Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort

Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence...

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Autores: Torres Cortada, Gerard, Gracia Lavedan, Esther, González, Jessica, Henríquez Beltrán, Mario, Targa, Adriano, Royo, Maria, Bermúdez López, Marcelino, Castro Boqué, Eva, Valdivielso Revilla, José Manuel, Pamplona Gras, Reinald, Mauricio Puente, Dídac, Lecube, Albert, Barbé Illa, Ferran, de Batlle, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/469646
Acceso en línea:https://doi.org/10.1038/s41598-025-33414-8
https://hdl.handle.net/10459.1/469646
Access Level:acceso abierto
Palabra clave:Advanced glycation end-products (AGEs)
Cardiovascular risk
Lung function decline
Skin autofluorescence (SAF)
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
title Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
spellingShingle Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
Torres Cortada, Gerard
Advanced glycation end-products (AGEs)
Cardiovascular risk
Lung function decline
Skin autofluorescence (SAF)
title_short Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
title_full Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
title_fullStr Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
title_full_unstemmed Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
title_sort Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
dc.creator.none.fl_str_mv Torres Cortada, Gerard
Gracia Lavedan, Esther
González, Jessica
Henríquez Beltrán, Mario
Targa, Adriano
Royo, Maria
Bermúdez López, Marcelino
Castro Boqué, Eva
Valdivielso Revilla, José Manuel
Pamplona Gras, Reinald
Mauricio Puente, Dídac
Lecube, Albert
Barbé Illa, Ferran
de Batlle, Jordi
author Torres Cortada, Gerard
author_facet Torres Cortada, Gerard
Gracia Lavedan, Esther
González, Jessica
Henríquez Beltrán, Mario
Targa, Adriano
Royo, Maria
Bermúdez López, Marcelino
Castro Boqué, Eva
Valdivielso Revilla, José Manuel
Pamplona Gras, Reinald
Mauricio Puente, Dídac
Lecube, Albert
Barbé Illa, Ferran
de Batlle, Jordi
author_role author
author2 Gracia Lavedan, Esther
González, Jessica
Henríquez Beltrán, Mario
Targa, Adriano
Royo, Maria
Bermúdez López, Marcelino
Castro Boqué, Eva
Valdivielso Revilla, José Manuel
Pamplona Gras, Reinald
Mauricio Puente, Dídac
Lecube, Albert
Barbé Illa, Ferran
de Batlle, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Advanced glycation end-products (AGEs)
Cardiovascular risk
Lung function decline
Skin autofluorescence (SAF)
topic Advanced glycation end-products (AGEs)
Cardiovascular risk
Lung function decline
Skin autofluorescence (SAF)
description Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45-70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines in FEV, FVC, and FEV/FVC were analysed using adjusted models and generalized additive models, stratified by smoking status. Among 658 participants (median age 56 years, 48% female), median baseline SAF was 1.90 AU [1.60; 2.20]. Baseline lung function was preserved, with median FEV, FVC and FEV/FVC of 2795 mL [2270; 3,341], 3,525 mL [2870; 4300], and 78.6% [74.4; 82.8]. Annual declines were -  81.9 mL [- 120.6; - 43.3] for FEV, - 99.6 mL [- 159.3; - 37.9] for FVC, and - 0.04% [- 0.85; 0.70] for FEV/FVC. No significant associations were found between SAF and spirometry changes. Results were consistent across smoking subgroups. Baseline skin AGE levels did not predict pulmonary function decline over four years in middle-aged adults with cardiovascular risk factors. While SAF reflects cumulative AGE exposure, it has limited prognostic value for lung function in this population.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1038/s41598-025-33414-8
https://hdl.handle.net/10459.1/469646
url https://doi.org/10.1038/s41598-025-33414-8
https://hdl.handle.net/10459.1/469646
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-152233OB-I00
Reproducció del document publicat a https://doi.org/10.1038/s41598-025-33414-8
Scientific Reports, 2026, vol. 16, núm. 3428
dc.rights.none.fl_str_mv cc-by-nc-nd, (c) Gerard Torres Cortada et al., 2026
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv cc-by-nc-nd, (c) Gerard Torres Cortada et al., 2026
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohortTorres Cortada, GerardGracia Lavedan, EstherGonzález, JessicaHenríquez Beltrán, MarioTarga, AdrianoRoyo, MariaBermúdez López, MarcelinoCastro Boqué, EvaValdivielso Revilla, José ManuelPamplona Gras, ReinaldMauricio Puente, DídacLecube, AlbertBarbé Illa, Ferrande Batlle, JordiAdvanced glycation end-products (AGEs)Cardiovascular riskLung function declineSkin autofluorescence (SAF)Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45-70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines in FEV, FVC, and FEV/FVC were analysed using adjusted models and generalized additive models, stratified by smoking status. Among 658 participants (median age 56 years, 48% female), median baseline SAF was 1.90 AU [1.60; 2.20]. Baseline lung function was preserved, with median FEV, FVC and FEV/FVC of 2795 mL [2270; 3,341], 3,525 mL [2870; 4300], and 78.6% [74.4; 82.8]. Annual declines were -  81.9 mL [- 120.6; - 43.3] for FEV, - 99.6 mL [- 159.3; - 37.9] for FVC, and - 0.04% [- 0.85; 0.70] for FEV/FVC. No significant associations were found between SAF and spirometry changes. Results were consistent across smoking subgroups. Baseline skin AGE levels did not predict pulmonary function decline over four years in middle-aged adults with cardiovascular risk factors. While SAF reflects cumulative AGE exposure, it has limited prognostic value for lung function in this population.This work was supported by Instituto de Salud Carlos III (ISCIII) through the Project PI23/00237, and The Ministerio de Ciencia, Innovación y Universidades (MCIN) through the project IJC2018-037792-I, co-funded by the European Union. This research was also funded by the Spanish Ministry of Science, Innovation, and Universities (grant PID2023-152233OB-I00) and by the “European Regional Development Fund, A way of making Europe”. Further funded by Programa de donaciones “estar preparados” UNESPA (Madrid, Spain), and Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES) CB07/06/2008 an initiative of the Instituto de Salud Carlos III. With the support of the Generalitat of Catalonia (AGAUR—2021SGR00990) and with the support of the Diputació de Lleida. MHB is supported by Instituto de Salud Carlos III through a predoctoral fellowship (FI23/00253), co-funded by European Union; and from the 2023 “Grants for Research Staff in Training” (11th Edition, Modality E) of the IREP Program “amb la col·laboració de: Diputació de Lleida” and IRBLleida. ADST is supported by Instituto de Salud Carlos III (ISCIII) through the project CP23/00095 (Miguel Servet 2023), co-funded by the European Union. FB is supported by the ICREA Academia programme.Springer Nature2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1038/s41598-025-33414-8https://hdl.handle.net/10459.1/469646reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-152233OB-I00Reproducció del document publicat a https://doi.org/10.1038/s41598-025-33414-8Scientific Reports, 2026, vol. 16, núm. 3428cc-by-nc-nd, (c) Gerard Torres Cortada et al., 2026Attribution-NonCommercial-NoDerivatives 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:recercat.cat:10459.1/4696462026-05-29T05:05:01Z
score 15.811543

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