Synthesis of functionalized β-amino α,β-unsaturated esters and nitriles by nucleophilic vinylic substitution
The nucleophilic vinylic substitution of halogen by primary and secondary amines on methyl (E)- and (Z)-3-bromo-4,4-dimethoxy-2-butenoates (1) and the corresponding nitriles (2) leads to methyl 3-amino-4,4-dimethoxy-2-butenoates and the corresponding nitriles, respectively, in good yields. The stere...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1988 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/243934 |
| Acceso en línea: | http://hdl.handle.net/10261/243934 |
| Access Level: | acceso abierto |
| Sumario: | The nucleophilic vinylic substitution of halogen by primary and secondary amines on methyl (E)- and (Z)-3-bromo-4,4-dimethoxy-2-butenoates (1) and the corresponding nitriles (2) leads to methyl 3-amino-4,4-dimethoxy-2-butenoates and the corresponding nitriles, respectively, in good yields. The stereochemistry of the reactions has also been studied. |
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