Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies

Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD), psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by acting mainly on 5-HT2A receptors. Recently, the interest of psychedelics as pharmacological treatment for psychiatric disorders ha...

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Detalhes bibliográficos
Autores: Calleja Conde, Javier, Morales García, José Ángel, Echeverry Alzate, Víctor, Buhler, Kora Mareen Katharina, Giné Domínguez, Elena, López Moreno, José Antonio
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/71979
Acesso em linha:https://hdl.handle.net/20.500.14352/71979
Access Level:acceso abierto
Palavra-chave:Alcohol
Ayahuasca
Classic psychedelics
LSD
Mescaline
Psilocybin
Psicología (Psicología)
61 Psicología
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spelling Classic psychedelics and alcohol use disorders: A systematic review of human and animal studiesCalleja Conde, JavierMorales García, José ÁngelEcheverry Alzate, VíctorBuhler, Kora Mareen KatharinaGiné Domínguez, ElenaLópez Moreno, José AntonioAlcoholAyahuascaClassic psychedelicsLSDMescalinePsilocybinPsicología (Psicología)61 PsicologíaClassic psychedelics refer to substances such as lysergic acid diethylamide (LSD), psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by acting mainly on 5-HT2A receptors. Recently, the interest of psychedelics as pharmacological treatment for psychiatric disorders has increased significantly, including their use on problematic use of alcohol. This systematic review is aimed to analyse the last two decades of studies examining the relationship between classic psychedelics and alcohol consumption. We searched PubMed and PsycInfo for human and preclinical studies published between January 2000 to December 2021. The search identified 639 publications. After selection, 27 studies were included. Human studies (n = 20) generally show promising data and seem to indicate that classic psychedelics could help reduce alcohol consumption. Nevertheless, some of these studies present methodological concerns such as low number of participants, lack of control group or difficulty in determining the effect of classic psychedelics in isolation. On the other hand, preclinical studies (n = 7) investigating the effect of these compounds on voluntary alcohol consumption are scarce and show some conflicting data. Among these compounds, psilocybin seems to show the most consistent data indicating that this compound could be a potential candidate to treat alcohol use disorders. In the absence of understanding the biological and/or psychological mechanisms, more studies including methodological quality parameters are needed to finally determine the effects of classic psychedelics on alcohol consumption.WileyUniversidad Complutense de Madrid20222022-08-3120222022-08-31journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/71979reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 3.0 Españahttps://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/719792026-06-02T12:44:21Z
dc.title.none.fl_str_mv Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
title Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
spellingShingle Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
Calleja Conde, Javier
Alcohol
Ayahuasca
Classic psychedelics
LSD
Mescaline
Psilocybin
Psicología (Psicología)
61 Psicología
title_short Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
title_full Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
title_fullStr Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
title_full_unstemmed Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
title_sort Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
dc.creator.none.fl_str_mv Calleja Conde, Javier
Morales García, José Ángel
Echeverry Alzate, Víctor
Buhler, Kora Mareen Katharina
Giné Domínguez, Elena
López Moreno, José Antonio
author Calleja Conde, Javier
author_facet Calleja Conde, Javier
Morales García, José Ángel
Echeverry Alzate, Víctor
Buhler, Kora Mareen Katharina
Giné Domínguez, Elena
López Moreno, José Antonio
author_role author
author2 Morales García, José Ángel
Echeverry Alzate, Víctor
Buhler, Kora Mareen Katharina
Giné Domínguez, Elena
López Moreno, José Antonio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Alcohol
Ayahuasca
Classic psychedelics
LSD
Mescaline
Psilocybin
Psicología (Psicología)
61 Psicología
topic Alcohol
Ayahuasca
Classic psychedelics
LSD
Mescaline
Psilocybin
Psicología (Psicología)
61 Psicología
description Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD), psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by acting mainly on 5-HT2A receptors. Recently, the interest of psychedelics as pharmacological treatment for psychiatric disorders has increased significantly, including their use on problematic use of alcohol. This systematic review is aimed to analyse the last two decades of studies examining the relationship between classic psychedelics and alcohol consumption. We searched PubMed and PsycInfo for human and preclinical studies published between January 2000 to December 2021. The search identified 639 publications. After selection, 27 studies were included. Human studies (n = 20) generally show promising data and seem to indicate that classic psychedelics could help reduce alcohol consumption. Nevertheless, some of these studies present methodological concerns such as low number of participants, lack of control group or difficulty in determining the effect of classic psychedelics in isolation. On the other hand, preclinical studies (n = 7) investigating the effect of these compounds on voluntary alcohol consumption are scarce and show some conflicting data. Among these compounds, psilocybin seems to show the most consistent data indicating that this compound could be a potential candidate to treat alcohol use disorders. In the absence of understanding the biological and/or psychological mechanisms, more studies including methodological quality parameters are needed to finally determine the effects of classic psychedelics on alcohol consumption.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-31
2022
2022-08-31
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/71979
url https://hdl.handle.net/20.500.14352/71979
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 3.0 España
https://creativecommons.org/licenses/by-nc/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 3.0 España
https://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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