martínez-Romero, Alicia
Fernández Dueñas, Víctor
Sahlholm, Kristoffer
Knöpfel, Thomas
García Valverde, María
Rodilla Martín, Ananda Marina
Jantus Lewintre, Eloisa
Farràs, Rosa
Ciruela Alférez, Francisco
Pérez Tomás, Ricardo E.
Quesada, Roberto
author Soto Cerrato, Vanessa
author_facet Soto Cerrato, Vanessa
Manuel-Manresa, Pilar
Hernando, Elsa
Calabuig-Fariñas, Silvia
Martínez-Romero, Alicia
Fernández Dueñas, Víctor
Sahlholm, Kristoffer
Knöpfel, Thomas
García Valverde, María
Rodilla Martín, Ananda Marina
Jantus Lewintre, Eloisa
Farràs, Rosa
Ciruela Alférez, Francisco
Pérez Tomás, Ricardo E.
Quesada, Roberto
author_role author
author2 Manuel-Manresa, Pilar
Hernando, Elsa
Calabuig-Fariñas, Silvia
Martínez-Romero, Alicia
Fernández Dueñas, Víctor
Sahlholm, Kristoffer
Knöpfel, Thomas
García Valverde, María
Rodilla Martín, Ananda Marina
Jantus Lewintre, Eloisa
Farràs, Rosa
Ciruela Alférez, Francisco
Pérez Tomás, Ricardo E.
Quesada, Roberto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Apoptosi
Fisiologia
Cèl·lules mare
Patologia
Apoptosis
Physiology
Stem cells
Pathology
topic Apoptosi
Fisiologia
Cèl·lules mare
Patologia
Apoptosis
Physiology
Stem cells
Pathology
description Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/167300
url https://hdl.handle.net/2445/167300
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1021/jacs.5b09970
Journal of the American Chemical Society, 2015, vol. 137, num. 50, p. 15892-15898
https://doi.org/10.1021/jacs.5b09970
dc.rights.none.fl_str_mv (c) American Chemical Society , 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Chemical Society , 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417668210065408
score 15,301603

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