Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill

BACKGROUND: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. OBJECTIVE: To...

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Autores: Hildur, Kristin, Templado, Cristina, Zock, Jan-Paul, Giraldo, Jesús, Pozo-Rodríguez, Francisco, Frances, Alexandra, Monyarch, Gemma, Rodríguez-Trigo, Gema, Rodriguez-Rodriguez, Emma, Gómez, Federico Pablo, Antó i Boqué, Josep Maria, Barberà i Mir, Joan Albert, Fuster, Carme, Suoto, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/97240
Acceso en línea:https://hdl.handle.net/2445/97240
Access Level:acceso abierto
Palabra clave:Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Toxicologia genètica
Citogenètica
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Genetic toxicology
Cytogenetics
Cancer
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spelling Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil SpillHildur, KristinTemplado, CristinaZock, Jan-PaulGiraldo, JesúsPozo-Rodríguez, FranciscoFrances, AlexandraMonyarch, GemmaRodríguez-Trigo, GemaRodriguez-Rodriguez, EmmaGómez, Federico PabloAntó i Boqué, Josep MariaBarberà i Mir, Joan AlbertFuster, CarmeSuoto, AnaCatàstrofe del Prestige, Espanya, 2002Mutació (Biologia)Toxicologia genèticaCitogenèticaCàncerPrestige oil spill, Spain, 2002Mutation (Biology)Genetic toxicologyCytogeneticsCancerBACKGROUND: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. OBJECTIVE: To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. DESIGN: Follow-up study. SETTING: Fishermen cooperatives in coastal villages. PARTICIPANTS: Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. MEASUREMENTS: Chromosome damage in circulating lymphocytes. RESULTS: Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. LIMITATIONS: The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. CONCLUSION: The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals.Public Library of Science (PLoS)2016201620152016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/97240Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0132413PLoS One, 2015, vol. 10, num. 7, p. e0132413http://dx.doi.org/10.1371/journal.pone.0132413cc-by (c) Hildur, K. et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/972402026-05-29T05:05:01Z
dc.title.none.fl_str_mv Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
title Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
spellingShingle Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
Hildur, Kristin
Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Toxicologia genètica
Citogenètica
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Genetic toxicology
Cytogenetics
Cancer
title_short Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
title_full Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
title_fullStr Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
title_full_unstemmed Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
title_sort Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
dc.creator.none.fl_str_mv Hildur, Kristin
Templado, Cristina
Zock, Jan-Paul
Giraldo, Jesús
Pozo-Rodríguez, Francisco
Frances, Alexandra
Monyarch, Gemma
Rodríguez-Trigo, Gema
Rodriguez-Rodriguez, Emma
Gómez, Federico Pablo
Antó i Boqué, Josep Maria
Barberà i Mir, Joan Albert
Fuster, Carme
Suoto, Ana
author Hildur, Kristin
author_facet Hildur, Kristin
Templado, Cristina
Zock, Jan-Paul
Giraldo, Jesús
Pozo-Rodríguez, Francisco
Frances, Alexandra
Monyarch, Gemma
Rodríguez-Trigo, Gema
Rodriguez-Rodriguez, Emma
Gómez, Federico Pablo
Antó i Boqué, Josep Maria
Barberà i Mir, Joan Albert
Fuster, Carme
Suoto, Ana
author_role author
author2 Templado, Cristina
Zock, Jan-Paul
Giraldo, Jesús
Pozo-Rodríguez, Francisco
Frances, Alexandra
Monyarch, Gemma
Rodríguez-Trigo, Gema
Rodriguez-Rodriguez, Emma
Gómez, Federico Pablo
Antó i Boqué, Josep Maria
Barberà i Mir, Joan Albert
Fuster, Carme
Suoto, Ana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Toxicologia genètica
Citogenètica
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Genetic toxicology
Cytogenetics
Cancer
topic Catàstrofe del Prestige, Espanya, 2002
Mutació (Biologia)
Toxicologia genètica
Citogenètica
Càncer
Prestige oil spill, Spain, 2002
Mutation (Biology)
Genetic toxicology
Cytogenetics
Cancer
description BACKGROUND: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. OBJECTIVE: To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. DESIGN: Follow-up study. SETTING: Fishermen cooperatives in coastal villages. PARTICIPANTS: Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. MEASUREMENTS: Chromosome damage in circulating lymphocytes. RESULTS: Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. LIMITATIONS: The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. CONCLUSION: The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/97240
url https://hdl.handle.net/2445/97240
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0132413
PLoS One, 2015, vol. 10, num. 7, p. e0132413
http://dx.doi.org/10.1371/journal.pone.0132413
dc.rights.none.fl_str_mv cc-by (c) Hildur, K. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Hildur, K. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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