Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses

The Genus Alpharetrovirus contains viruses pathogenic mainly for chickens, forming the Avian Sarcoma and Leukosis Virus group (ASLV). Cells of most Galliform species, besides chickens, contain genetic elements (endogenous retroviruses, ERVs) that could recombine with other alpharetroviruses or expre...

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Autores: Fandiño, Sergio, Gómez-Lucía Duato, María Esperanza, Benítez Rico, Laura, Domenech Gómez, Ana María
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/103389
Acceso en línea:https://hdl.handle.net/20.500.14352/103389
Access Level:acceso abierto
Palabra clave:578.8
598.2
636.5
Galliformes
phylogenetics
Alpharetrovirus
Avian Leukosis Virus (ALV)
Endogenous viruses
Phylogenetics
ERVs
Aves
Microbiología (Biología)
3109.05 Microbiología
2401.20 Ornitología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/103389
network_acronym_str ES
network_name_str España
repository_id_str
spelling Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant ProvirusesFandiño, SergioGómez-Lucía Duato, María EsperanzaBenítez Rico, LauraDomenech Gómez, Ana María578.8598.2636.5GalliformesphylogeneticsAlpharetrovirusAvian Leukosis Virus (ALV)Endogenous virusesPhylogeneticsERVsAvesMicrobiología (Biología)3109.05 Microbiología2401.20 OrnitologíaThe Genus Alpharetrovirus contains viruses pathogenic mainly for chickens, forming the Avian Sarcoma and Leukosis Virus group (ASLV). Cells of most Galliform species, besides chickens, contain genetic elements (endogenous retroviruses, ERVs) that could recombine with other alpharetroviruses or express proteins, complementing defective ASLV, which may successfully replicate and cause disease. However, they are quite unknown, and only ALV-F, from ring-necked pheasants, has been partially published. Upon scrutiny of 53 genomes of different avian species, we found Alpharetrovirus-like sequences only in 12 different Galliformes, including six full-length (7.4–7.6 Kbp) and 27 partial sequences. Phylogenetic studies of the regions studied (LTR, gag, pol, and env) consistently resulted in five almost identical clades containing the same ERVs: Clade I (presently known ASLVs); Clade II (Callipepla spp. ERVs); Clade IIIa (Phasianus colchicus ERVs); Clade IIIb (Alectoris spp. ERVs); and Clade IV (Centrocercus spp. ERVs). The low pol identity scores suggested that each of these Clades may be considered a different species. ORF analysis revealed that putatively encoded proteins would be very similar in length and domains to those of other alpharetroviruses and thus potentially functional. This will undoubtedly contribute to better understanding the biology of defective viruses, especially in wild Galliformes, their evolution, and the danger they may represent for other wild species and the poultry industry.MDPIUniversidad Complutense de Madrid20232023-12-3120232023-12-31journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/103389reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1033892026-06-02T12:44:21Z
dc.title.none.fl_str_mv Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
title Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
spellingShingle Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
Fandiño, Sergio
578.8
598.2
636.5
Galliformes
phylogenetics
Alpharetrovirus
Avian Leukosis Virus (ALV)
Endogenous viruses
Phylogenetics
ERVs
Aves
Microbiología (Biología)
3109.05 Microbiología
2401.20 Ornitología
title_short Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
title_full Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
title_fullStr Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
title_full_unstemmed Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
title_sort Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
dc.creator.none.fl_str_mv Fandiño, Sergio
Gómez-Lucía Duato, María Esperanza
Benítez Rico, Laura
Domenech Gómez, Ana María
author Fandiño, Sergio
author_facet Fandiño, Sergio
Gómez-Lucía Duato, María Esperanza
Benítez Rico, Laura
Domenech Gómez, Ana María
author_role author
author2 Gómez-Lucía Duato, María Esperanza
Benítez Rico, Laura
Domenech Gómez, Ana María
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 578.8
598.2
636.5
Galliformes
phylogenetics

Alpharetrovirus
Avian Leukosis Virus (ALV)
Endogenous viruses
Phylogenetics
ERVs
Aves
Microbiología (Biología)
3109.05 Microbiología
2401.20 Ornitología
topic 578.8
598.2
636.5
Galliformes
phylogenetics
Alpharetrovirus
Avian Leukosis Virus (ALV)
Endogenous viruses
Phylogenetics
ERVs
Aves
Microbiología (Biología)
3109.05 Microbiología
2401.20 Ornitología
description The Genus Alpharetrovirus contains viruses pathogenic mainly for chickens, forming the Avian Sarcoma and Leukosis Virus group (ASLV). Cells of most Galliform species, besides chickens, contain genetic elements (endogenous retroviruses, ERVs) that could recombine with other alpharetroviruses or express proteins, complementing defective ASLV, which may successfully replicate and cause disease. However, they are quite unknown, and only ALV-F, from ring-necked pheasants, has been partially published. Upon scrutiny of 53 genomes of different avian species, we found Alpharetrovirus-like sequences only in 12 different Galliformes, including six full-length (7.4–7.6 Kbp) and 27 partial sequences. Phylogenetic studies of the regions studied (LTR, gag, pol, and env) consistently resulted in five almost identical clades containing the same ERVs: Clade I (presently known ASLVs); Clade II (Callipepla spp. ERVs); Clade IIIa (Phasianus colchicus ERVs); Clade IIIb (Alectoris spp. ERVs); and Clade IV (Centrocercus spp. ERVs). The low pol identity scores suggested that each of these Clades may be considered a different species. ORF analysis revealed that putatively encoded proteins would be very similar in length and domains to those of other alpharetroviruses and thus potentially functional. This will undoubtedly contribute to better understanding the biology of defective viruses, especially in wild Galliformes, their evolution, and the danger they may represent for other wild species and the poultry industry.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-12-31
2023
2023-12-31
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/103389
url https://hdl.handle.net/20.500.14352/103389
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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